Lysosomotropic N,N-dimethyl α-aminoacid n-alkyl esters and their quaternary ammonium salts as plasma membrane and mitochondrial ATPases inhibitors

Cellular and Molecular Biology Letters

Volumn 7, Issue 4, 2002, Pages 1121-1129

  Obła̧k, Ewa ^a   Lachowicz, Tadeusz M ^b   Łuczyński, Jacek ^c   Witek, Stanisław ^c  

^a UNIVERSITY OF WROC AW   (Poland)

^b UNIVERSITY OF ZIELONA GÓRA   (Poland)

^c WROCLAW UNIVERSITY OF TECHNOLOGY   (Poland)

Author keywords

H+ ATPase; Lysosomotropic Aminoesters; Proton Extrusion; Quaternary Ammonium Salts; Saccharomyces cerevisiae

Indexed keywords

ALANINE DERIVATIVE; DIMETHYLGLYCINE; GLYCINE DERIVATIVE; HEXAMETHONIUM BROMIDE; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE INHIBITOR; QUATERNARY AMMONIUM DERIVATIVE;

ANTIFUNGAL ACTIVITY; ARTICLE; CELL MEMBRANE; CONCENTRATION RESPONSE; DRUG MECHANISM; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; MINIMUM INHIBITORY CONCENTRATION; MITOCHONDRION; MUTANT; NONHUMAN; PH; SACCHAROMYCES CEREVISIAE; STRUCTURE ANALYSIS;

SACCHAROMYCES CEREVISIAE;

EID: 0036963821     PISSN: 14258153     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Lachowicz T.M., Obła̧k E. and Pia̧tkowski J. Auxotrophy - stimulated sensitivity to quaternary ammonium salts and its relation to active transport in yeast. Bul. Pol. Acad. Sci. 40 (1992) 173-182.
2. Obła̧k E., Ułaszewski S., Morawiecki A., Witek S., Witkowska R., Majcher K. and Lachowicz T.M. Quaternary ammonium salt resistant mutants in yeast Saccharomyces cerevisiae. Yeast 5 (Special Issue) (1989) 273-278.
3. Obła̧k E., Ułaszewski S. and Lachowicz T.M. Mutants of Saccharomyces cerevisiae resistant to a quaternary ammonium salt. Acta Microbiol. Polon. 37 (1988) 261-269.
4. Lachowicz T. M., Witkowska R. and Obła̧k E. Amino acid auxotrophy increases sensitivity of Saccharomyces cerevisiae to a quaternary ammonium salt IM. Acta Microbiol. Polon. 39 (1990) 157-162.
5. +-ATPase in yeast Saccharomyces cerevisiae. Cell. Biol. Mol. Lett. 5 (2000) 315-324.
6. Obła̧k E., Lachowicz T.M., Luczyfiski J.m and Witek S. Comparative studies of biological activities of the lysosomotropic aminoesters and quaternary ammonium salts on yeast Saccharomyces cerevisiae. Cell. Biol. Mol. Lett. 6 (2001) 871-880.
7. Thompson R., Amphiphilic glycine-based esters as soft antimicrobial agents, PhD Thesis, Goeteborg 1992
8. Słonimski P.P., Perodin G. and Crought J.H. Ethidium bromide induced mutation of yeast mitochondria: complete transformation of cells into respiratory deficient nonchromosal "petites". Biochem. Biophys. Res. Commun. 30 (1968) 232.
9. Sigler K., Knotkova A. and Kotyk A. Factors governing substrate induced generation and extrusion of protons in the yeast Saccharomyces cerevisiae. Biochim. Biophys. Acta. 643 (1981) 572-582.
10. Kotyk A. Mechanisms of extracellular acidification by yeast. J. Biophys. 3 (1993) 17-26.
11. Dufour J.P. and Goffeau A. Solubilization by lysolecithin and purification of the plasma membrane ATPase of the yeast Schizosaccharomyces pombe. J. Biol. Chem. 253 (1978) 7026-7032.
12. +-ATPase, and pdrl controlling multiple drug resistance in Saccharomyces cerevisiae. Acta Biochim. Polon. 40 (1993) 487-496.
13. Lowry O.H., Rosebrough N.J., Farr A.L. and Randall R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193 (1951) 265-275.
14. Górska-Poczopko J. and Witek S. Fungicidial properties of some new quaternary ammonium salts. Abh. Akad. Wiss. Deutch. (Berlin) 1 (1982) 271-275.
15. Rucka M., Oświȩcimska M. and Witek S. New biocides for cooling water treatment. III Quaternary ammonium salts derivatives of glycine esters. Envir. Protect. Eng. 9 No. 3 (1983) 25-31.
16. Obła̧k E., Lachowicz T.M. and Witek S. DL - leucine transport in a Saccharomyces cerevisiae mutant resistant to quaternary ammonium salts. Folia Microbiol. 41 (1996) 116-119.