Suppression of adaptive immune responses: A novel mechanism by which peroxisome proliferators exert antiinflammatory effects?

Annals of the New York Academy of Sciences

Volumn 973, Issue , 2002, Pages 13-16

  Yang, Qian ^a   Xie, Yi ^a   DePierre, Joseph W ^a  

^a STOCKHOLM UNIVERSITY   (Sweden)

Author keywords

Adaptive immunosuppresion; Anti inflammatory; Peroxisome proliferator

Indexed keywords

PEROXISOME PROLIFERATOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA;

ANTIINFLAMMATORY ACTIVITY; CONFERENCE PAPER; IMMUNE RESPONSE; IMMUNE SYSTEM; IMMUNOSUPPRESSIVE TREATMENT; NONHUMAN;

EID: 0036964602     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2002.tb04599.x     Document Type: Conference Paper

References (9)

1. DEVCHAND, P.R., H. KELLER, J.M. PETERS, et al. 1996. The PPARalpha-leukotriene B4 pathway to inflammation control. Nature 384: 39-43.
2. FIEDLER, J., F.R. SIMON, M. IWAHASHI & R.C. MURPHY. 2001. Effect of peroxisome proliferator-activated receptor alpha activation on leukotriene B(4) metabolism in isolated rat hepatocytes. J. Pharmacol. Exp. Ther. 299: 691-697.
3. POWRIE, F. & R.L. COFFMAN. 1993. Cytokine regulation of T-cell function: potential for therapeutic intervention. Trends Pharmacol. Sci. 14: 164-168.
4. JANEWAY, C.A., P. TRAVERS, M. WALPORT & J.D. CAPRA. 1999. Immunobiology: The Immune System in Health and Disease. Garland Publishing. New York.
5. YANG, Q., Y. XIE & J.W. DEPIERRE. 2000. Effects of peroxisome proliferators on the thymus and spleen of mice. Clin. Exp. Immunol. 122: 219-226.
6. YANG, Q., Y. XIE, A.M. ERIKSSON, et al. 2001. Further evidence for the involvement of inhibition of cell proliferation and development in thymic and splenic atrophy induced by the peroxisome proliferator perfluoroctanoic acid in mice. Biochem. Pharmacol. 62: 1133-1140.
7. YANG, Q., M. ABEDI-VALUGERDI, Y. XIE, et al. 2002. Potent suppression of the adaptive immune response in mice upon dietary exposure to the potent peroxisome proliferator, perfluorooctanoic acid. Int. Immunopharmacol. 2: 389-397.
8. YANG, Q., Y. XIE, S.E.H. ALEXSON, et al. 2002. Involvement of the peroxisome proliferator-activated receptor alpha in the immunomodulation caused by peroxisome proliferators in mice. Biochem. Pharmacol. 63: 1893-1900.
9. HANSSON, G.K. 1997. Cell-mediated immunity in atherosclerosis. Curr. Opin. Lipidol. 8: 301-311.