Dopamine receptor blockade in the rat medial prefrontal cortex reduces spontaneous and amphetamine-induced activity and does not affect prepulse inhibition

Behavioural Pharmacology

Volumn 13, Issue 8, 2002, Pages 669-673

  Bast, T ^b   Pezze, M A ^b   Feldon, J ^a  

^a ETH ZURICH   (Switzerland)

^b NONE

Author keywords

Activity; Amphetamine; Cis flupenthixol; Dopamine; Medial prefrontal cortex; Prepulse inhibition; Rat; Schizophrenia; Sensorimotor gating

Indexed keywords

DEXAMPHETAMINE; DOPAMINE RECEPTOR; DOPAMINE RECEPTOR BLOCKING AGENT; FLUPENTIXOL;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOPAMINE RECEPTOR BLOCKING; DRUG EFFECT; MALE; MOTOR ACTIVITY; NONHUMAN; NUCLEUS ACCUMBENS; PREFRONTAL CORTEX; PREPULSE INHIBITION; RAT; SCHIZOPHRENIA; STARTLE REFLEX;

EID: 0036971129     PISSN: 09558810     EISSN: None     Source Type: Journal    
DOI: 10.1097/00008877-200212000-00010     Document Type: Article

References (30)

1. Ahlenius S, Hillegaart V, Thorell G, Magnusson O, Fowler CJ (1987). Suppression of exploratory locomotor activity and increase in dopamine turnover following the local application of cis-flupenthixol into limbic projection areas of the rat striatum. Behav Brain Res 402:131-138.
2. Ahlheid GF, Heimer L (1996). Theories of basal forebrain organization and the emotional motor system. Prog Brain Res 107:461-484.
3. A receptor antagonist picrotoxin. Psychopharmacology 156:225-233.
4. Bast T, Zhang W-N, Feldon J (2001b). The ventral hippocampus and fear conditioning in rats: different anterograde amnesias of fear after tetrodotoxin inactivation and infusion of the GABAA agonist muscimol. Exp Brain Res 139:39-52.
5. Bast T, Zhang W-N, Ferger G, Feldon J. Post mortem study of changes in forebrain dopamine and serotanin transmission induced by ventral hippocampal N-methy-D asparate stimulation in rats: evidence for an activation of dopamine transmission in the medial prefrontal contex. Synapse (submitted).
6. Bast T, Zhang W-N, Heidbreder C, Feldon J (2001c). Hyperactivity and disruption of prepulse inhibition induced by N-methyl-D-aspartate stimulation of the ventral hippocampus and the effects of pretreatment with haloperidol and clozapine. Neuroscience 101:325-335.
7. Beninger RJ, Musgrave MA, Dickson PA (1990). Unilateral injections of a D2 but not D1 agonist into the frontal cortex of rats produce a contralateral directional bias. Pharmacol Biochem Behav 37:387-392.
8. Boye SM, Grant RJ, Clarke PBS (2001). Disruption of dopaminergic neurotransmission in nucleus accumbens core inhibits the locomotor stimulant effects of nicotine and D-amphetamine in rats. Neuropharmacology 40:792-805.
9. Deutch AY (1992). The regulation of subcortical dopamine systems by the prefrontal cortex: interactions of central dopamine systems and the pathogenesis of schizophrenia. J Neural Transm (Suppl.) 36:61-89.
10. Duvauchelle CL, Levitin M, MacConell LA, Lee LK, Ettenberg A (1992). Opposite effects of prefrontal cortex and nucleus accumbens infusions of flupenthixol on stimulant-induced locomotion and brain stimulation reward. Brain Res 576: 104-110.
11. Ellenbroek BA, Budde S, Cools AR (1996). Prepulse inhibition and latent inhibition: the role of dopamine in the medial prefrontal cortex. Neuroscience 75:535-542.
12. Floresco SB, Blaha CD, Yang CR, Phillips AG (2001). Modulation of hippocampal and amygdalar-evoked activity of nucleus accumbens neurons by dopamine: cellular mechanisms of input selection. J Neurosci 21:2851-2860.
13. Gurden H, Takita M, Jay TM (2000). Essential role of D1 but not D2 receptors in the NMDA receptor-dependent long-term potentation at hippocampal-prefrontal cortex synapses. J Neurosci 20:RC106 (1-5).
14. Hart S, Zreik M, Carper R, Swerdlow NR (1998). Localizing haloperidol effects on sensorimotor gating in a predictive model of antipsychotic potency. Pharmacol Biochem Behav 61:113-119.
15. Koch M (1999). The neurobiology of startle. Prog Neurobiol 59:107-128.
16. Lacroix L, Broersen LM, Feldon J, Weiner I (2000). Effects of local infusion of dopaminergic drugs into the medial prefrontal cortex of rats on latent inhibition, prepulse inhibition and amphetamine induced activity. Behav Brain Res 107:111-121.
17. Legault M, Wise RA (1999). Injections of N-methyl-D-aspartate into the ventral hippocampus increase extracellular dopamine in the ventral tegmental area and the nucleus accumbens. Synapse 31:241-249.
18. Mitchell SN, Yee BK, Feldon J, Gray JA, Rawlins JNP (2000). Activation of the retrohippocampal region in the rat causes dopamine release in the nucleus accumbens: disruption by fornix section. Eur J Pharmacol 407:131-138.
19. Myers RD (1966). Injection of solutions into cerebral tissue: relation between volume and diffusion. Physiol Behav 1:171-174.
20. Paxinos G, Watson C (1998). The rat brain in stereotaxic coordinates. 4th ed. San Diego: Academic Press.
21. Pezze M, Bast T, Feldon J (2001). Effects of dopamine receptor stimulation or blockade in the medial prefrontal cortex on locomotor activity, sensorimotor gating, and conditioned fear [abstract]. Behav Pharmacol 12(Suppl. 1):S77.
22. Pezze M, Bast T, Feldon J (2003). Significance of dopamine transmission in the rat in mPFC for conditioned fear. Cereb Cortex (in press).
23. Pycock CJ, Kerwin RW, Carter CJ (1980). Effects of lesion of cortical dopamine terminals on subcortical dopamine receptors in rats. Nature 286:74-77.
24. Routtenberg A (1972). Intracranial chemical injection and behavior: a critical review. Behav Biol 7:601-641.
25. Swerdlow NR, Braff DL, Masten VL, Geyer MA (1990). Schizophrenic-like sensorimotor gating abnormalities in rats following dopamine infusion into the nucleus accumbens. Psychopharmacology 101:414-420.
26. Tzschentke TM (2001). Pharmacology and behavioral pharmacology of the mesocortical dopamine system. Prog Neurobiol 63:241-320.
27. Vezina P, Blanc G, Glowinski J, Tassin J-P (1991). Opposed behavioural outputs of increased dopamine transmission in prefrontocortical and subcortical areas: a role for the cortical D-1 dopamine receptor. Eur J Neurosci 3:1001-1007.
28. Weinberger DR, Egan MF, Bertolino A, Callicot JH, Mattay VS, Lipska BK, et al. (2001). Prefrontal neurons and the genetics of schizophrenia. Biol Psychiatry 50:825-844.
29. Wu M, Brudzynski SM (1995). Mesolimbic dopamine terminals and locomotor activity induced from the subiculum. Neuroreport 6:1601-1604.
30. Yang CR, Seamans JK, Gorelova N (1999). Developing a neuronal model for the pathophysiology of schizophrenia based on the nature of electrophysiological actions of dopamine in the prefrontal cortex. Neuropsychopharmacology 21:161-194.