Apolipoprotein E and angiotensin converting enzyme genes: Regional differences and extreme longevity in Europe

Archives of Gerontology and Geriatrics

Volumn 35, Issue SUPPL. 8, 2002, Pages 247-251

  Panza, F ^a   Solfrizzi, V ^a   D'Introno, A ^a   Capurso, C ^a   Basile, A M ^a   Colacicco, A M ^a   Sabba, M ^a   Noya, R ^a   Capurso, A ^a  

^a UNIVERSITY OF BARI   (Italy)

Author keywords

Angiotensin converting enzyme; Apolipoprotein E; Centenarians; Southern Italy

Indexed keywords

APOLIPOPROTEIN E; DIPEPTIDYL CARBOXYPEPTIDASE;

AGED; CONFERENCE PAPER; CONTROLLED STUDY; EUROPE; EVALUATION; FRANCE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENOTYPE; HIGH RISK POPULATION; HUMAN; ITALY; LONGEVITY; MAJOR CLINICAL STUDY; POPULATION GENETICS; PREVALENCE; PRIORITY JOURNAL;

EID: 0036989860     PISSN: 01674943     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-4943(02)00141-3     Document Type: Conference Paper

References (14)

1. Bladbjerg, E.M., Andersen-Ranberg, K., de Maat, M.P., Kristensen, S.R., Jeune, B., Gram, J. and Jespersen, J. (1999): Longevity is independent of common variations in genes associated with cardiovascular risk. Thromb. Haemos., 82, 1100-1105.
2. Blanchè, H., Cabanne, L., Sahbatou, M. and Thomas, G. (2001): A study of French centenarians: are ACE and APOE associated with longevity? C. R. Acad. Sci. III, 324, 129-135.
3. Cambien F., Poirier O., Lecerf L., Evans A., Cambou J.P., Arveiler D., Luc G., Bard J.M., Bara L., Ricard S., Tiret L., Amouyel P., Alhenc-Gelas F., Soubrier F. (1992): Deletion polymorphism in the gene for angiotensin-converting enzyme is a potent risk factor for myocardial infarction. Nature, 359, 641-644.
4. Davignon, J., Bouthillier, D., Nestruck, A.C. and Sing, C.F (1987): Apolipoprotein E polymorphism and atherosclerosis: insight from a study in octagenarians. Trans. Am. Clin. Climatol. Assoc., 99, 100-110.
5. Davignon, J., Gregg, R. E. and Sing, C.F. (1988): Apolipoprotein E polymorphism and atherosclerosis. Arteriosclerosis, 8, 1-21.
6. Frisoni, G.B., Louhija, J., Geroldi, C and Trabucchi, M. (2001): Longevity and the epsilon2 allele of apolipoprotein E: the Finnish Centenarian Study. J. Gerontol. A. Biol. Sci. Med., 56, M-75-M78.
7. Kehoe, P.G., Russ, C., Mcllory, S., Williams, H., Holmans, P., Holmes, C., Liolitsa, D., Vahidassr, D., Powell, J., McGleenon, B., Liddell, M., Plomin, R., Dynan, K., Williams, N., Neal, J., Cairns, N.J., Wilcock, G., Passmore, P., Lovestone, S., Williams, J. and Owen, M.J. (1999): Variation in DCP1, encoding ACE, is associated with susceptibility to Alzheimer disease. Nature Genet., 21, 71-72.
8. Kervinen, K., Savolainen, M.J., Salokannel, J., Hynninen, A., Heikkinnen, J., Ehnholm, C., Koistinen, M.J. and Kesaniemi, Y.A. (1994): Apolipoprotein E and B polymorphisms: longevity factors assessed in nonagenarians. Atherosclerosis, 105, 89-95.
9. Louhija, J., Miettinen, H.E., Kontula, K., Tikkanen, M.J., Miettinen, T.A. and Tilvis, R.S. (1994): Aging and genetic variation of plasma apolipoproteins. Relative loss of the apolipoprotein E4 phenotype in centenarians. Arterioscl. Thromb., 14, 1084-1089.
10. Panza, F., Solfrizzi, V., Torres, F., Mastroianni, F., Del Parigi, A., Colacicco, A.M., Basile, A.M., Capurso, C., Noya, R. and Capurso, A. (1999): Decreased frequency of apolipoprotein E epsilon4 allele from Northern to Southern Europe in Alzheimer's disease patients and centenarians. Neurosci. Lett., 277, 53-56.
11. Rigat, B., Hubert, C., Alhenc-Gelas, F., Cambien, F., Corvol, P. and Soubrier, F. (1990): An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. J. Clin. Invest., 86, 1343-1346.
12. Rigat, B., Hubert, C., Corvol, P. and Soubrier, F (1992): PCR detection of the insertion/deletion polymorphism of the human angiotensin converting enzyme gene (DCP1) (dipeptidyl carboxypeptidase 1). Nucleic Acids Res., 20, 1433.
13. Saunders, A.M., Strittmatter, W.J., Schmechel, D., St. George-Hyslop, P.H., Pericak-Vance, M.A., Joo, S.H., Rosi, B.L., Gusella, J.F., Crapper- MacLachlan, D.R., Alberts, M.J., Hulette, C., Crain, B., Goldgaber, D. and Roses, A.D. (1993): Association of apolipoprotein E allele ε4 with late-onset familial and sporadic Alzheimer's disease. Neurology, 43, 1467-1472.
14. Shachter, F., Faure-Delanef, L., Guenot, F., Rouger, H., Froguel, P., Lesueur-Ginot, L. and Cohen, D. (1994): Genetic associations with human longevity at the APOE and ACE loci. Nature Genet., 16, 29-32.