Localization of lens intrinsic membrane protein MP19 and mutant protein MP19To3 using flourescent expression vectors

Molecular Vision

Volumn 8, Issue , 2002, Pages 372-388

  Chen, Tong ^a   Li, XianLian ^a,b   Yang, Yu ^a   Church, Robert L ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ZHENGZHOU UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; GREEN FLUORESCENT PROTEIN; HYBRID PROTEIN; LENS PROTEIN; MEMBRANE PROTEIN; MUTANT PROTEIN; PROTEIN MP19; RED FLUORESCENT PROTEIN; SIGNAL PEPTIDE; TETRACYCLINE; UNCLASSIFIED DRUG;

5' UNTRANSLATED REGION; ANIMAL CELL; ANIMAL CELL CULTURE; ARTICLE; CATARACT; CELL MEMBRANE TRANSPORT; CELLULAR DISTRIBUTION; CHICK EMBRYO; CONFOCAL MICROSCOPY; CONTROLLED STUDY; EMBRYO; EPITHELIUM CELL; EXPRESSION VECTOR; FLUORESCENCE; FLUORESCENCE MICROSCOPY; GENE MUTATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HUMAN EMBRYO; ISOLATION PROCEDURE; LENS EPITHELIUM; MAMMAL CELL; MICROPHTHALMIA; MOLECULAR CLONING; NONHUMAN; PLASMID; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN TRANSPORT;

ANIMALS; BIOLOGICAL TRANSPORT; CATARACT; CELL LINE; CELL MEMBRANE; CHICK EMBRYO; EPITHELIAL CELLS; EYE PROTEINS; GENETIC VECTORS; GREEN FLUORESCENT PROTEINS; HUMANS; LENS, CRYSTALLINE; LUMINESCENT PROTEINS; MEMBRANE GLYCOPROTEINS; MEMBRANE PROTEINS; MICROPHTHALMOS; MUTATION; RECOMBINANT FUSION PROTEINS; TRANSFECTION;

EID: 0036976925     PISSN: 10900535     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Rao GN, Gutekunst KA, Church RL. Bovine lens 23, 21 and 19 kDa intrinsic membrane proteins have an identical amino-terminal amino acid sequence. FEBS Lett 1989; 250:483-6.
2. Church RL, Wang JH. The human lens fiber-cell intrinsic membrane protein MP19 gene: isolation and sequence analysis. Curr Eye Res 1993; 12:1057-65.
3. Louis CF, Hur KC, Galvan AC, TenBroek EM, Jarvis LJ, Eccleston ED, Howard JB. Identification of an 18,000-dalton protein in mammalian lens fiber cell membranes. J Biol Chem 1989; 264:19967-73.
4. Voorter CE, Kistler J, Gruijters WT, Mulders JW, Christie D, de Jong WW. Distribution of MP17 in isolated lens fibre membranes. Curr Eye Res 1989; 8:697-706.
5. Mulders JW, Voorter CE, Lamers C, de Haard-Hoekman WA, Montecucco C, van de Ven WJ, Bloemendal H, de Jong WW. MP17, a fiber-specific intrinsic membrane protein from mammalian eye lens. Curr Eye Res 1988; 7:207-19.
6. Louis CF, Hogan P, Visco L, Strasburg G. Identity of the calmodulin-binding proteins in bovine lens plasma membranes. Exp Eye Res 1990; 50:495-503.
7. Gonen T, Donaldson P, Kistler J. Galectin-3 is associated with the plasma membrane of lens fiber cells. Invest Ophthalmol Vis Sci 2000; 41:199-203.
8. Gonen T, Grey AC, Jacobs MD, Donaldson PJ, Kistler J. MP20, the second most abundant lens membrane protein and member of the tetraspanin superfamily, joins the list of ligands of galectin-3. BMC Cell Biol 2001; 2:17.
9. Tenbroek E, Arneson M, Jarvis L, Louis C. The distribution of the fiber cell intrinsic membrane proteins MP20 and connexin46 in the bovine lens. J Cell Sci 1992; 103:245-57.
10. TenBroek EM, Johnson R, Louis CF. Cell-to-cell communication in a differentiating ovine lens culture system. Invest Ophthalmol Vis Sci 1994; 35:215-28.
11. Steele EC Jr, Kerscher S, Lyon MF, Glenister PH, Favor J, Wang J, Church RL. Identification of a mutation in the MP19 gene, Lim2, in the cataractous mouse mutant To3. Mol Vis 1997; 3:5.
12. Steele EC Jr, Wang JH, Lo WK, Saperstein DA, Li X, Church RL. Lim2(To3) transgenic mice establish a causative relationship between the mutation identified in the lim2 gene and cataractogenesis in the To3 mouse mutant. Mol Vis 2000; 6:85-94 .
13. Pras E, Levy-Nissenbaum E, Bakhan T, Lahat H, Assia E, Geffen-Carmi N, Frydman M, Goldman B, Pras E. A missense mutation in the LIM2 gene is associated with autosomal recessive presenile cataract in an inbred Iraqi Jewish family. Am J Hum Genet 2002; 70:1363-7.
14. Borras T, Peterson CA, Piatigorsky J. Evidence for positive and negative regulation in the promoter of the chicken delta 1-crystallin gene. Dev Biol 1988; 127:209-19.
15. Ibaraki N, Chen SC, Lin LR, Okamoto H, Pipas JM, Reddy VN. Human lens epithelial cell line. Exp Eye Res 1998; 67:577-85.
16. Skene JH, Virag I. Posttranslational membrane attachment and dynamic fatty acylation of a neuronal growth cone protein, GAP-43. J Cell Biol 1989; 108:613-24.
17. Watzele G, Berger EG. Near identity of HeLa cell galactosyltransferase with the human placental enzyme. Nucleic Acids Res 1990; 18:7174.
18. Zhou L, Li X, Church RL. The mouse lens fiber-cell intrinsic membrane protein MP19 gene (Lim2) and granule membrane protein GMP-17 gene (Nkg7): Isolation and sequence analysis of two neighboring genes. Mol Vis 2001; 7:79-88 .
19. Ladinsky MS, Mastronarde DN, McIntosh JR, Howell KE, Staehelin LA. Golgi structure in three dimensions: functional insights from the normal rat kidney cell. J Cell Biol 1999; 144:1135-49.
20. Klumperman J, Schweizer A, Clausen H, Tang BL, Hong W, Oorschot V, Hauri HP. The recycling pathway of protein ERGIC-53 and dynamics of the ER-Golgi intermediate compartment. J Cell Sci 1998; 111:3411-25.
21. Schweizer A, Ericsson M, Bachi T, Griffiths G, Hauri HP. Characterization of a novel 63 kDa membrane protein. Implications for the organization of the ER-to-Golgi pathway. J Cell Sci 1993; 104:671-83.
22. Hauri HP, Kappeler F, Andersson H, Appenzeller C. ERGIC-53 and traffic in the secretory pathway. J Cell Sci 2000; 113:587-96.
23. Gilbert A, Jadot M, Leontieva E, Wattiaux-De Coninck S, Wattiaux R. Delta F508 CFTR localizes in the endoplasmic reticulum-Golgi intermediate compartment in cystic fibrosis cells. Exp Cell Res 1998; 242:144-52.
24. Chiti F, Taddei N, Bucciantini M, White P, Ramponi G, Dobson CM. Mutational analysis of the propensity for amyloid formation by a globular protein. EMBO J 2000; 19:1441-9.
25. Walsh DM, Klyubin I, Fadeeva JV, Cullen WK, Anwyl R, Wolfe MS, Rowan MJ, Selkoe DJ. Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo. Nature 2002; 416:535-9.
26. Fandrich M, Fletcher MA, Dobson CM. Amyloid fibrils from muscle myoglobin. Nature 2001; 410:165-6.
27. Ellis RJ, Pinheiro TJ. Medicine: danger--misfolding proteins. Nature 2002; 416:483-4.
28. Bucciantini M, Giannoni E, Chiti F, Baroni F, Formigli L, Zurdo J, Taddei N, Ramponi G, Dobson CM, Stefani M. Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases. Nature 2002; 416:507-11.
29. Helenius A. Quality control in the secretory assembly line. Philos Trans R Soc Lond B Biol Sci 2001; 356:147-50.
30. Graw J. Cataract mutations and lens development. Prog Retin Eye Res 1999; 18:235-67.
31. Shiels A, Bassnett S. Mutations in the founder of the MIP gene family underlie cataract development in the mouse. Nat Genet 1996; 12:212-5.
32. Sidjanin DJ, Parker-Wilson DM, Neuhauser-Klaus A, Pretsch W, Favor J, Deen PM, Ohtaka-Maruyama C, Lu Y, Bragin A, Skach WR, Chepelinsky AB, Grimes PA, Stambolian DE. A 76-bp deletion in the Mip gene causes autosomal dominant cataract in Hfi mice. Genomics 2001; 74:313-9.