A novel class of endothelin-A receptor antagonists, (R)-2-(benzo[1,3]dioxol-5-yl)-6-isopropyloxy-2H-chromene-3-carboxylic acids (S-1255). Conformational analysis of basic structure, crucial for ETA antagonism, in solution and solid states

Bioorganic and Medicinal Chemistry

Volumn 10, Issue 12, 2002, Pages 3965-3972

  Ishizuka, Natsuki ^a   Matsumura, Ken Ichi ^a   Kikuchi, Junko ^a   Nakai, Hiroshi ^a  

^a SHIONOGI AND CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2 (1,3 BENZODIOXOL 5 YL) 6 ISOPROPYL 4 (4 METHOXYPHENYL) 2H CHROMENE 3 CARBOXYLIC ACID; 2 (BENZO[1,3]DIOXOL 5 YL) 6 ISOPROPYLOXY 2H CHROMENE 3 CARBOXYLIC ACID; ENDOTHELIN A RECEPTOR; ENDOTHELIN A RECEPTOR ANTAGONIST; UNCLASSIFIED DRUG;

ARTICLE; DRUG BINDING; DRUG CONFORMATION; DRUG POTENCY; DRUG RECEPTOR BINDING; MOLECULAR MECHANICS; MOLECULAR RECOGNITION; NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

ACIDS, HETEROCYCLIC; ANIMALS; AORTA; CRYSTALLOGRAPHY, X-RAY; INHIBITORY CONCENTRATION 50; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; MUSCLE, SMOOTH, VASCULAR; RATS; RECEPTOR, ENDOTHELIN A; RECEPTORS, ENDOTHELIN; SOLUTIONS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0036973439     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(02)00300-0     Document Type: Article

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