The water-soluble fraction (<10 kD) of bee venom (Apis mellifera) produces inhibitory effect on apical transporters in renal proximal tubule cells

Kidney and Blood Pressure Research

Volumn 25, Issue 6, 2002, Pages 375-383

  Han, Ho Jae ^a   Yoon, Byeong Cheol ^a   Oh, Young Joon ^a   Park, Soo Hyun ^b   Lee, Jang Hern ^c   Mar, Woong Chon ^c  

^a Chonnam National University   (South Korea)

^b Chonbuk National University   (South Korea)

^c Seoul National University   (South Korea)

Author keywords

Apis mellifera; Arachidonic acid; Bee venom; Ca2+; Kidney; Oxidative stress; Transporter

Indexed keywords

ACETIC ACID ETHYL ESTER; ACETYLCYSTEINE; ALPHA METHYLGLUCOSIDE; ALPHA TOCOPHEROL; ANTIOXIDANT; ASCORBIC ACID; BEE VENOM; HEXANE; MEPACRINE; PHOSPHATE; PHOSPHOLIPASE A2 INHIBITOR; SODIUM ION; WATER;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL VIABILITY; CONTROLLED STUDY; HONEYBEE; KIDNEY CELL; KIDNEY PROXIMAL TUBULE; MALE; MOLECULAR WEIGHT; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SODIUM TRANSPORT; SOLUBILITY;

ANIMALS; ARACHIDONIC ACID; BEE VENOMS; BIOLOGICAL TRANSPORT; CALCIUM; CELL SURVIVAL; KIDNEY TUBULES, PROXIMAL; MALE; METHYLGLUCOSIDES; OXIDATIVE STRESS; PHOSPHATES; PHOSPHOLIPASES A; RABBITS; SIGNAL TRANSDUCTION; SODIUM; SOLUBILITY; TRITIUM;

EID: 0036994667     PISSN: 14204096     EISSN: None     Source Type: Journal    
DOI: 10.1159/000068696     Document Type: Article

References (37)

1. Chung SD, Alavi N, Livingston D, Hiller S, Taub M: Characterization of primary rabbit kidney cultures that express proximal tubule functions in a hormonally defined medium. J Cell Biol 1982;95:118-126.
2. Han HJ, Kang JW, Park KM, Lee JH, Yang IL: Functional characterization of primary culture cells grown in hormonally, serum-free medium and serum-supplemented medium. Korean J Vet Res 1996;36:551-563.
3. Habermann E: Bee venom and wasp venoms. Science 1972;177:314-322.
4. Lariviere WR, Melzack R: The bee venom test: A new tonic-pain test. Pain 1996;66:271-277.
5. Gauldie J, Hanson JM, Rumjannek FD, Shipolini RA, Veison CA: The peptide components of bee venom. Eur J Biochem 1976;61:369-376.
6. 2 from bee venom: Apparent activation by intervesicle exchange of phospholipids. Biochemistry 1997;36:3882-3893.
7. Schumacher MJ, Schmidt JO, Egen NB, Dillon KA: Biochemical variability of venoms from individual Europian and Africanized honeybees (Apis mellifera). J Allergy Clin Immunol 1992;90:59-65.
8. dos Reis MA, Costa RS, Coimbra TM, Dantas M, Gomes UA: Renal changes induced by envenomation with Africanized bee venom in female Wistar rats. Kidney Blood Prss Res 1997;20:271-277.
9. Han HJ, Lee JH, Park SH, Choi HJ, Yang IS, Mar WC, Kang SK, Lee HJ: Effect of bee venom and its melittin on apical transporters of renal proximal tubule cells. Kidney Blood Press Res 2000;23:393-399.
10. Vetter RS, Visscher PK, Camazine S: Mass envenomations by honey bees and wasps. West J Med 1999;170:223-227.
11. 2 and myoendothelial gap junctions in melittin-induced arterial relaxation. Eur J Pharmacol 2000;406:239-245.
12. Fletcher JE, Jiang MS: Possible mechanisms of action of cobra snake venom cardiotoxins and bee venom melittin. Toxicon 1993;31:669-695.
13. Klahr S: Oxygen radicals and renal diseases. Miner Electrolyte Metab 1997;23:140-143.
14. Abbate M, Remuzzi G: Acceleration of recovery in acute renal failure: from cellular mechanisms of tubular repair to innovative targeted therapies. Ren Fail 1996;18:377-388.
15. 1 cells: Mechanisms of injury. Am J Physiol 1993;265:F377-F384.
16. Babenko NA, Ruiz-Larrea MB, Martinez R, Martin C, Lacort M: Inhibition by estrogens of the oxidant-mediated mobilization of arachidonic acid in hepatocytes. J Physiol Biochem 1998;54:77-84.
17. Josephson RA, Silverman HS, Lakatta EG, Stern MD, Zweier JL: Study of the mechanisms of hydrogen peroxide and hydroxyl free radical-induced cellular injury and calcium overload in cardiac myocytes. J Biol Chem 1991;266:2354-2361.
18. Thannickal VJ, Fanburg BL: Reactive oxygen species in cell signaling. Am J Physiol Lung Cell Mol Physiol 2000;279:L1005-L1028.
19. + transport by angiotensin II in primary renal cells. Kidney Int 2000;57:2457-2467.
20. Park SH, Taub M, Han HJ: Regulation of phosphate uptake in primary cultured rabbit renal proximal tubule cells by glucocorticoids: Evidence for nongenomic as well as genomic mechanisms. Endocrinology 2001;142:710-712.
21. Bradford MM: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976;72:248-254.
22. Kolecki P: Delayed toxic reaction following massive bee envenomation. Ann Emerg Med 1999;33:114-116.
23. Ewan PW: Venom allergy. BMJ 1998;316:1365-1368.
24. 2. Toxicon 1990;28:647-656.
25. Mollay C, Kreil G, Berger H: Action of phospholipases on the cytoplasmic membrane of Escherichia coli: Stimulation by melittin. Biochim Biophys Acta 1976;426:317-324.
26. Hassid A, Levine L: Stimulation of phospholipase activity and prostaglandin biosynthesis by melittin in cell culture and in vivo. Res Commun Chem Path Pharm 1977;18;507-517.
27. Fletcher JE, Jiang MS: Possible mechanisms of action of cobra snake venom cardiotoxins and bee venom melittin. Toxicon 1993;31:669-695.
28. 2 and glutamate on inducing cell death and sustained arachidonic acid metabolic changes in primary cortical neuronal cultures. J Biol Chem 1996;271:32722-32728.
29. Mau SE, Vilhardt H: Cross talk between substance P and melittin-activated cellular signaling pathways in rat lactotroph-enriched cell cultures. J Neurochem 1997;69:762-672.
30. 2 dependent. J Appl Physiol 1999;87:792-800.
31. 2 dependence of diaphragm mitochondrial formation of reactive oxygen species. J Appl Physiol 2000;89:72-80.
32. Vento R, D'Alessandro N, Giuliano M, Lauricella M, Carabillo M, Tesoriere G: Induction of apoptosis by arachidonic acid in human retino-blastoma Y79 cells: Involvement of oxidative stress. Exp Eye Res 2000;70:503-517.
33. Jourd'Heuil D, Vaananen P, Meddings JB: Lipid peroxidation of the brush-border membrane: Membrane physical properties and glucose transport. Am J Physiol 1993;264:G1009-G1015.
34. 2 and arachidonic acid. Biochem J 1998;336:659-666.
35. Okamoto T, Isoda H, Kubota N, Takahata K, Takahashi T, Kishi T, Nakamura TY, Muromachi Y, Matsui Y, Goshima K: Melittin cardiotoxicity in cultured mouse cardiac myocytes and its correlation with calcium overload. Toxicol Appl Pharmacol 1995;133:150-163.
36. Oe H, Kuzuya T, Hoshida S, Nishida M, Hori M, Kamada T, Tada M: Calcium overload and cardiac myocyte cell damage induced by arachidonate lipoxygenation. Am J Physiol 1994;267:H1396-H1402.
37. O'Neil BJ, McKeown TR, DeGracia DJ, Alousi SS, Rafols JA, White BC: Cell death, calcium mobilization, and immunostaining for phosphorylated eukaryotic initiation factor 2-alpha (eIF2alpha) in neuronally differentiated NB-104 cells: Arachidonate and radical-mediated injury mechanisms. Resuscitation 1999;41:71-83.