Successful management of drooling with botulinum toxin A in neurologically disabled children

Neuropediatrics

Volumn 33, Issue 6, 2002, Pages 327-330

  Ellies, M ^a,b   Rohrbach Volland, S ^a   Arglebe, C ^a   Wilken, B ^a   Laskawi, R ^a   Hanefeld, F ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

Author keywords

Botulinum Toxin A; Children; Drooling; Neurologic Diseases; Salivary Glands

Indexed keywords

ACID PHOSPHATASE; AMYLASE; BOTULINUM TOXIN A; IMMUNOGLOBULIN A; KALLIKREIN; SALIVA PROTEIN;

ADOLESCENT; ANALYTIC METHOD; ARTICLE; BIOCHEMISTRY; CLINICAL ARTICLE; CLINICAL EXAMINATION; CONTROLLED STUDY; DEGENERATIVE DISEASE; DISABILITY; DISEASE SEVERITY; DRUG EFFECT; ECHOGRAPHY; ENZYME ACTIVITY; FEMALE; HUMAN; HYPERSALIVATION; LOCAL ANESTHESIA; MALE; PAROTID GLAND; PRIORITY JOURNAL; QUALITY OF LIFE; SALIVA LEVEL; SALIVATION; SCHOOL CHILD; SIDE EFFECT; SUBMANDIBULAR GLAND; SYMPTOM;

ADOLESCENT; BOTULINUM TOXIN TYPE A; CHILD; FEMALE; HUMANS; INJECTIONS, SUBCUTANEOUS; MALE; NEURODEGENERATIVE DISEASES; PAROTID GLAND; SALIVATION; SIALORRHEA; SUBMANDIBULAR GLAND; TREATMENT OUTCOME;

EID: 0036990918     PISSN: 0174304X     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2002-37084     Document Type: Article

References (18)

1. Arnold HG, Gross CW. Transtympanic neurectomy: a solution to drooling problems. Dev Med Child Neurol 1977; 19: 509-513
2. Beuche W, Arglebe C, Laskawi R. Quantitative reduction of saliva production in two ALS patients with intraglandular injections of botulinum toxin. Neurol Psychiatry Brain Res 2000; 8: 23-26
3. Bushara KO. Sialorrhea in amyotrophic lateral sclerosis: a hypothesis of a new treatment - botulinum toxin A injections of the parotid glands. Med Hypotheses 1997; 48: 337-339
4. Crysdale WS, Raveh E, McCann C, Roske L, Kotler A. Management of drooling in individuals with neurodisability: a surgical experience. Dev Med Child Neurol 2001; 43: 379-383
5. Ellies M, Laskawi R, Götz W, Arglebe C, Tormählen G. Immunohistochemical and morphometric investigations of the influence of botulinum toxin on the submandibular gland of the rat. Eur Arch Otorhinolaryngol 1999; 256: 148-152
6. Ellies M, Laskawi R, Rohrbach-Volland S, Arglebe C. Up-to-date report of botulinum toxin therapy in patients with drooling caused by different etiologies. J Oral Maxillofac Surg in press
7. Ellies M, Laskawi R, Rohrbach-Volland S, Arglebe C, Beuche W. Botulinum toxin to reduce saliva flow: selected indications for ultrasound-guided toxin application into salivary glands. Laryngoscope 2002; 112: 82-86
8. Ellies M, Laskawi R, Rohrbach-Volland S, Rödel R, Beuche W. Blocking of secretion in exocrine glands of the head and neck area with botulinum toxin A. Therapeutic option in the treatment of rare diseases. HNO 2001; 49: 807-813
9. Ellies M, Laskawi R, Schütz S, Rohrbach-Volland S. Immunohistochemical evidence of nNOS and changes after intraglandular application of botulinum toxin A in cephalic salivary glands of adult rats. Eur Arch Otorhinolaryngol 2001; 258: 317
10. Ellies M, Laskawi R, Tormählen G, Götz W. The effect of local injection of botulinum toxin A on the parotid gland of the rat. An immunohisotochemical and morphometric study. J Oral Maxillofac Surg 2000; 58: 1251-1256
11. Giess R, Naumann M, Werner E, Riemann R, Beck M, Puls I, Reiners C, Toyka KV. Injections of botulinum toxin A into the salivary glands improve sialorrhoea in amyotrophic lateral sclerosis. J Neurol Neurosurg Psychiatry 2000; 69: 121-123
12. Jongerius PH, Rooteveel JJ, van den Hoogen F, Joosten F, van Hulst K, Gabreëls FJM. Botulinum toxin A: a new option for treatment of drooling in children with cerebral palsy. Presentation of a case series. Eur J Pediatr 2001; 160: 509-512
13. Laskawi R, Drobik C, Schönebeck C. Up-to-date report of botulinum toxin treatment in patients with gustatory sweating. Laryngoscope 1998; 108: 381-384
14. Mann AC. Localised autonomic failure due to botulinum toxin injection. J Neurol Neurosurg Psychiatry 1994; 57: 1320
15. Mullins WM, Gross CW, Moore Long-term follow-up of tympanic neurectomy for sialorrhea. Laryngoscope 1979; 89: 1219-1223
16. Pal PK, Calne DB, Calne S, Tsui JKC. Botulinum toxin A as treatment for drooling saliva in PD. Neurology 2000; 54: 244-247
17. Porta M, Gamba M, Bertacci G, Vaj P. Treatment of sialorrhoea with ultrasound guided botulinum toxin type A injections in patients with neurological disorders. J Neurol Neurosurg Psychiatry 2001; 70: 538-540
18. Suskind DL, Tilton A. Clinical study of botulinum A toxin in the treatment of sialorrhea in children with cerebral palsy. Laryngoscope 2002; 112: 73-81