A dose-escalation study of oxaliplatin and vinorelbine in patients with advanced solid tumors

Oncology

Volumn 63, Issue 3, 2002, Pages 213-218

  Kakolyris, Stylianos ^a   Kouroussis, C ^a   Koukourakis, M ^a   Marvroudis, D ^a   Malas, K ^a   Vardakis, N ^a   Bozionelou, V ^a   Kalbakis, K ^a   Georgoulias, V ^a  

^a UNIVERSITY HOSPITAL OF HERAKLION   (Greece)

Author keywords

Oxaliplatin; Solid tumors; Vinorelbine

Indexed keywords

NAVELBINE; OXALIPLATIN;

ADULT; AGED; ANEMIA; ARTICLE; ASTHENIA; BREAST CANCER; CANCER COMBINATION CHEMOTHERAPY; CANCER SURVIVAL; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DRUG INFUSION; DYSESTHESIA; FEMALE; HUMAN; LUNG NON SMALL CELL CANCER; MALE; MUCOSA INFLAMMATION; MUSCLE CRAMP; NAUSEA; NEUROTOXICITY; NEUTROPENIA; OVARY CANCER; PARESTHESIA; PERFORMANCE; PHASE 1 CLINICAL TRIAL; PRIORITY JOURNAL; THROMBOCYTOPENIA; TREATMENT FAILURE; TREATMENT OUTCOME; VOMITING;

ADULT; AGED; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BREAST NEOPLASMS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; INFUSIONS, INTRAVENOUS; LUNG NEOPLASMS; MALE; MAXIMUM TOLERATED DOSE; MIDDLE AGED; ORGANOPLATINUM COMPOUNDS; OVARIAN NEOPLASMS; SALVAGE THERAPY; TREATMENT OUTCOME; VINBLASTINE;

EID: 0036966940     PISSN: 00302414     EISSN: None     Source Type: Journal    
DOI: 10.1159/000065467     Document Type: Article

References (16)

1. Raymond E, Faivre S, Woynarowski JM, Chaney SG: Oxaliplatin: Mechanism of action and antineoplastic activity. Semin Oncol 1998; 25(suppl 5):4-12.
2. Rixe O, Ortuzar W, Alvarez M, Parker R, Reed E, Paull K, Fojo T: Oxaliplatin, tetraplatin, cisplatin, and carboplatin: Spectrum of activity in drug-resistant cell lines and in the cell lines of the National Cancer Institute's Anticancer Drug Screen Panel. Biochem Pharmacol 1996; 52:1855-1865.
3. Woynarowski JM, Chapman WG, Napier C: Oxaliplatin effects on naked and intracellular DNA (abstract A2083). Proc Am Assoc Cancer Res 1997;38:311.
4. Bleiberg H: Oxaliplatin (L-OHP): A new reality in colorectal cancer. Br J Cancer 1998;7(suppl 4):1-3.
5. Cvitkovic E: Ongoing and unsaid on oxaliplatin: The hope. Br J Cancer 1996;77(suppl 4): 8-11.
6. Extra JM, Marty M, Brienza S, Misset JL: Pharmacokinetics and safety profile of oxaliplatin. Semin Oncol 1998;25(suppl 5):13-22.
7. Extra JM, Espie M, Calvo F, Ferme C, Mignot L, Marty M: Phase I study of oxaliplatin in patients with advanced cancer. Cancer Chemother Pharmacol 1990;25:299-303.
8. Canobbio L, Boccardo F, Pastorino G: Phase II study of navelbine in advanced breast cancer. Semin Oncol 1989;16/4:33-36.
9. Depierre A, Lemarie E, Dabouis G, Garnier G, Jacoulet P, Dalphin JC: A phase II study of navelbine in the treatment of non-small cell lung cancer. Am J Clin Oncol 1991;14:115-119.
10. George MJ, Heron JF, Kerbrat P, Chauvergne J, Goupil A, Lebrum D, Guastalla JP, Namer M, Bugat R, Ayme Y: Navelbine in advanced ovarian epithelial cancer: A study of the French oncology centers. Semin Oncol 1989;16:30-32.
11. Le Chevalier T, Brisgand D, Douillard JY, Pujol JL, Alberola V, Monnier A, Riviere A, Lianes P, Chomy P, Cigolari S, Gottfried M, Ruffie P, Panizo A, Gaspard MH, Ravaioli A, Besenval M, Besson F, Martinez A, Berthand P, Tursz T: Randomized study of vinorelbine and cisplatin versus vindesine and cisplatin versus vinorelbine alone in advanced non-small cell lung cancer: Results of a European multicenter trial including 612 patients. J Clin Oncol 1994;12:360-367.
12. Caussanel JP, Levi F, Brienza S, Misset JL, Itzhaki M, Adam R, Milano G, Hecquet B, Mathe G: Phase I trial of 5-day continuous venous infusion of oxaliplatin at circardian rhythm modulated rate compared with constant rate. J Natl Cancer Inst 1990;82:1046-1050.
13. Miller AB, Hoogstraten BB, Staquet M, Winkler A: Reporting results of cancer treatment. Cancer 1981;47:207-214.
14. De Pierre A, Chastang C, Quoix E, Lebeau B, Blanchon F, Paillot N, Lemarie E, Milleron B, Moro D, Clavier J, Herman D, Tuchais E, Jacoulet P, Brechot JM, Cordier JF: Vinorelbine versus vinorelbine plus cisplatin in advanced non-small cell lung carcinoma. Ann Oncol 1994;5:37-42.
15. Monnet I, Soulier P, De Cremoux H, Saltiel-Voisin S, Bekradda M, Saltiel JC, Brain E, Dupont-Andre G, Cvitkovic E. Phase I/II study of escalating doses of vinorelbine in combination with oxaliplatin in patients with advanced non-small cell lung cancer (NSCLC). J Clin Oncol 2001;19:458-463.
16. Raymond E, Chaney SG, Taamma A, Cvitkovic E: Oxaliplatin: A review of preclinical and clinical studies. Ann Oncol 1998;9:1053-1071.