Gene profiling approach to establish the molecular bases for partial versus full activation of naïve CD8 T lymphocytes

Annals of the New York Academy of Sciences

Volumn 975, Issue , 2002, Pages 68-76

  Verdeil, Grégory ^a   Puthier, Denis ^b   Nguyen, Catherine ^b   Schmitt Verhulst, Anne Marie ^a   Auphan Anezin, Nathalie ^a  

^a CENTRE D IMMUNOLOGIE DE MARSEILLE LUMINY   (France)

^b Aix Marseille university   (France)

Author keywords

CD8 T lymphocytes; Gene profiling; Partial agonist; Transcriptional regulation

Indexed keywords

ALLOANTIGEN; CD8 ANTIGEN; CHEMOKINE; CYTOKINE; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 2; MESSENGER RNA; PARTIAL AGONIST; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR AP 1; TUMOR ANTIGEN; VACCINE;

ANIMAL CELL; CONFERENCE PAPER; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXIC T LYMPHOCYTE; DNA FINGERPRINTING; DNA MICROARRAY; EFFECTOR CELL; GENE CLUSTER; GENE EXPRESSION REGULATION; IMMUNE RESPONSE; IMMUNOTHERAPY; MOLECULAR CLONING; MOUSE; NONHUMAN; T LYMPHOCYTE ACTIVATION; TRANSCRIPTION REGULATION; TRANSGENIC MOUSE; TUMOR CELL; VIRUS INFECTION;

ANIMALIA; MUS MUSCULUS;

EID: 0036963469     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2002.tb05942.x     Document Type: Conference Paper

References (17)

1. WELSH, R.M. 2001. Assessing CD8 T cell number and dysfunction in the presence of antigen. J. Exp. Med. 193: F19-F22.
2. + T cells by a self-derived peptide. Nature 378: 295-298.
3. SLOAN-LANCASTER, J. & P.M. ALLEN. 1996. Altered peptide ligand-induced partial T cell activation: molecular mechanisms and role in T cell biology. Annu. Rev. Immunol. 14: 1-27.
4. AUPHAN, N., S. GHOSH, R.A. FLAVELL & A.-M. SCHMITT-VERHULST. 1999. Differential requirements for NF-κB and AP-1 transactivation in response to minimal TCR engagement by a partial agonist in naïve CD8 T cells. J. Immunol. 163: 5219-5227.
5. AUPHAN, N., J. CURNOW, A. GUIMEZANES, et al. 1994. The degree of CD8 dependence of cytolytic T cell precursors is determined by the nature of the TCR and influences negative selection in TCR-transgenic mice. Eur. J. Immunol .24: 1572-1577.
6. BERNARD, K., N. AUPHAN, S. GRANJEAUD, et al. 1996. Multiplex messenger assay: simultaneous, quantitative measurement of expression of many genes in the context of T cell activation. Nucleic Acids Res. 24: 1435-1442.
7. BERTUCCI, F., K. BERNARD, B. LORIOD, et al. 1999. Sensitivity issues in DNA array-based expression measurements and performance of nylon microarrays for small samples. Hum. Mol. Genet. 8: 1715-1722.
8. EISEN, M.B., P.T. SPELLMAN; P.O. BROWN & D. BOTSTEIN. 1998. Cluster analysis and display of genome-wide expression patterns. Proc. Natl. Acad. Sci. USA 95: 14863-14868.
9. ORPHANIDES, G. & D. REINBERG. 2002. A unified theory of gene expression. Cell 108: 439-451.
10. LINDSTEN, T., C.H. JUNE, J.A. LEDBETTER, et al. 1989. Regulation of lymphokine messenger RNA stability by a surface-mediated T cell activation pathway. Science 244: 339-343.
11. CHEN, L., W. FISCHLE, E. VERDIN & W.C. GREENE. 2001. Duration of nuclear NF-κB action regulated by reversible acetylation. Science 293: 1653-1657.
12. THOMAS, D. & M. TYERS. 2000. Transcriptional regulation: kamikaze activators. Curr. Biol. 10: R341-R343.
13. Su, B., E. JACINTO, M. HIBI, et al. 1994. JNK is involved in signal integration during costimulation of T lymphocytes. Cell 77: 727-736.
14. CHTANOVA, T., R.A. KEMP, A.P. SUTHERLAND, et al. 2001. Gene microarrays reveal extensive differential gene expression in both CD4(+) and CD8(+) type 1 and type 2 T cells. J. Immunol. 167: 3057-3063.
15. + T cells. J. Immunol. 166: 7335-7344.
16. LECHNER, O., J. LAUBER, A. FRANZKE, et al. 2001. Fingerprints of anergic T cells. Curr. Biol. 11: 587-595.
17. MACIAN, F., F. GARCIA-COZAR, I. SIN-HYEOG, et al. 2002. Transcriptional mechanisms underlying lymphocyte tolerance. Cell 109: 719-731.