Protective effect of trimetazidine in a model of ischemia-reperfusion in the rat retina

Ophthalmic Research

Volumn 34, Issue 5, 2002, Pages 300-305

  Mohand Said, Saddek ^a,d   Jacquet, A ^b   Lucien, A ^b   Espinasse Berrod, M A ^c   Frasson Correa De Silva, M ^a   Sahel, J ^a  

^a UNIVERSITÉ DE STRASBOURG   (France)

^b INSTITUT DE RECHERCHES INTERNATIONALES SERVIER   (France)

^c HÔPITAL NECKER ENFANTS MALADES   (France)

^d EMI 99 18   (France)

Author keywords

Histomorphological study; Rat; Retinal ischemia; Trimetazidine

Indexed keywords

TRIMETAZIDINE;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL COUNT; CONTROLLED STUDY; DRUG EFFECT; HISTOPATHOLOGY; INTRAOCULAR PRESSURE; NONHUMAN; PRIORITY JOURNAL; RAT; REPERFUSION INJURY; RETINA ISCHEMIA; STATISTICAL SIGNIFICANCE;

ANIMALS; CYTOPROTECTION; ISCHEMIA; RATS; REPERFUSION INJURY; RETINAL VESSELS; TIME FACTORS; TRIMETAZIDINE; VEHICLES;

EID: 0036977832     PISSN: 00303747     EISSN: None     Source Type: Journal    
DOI: 10.1159/000065603     Document Type: Article

References (21)

1. Clauser P, Labrid C, Freyria JL, Poirier JP: Trimetazidine, a cellular anti-ischemic agent. Cardiovasc Drug Rev 1989;6:292-312.
2. Lavanchy N, Martin J, Rossi A: Anti-ischemic effects of trimetazidine: 31P NMR spectroscopy in the isolated rat heart. Arch Int Pharmacodyn Ther 1987;286:97-110.
3. Kay L, Finelli C, Aussedat J, Guarnieri C, Ros-si A: Improvement of long-term preservation of the isolated arrested rat heart by trimetazidine: Effects of the energy state and mitochondrial function. Am J Cardiol 1995;76:45B-49B.
4. Détry JM, Sellier P, Pennaforte S, Cokkinos D, Dargie M, Mathes P: Vastarel 20 mg: A new concept in the treatment of angina: Comparison with propranolol in patients with stable angina. Br J Clin Pharmacol 1994;37:279-288.
5. Kluyskens P, Lambert P, Dhooge D: Trimetazidine versus betahistine in vestibular vertigo: Double-blind study. Drugs Today 1990;26(suppl 8):13-22.
6. Morgon A: A two-month multicenter double-blind, placebo-controlled study of trimetazidine in tinnitus: Results obtained after two months of treatment. Drugs Today 1990;26(suppl 8):90-95.
7. Aron-Rosa D, Hullo A, Roeder P: Etude multi-centrique à double insu de la trimétazidine contre placebo dans les syndromes ischémiques rétiniens. Ophthalmol Fr 1987;28-36.
8. Michon JJ, Li ZL, Shioura N, Anderson RJ, Tso MOM: A comparative study of methods of photoreceptor morphometry. Invest Ophthalmol Vis Sci 1991;32:280-284.
9. Hughes WH: Quantification of ischemic damage in the rat retina. Exp Eye Res 1990;53:573-582.
10. Büchi ER, Suivaizdis I, Fu J: Pressure-induced retinal ischemia in rats: An experimental model for quantitative study. Ophthalmologica 1991;203:138-147.
11. Weber M, Mohand-Said S, Hicks D, Dreyfus H, Sahel JA: Monosialoganglioside GM1 reduces ischemia-reperfusion-induced injury in the rat retina. Invest Ophthalmol Vis Sci 1996;37:267-273.
12. Hamassaki-Britto DE, Hermans-Borgmeyer I, Heinemann S, Hughes TE: Expression of glutamate receptor genes in the mammalian retina: The localisation of Glu.R-1 through Glu.-7 mRNA. J Neurosci 1993;13:1888-1898.
13. Brandstäter JH, Hartveit E, Sassoè-Pognetto M, Wässle H: Expression of NMDA and high-affinity kainate receptor subunit mRNAs in the adult rat retina. Eur J Neurosci 1994;6:1100-1112.
14. Joo CK, Choi JS, Ko HW, et al: Necrosis and apoptosis after retinal ischemia: Involvement of NMDA-mediated excitotoxicity and p53. Invest Ophthalmol Vis Sci 1999;40:713-720.
15. Selles-Navarro I, Villegas-Perez MP, Salvador-Silva M, et al: Retinal ganglion cell death after different transient periods of pressure-induced ischemia and survival intervals: A quantitative in vivo study. Invest Ophthalmol Vis Sci 1996;37:2002-2014.
16. Choi D, Maulucci-Gedde M, Kriegstein AR: Glutamate neurotoxicity in cortical cell culture. J Neurosci 1987;7:357-358.
17. Manew H, Favaron M, Guidotti A, Costa E: Delayed increase of Ca2+ influx elicited by glutamate: Role in neuronal death. Mol Pharmacol 1989;36:106-112.
18. Elena PP, Khosravie Lapalus P, et al: Pharmacokinetics of trimetazidine in the pigmented rat after a single oral administration. Exp Eye Res 1992(suppl 1):555.
19. Maridonneau-Parini I, Harpey C: Effect of trimetazidine on membrane induced by oxygen free radicals in human red cells. Br J Clin Pharmacol 1985;20:148-151.
20. Delbarre B, Delbarre G, Calinon F: Action of trimetazidine on retina gerbils after ischemia reperfusion insult: Determination of OH, aminoacids, and electroretinogram. Ann N Y Acad Sci 1994;738:334-340.
21. Ozden S, Kildaci B, Muftuoglu S, Cakar N, Yildirim C: Effect of trimetazidine on retinal ischemia/reperfusion injury in rats. Ophthalmologica 2001;215:309-317.