Reexamination of the stoichiometry of Na+/Ca2+ exchange with whole-cell voltage clamp of guinea pig ventricular myocytes

Annals of the New York Academy of Sciences

Volumn 976, Issue , 2002, Pages 154-156

  Hinata, Masamitsu ^a   Yamamura, Hisao ^b   Li, Libing ^a   Watanabe, Yasuhide ^a   Watano, Tomokazu ^a   Imaizumi, Yuji ^b   Kimura, Junko ^a  

^a FUKUSHIMA MEDICAL UNIVERSITY   (Japan)

^b NAGOYA CITY UNIVERSITY   (Japan)

Author keywords

Na Ca exchange; Ventricular myocytes; Whole cell voltage clamp

Indexed keywords

SODIUM CALCIUM EXCHANGE PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; CALCIUM CURRENT; CONFERENCE PAPER; CONTROLLED STUDY; GUINEA PIG; HEART MUSCLE CELL; ISOLATED HEART; NONHUMAN; PATCH CLAMP; SODIUM CALCIUM EXCHANGE; SODIUM CURRENT; STOICHIOMETRY; VOLTAGE CLAMP;

ANIMALIA; CAVIA PORCELLUS; SUS SCROFA;

EID: 0036971287     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2002.tb04735.x     Document Type: Conference Paper

References (9)

1. MULLINS, L.J. 1977. A mechanism for Na/Ca transport. J. Gen. Physiol. 70: 681-695.
2. PITTS, B.J. 1979. Stoichiometry of sodium-calcium exchange in cardiac sarcolemmal vesicles. Coupling to the sodium pump. J. Biol. Chem. 254: 6232-6235.
3. AXELEN, P.H. & J.H.B. BRIDGE. 1985. Electrochemical ion gradients and the Na/Ca exchange stoichiometry. Measurements of these gradients are thermodynamically consistent with a stoichiometric coefficient ≥3. J. Gen. Physiol. 85: 471-475.
4. KIMURA, J., S. MIYAMAE & A. NOMA. 1987 Identification of sodium-calcium exchange current in single ventricular cells of guinea-pig. J. Physiol. 384: 199-222.
5. 2+ exchange current in single guinea-pig ventricular cells. J. Physiol. 410: 227-249.
6. YASUI, K. & J. KIMURA. 1990. Is potassium co-transported by the cardiac Na-Ca exchange? Pfügers Arch. 415: 513-515.
7. BLAUSTEIN, M.P. & W.J. LEDERER. 1999. Sodium/calcium exchange: its physiological implications. Physiol. Rev. 79: 763-854.
8. 2+ exchange in inside-out patches excised from guinea-pig ventricular myocytes. J. Physiol. 523: 339-351.
9. + exchange is 3:1 in guinea-pig ventricular myocytes. J. Physiol. In press.