Analysis of association of the Col1a1 gene alleles with the risk of osteoporosis

Genetika

Volumn 38, Issue 12, 2002, Pages 1699-1703

  Moskalenko, M V ^a   Aseev, M V ^a   Zazerskaya, I E ^b   Kotova, S M ^c   Ivaschenko, T E ^a   Baranov, V S ^a  

^a D O OTT RESEARCH INSTITUTE OF OBSTETRICS   (Russian Federation)

^b ST PETERSBURG STATE UNIVERSITY   (Russian Federation)

^c PAVLOV FIRST SAINT PETERSBURG STATE MEDICAL UNIVERSITY   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

ESTRADIOL; COLLAGEN; COLLAGEN TYPE 1; COLLAGEN TYPE I, ALPHA 1 CHAIN;

ARTICLE; CHILD; COLLAL GENE; CONTROLLED STUDY; FRACTURE; GENE; GENE FREQUENCY; GENETIC ANALYSIS; GENETIC PREDISPOSITION; HEREDITY; HUMAN; IDIOPATHIC OSTEOPOROSIS; MAJOR CLINICAL STUDY; OSTEOPOROSIS; POLYMERASE CHAIN REACTION; POSTMENOPAUSE OSTEOPOROSIS; RISK FACTOR; SITE DIRECTED MUTAGENESIS; STATISTICAL ANALYSIS; ADOLESCENT; ADULT; ALLELE; CASE CONTROL STUDY; FEMALE; GENETIC POLYMORPHISM; GENETICS; MIDDLE AGED; RUSSIAN FEDERATION;

ADOLESCENT; ADULT; ALLELES; CASE-CONTROL STUDIES; COLLAGEN; COLLAGEN TYPE I; FEMALE; FRACTURES, BONE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MIDDLE AGED; OSTEOPOROSIS; POLYMORPHISM, GENETIC; RUSSIA;

EID: 0036981095     PISSN: 00166758     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Melton L., Atkinson E., O Fallon W. et al. Long-term fracture prediction by bone mineral assessed at different skeletal sites // J. Bone Miner. Res. 1993. V. 8. P. 1227-1233.
2. Audi L., Garcia-Ramirez M., Carrascosa A. Genetic determinants of bone mass // Horm. Res. 1999. V. 51. P. 105-123.
3. Spector T., Keen R., Arden N. et al. Influence of vitamin receptor genotype on bone mineral density in postmenopausal women; a twin study in Britain // BMJ. 1995. V. 310. P. 1357-1360.
4. Ralston S. The genetics of osteoporosis // Bone. 1999. V. 25. P. 85-86.
5. Eisman J. Genetics of osteoporosis // Endocr. Rev. 1999. V. 20. P. 788-804.
6. Grant S., Reid D., Blake G. et al. Reduced bone density and osteoporosis associated with a polymorphic Sp1 binding site in the collagen type I alpha 1 gene // Nat. Genet. 1996. V. 14. P. 203-205.
7. Uitterlinden A., Burger H., Huang Q. et al. Relation of alleles of the collagen type I alpha1 gene to bone density and the risk of osteoporotic fractures in postmenopausal women // N. Engl. J. Med. 1998. V. 338. P. 1016-1021.
8. Hobson E., Dean V., Grant S., Ralston S.H. Functional effects of a polymorphism of collagen (I) alpha 1 gene (Col1A1) in osteoporosis // J. Med. Genet. 1998. V. 35. P. 32.
9. Langdahl B., Ralston S., Grant S., Eriksen E. An Sp1 binding site polymorphism in the COL1A1 gene predicts osteoporotic fractures in both men and women // J. Bone Miner. Res. 1998. V. 13. P. 1384-1389.
10. Mc Guigan F., Reid D., Ralston S. Susceptibility to osteoporotic fracture is determined by allelic variation at the Sp1 site, rather than other polymorphic sites at the COL1A1 locus // Osteoporos Int. 2000. V. 11. P. 338-343.
11. Keen R., Woodford-Richens K., Grant S. et al. Association of polymorphism at the type I collagen (COL1A1) locus with reduced bone mineral density, increased fracture risk, and increased collagen turnover // Arthritis Rheum. 1999. V. 42. No 2. P. 285-290.
12. Weichetova M., Stepan J., Michalska D. et al. Col1A1 polymorphism contributes to bone mineral density to assess prevalent wrist fractures // Bone. 2000. V. 26. P. 287-290.
13. Han K., Moon I., Hwang C. et al. Lack of an intronic Sp1 binding-site polymorphism at the collagen type I alpha1 gene in healthy Korean women // Bone. 1999. V. 24. P. 135-137.
14. Dalqleish R. The human type I collagen mutation database // Nucl. Acids Res. 1997. V. 25. P. 181-187.
15. Garnero P., Borel O., Grant S. et al. Collagen Ialpha1 Sp1 polymorphism, bone mass, and bone turnover in healthy French premenopausal women: the OFELY study // J. Bone Miner. Res. 1998. V. 13. P. 813-817.
16. Nakajima T., Ota N., Shirai Y. et al. Ethnic difference in contribution of Sp1 site variation of COL1A1 gene in genetic predisposition to osteoporosis // Clacif. Tissue Int. 1999. V. 65. P. 352-353.