Costs of opioid therapy for chronic nonmalignant pain in Germany: An economic model comparing transdermal fentanyl (Durogesic) with controlled-release morphine

European Journal of Health Economics

Volumn 3, Issue 2, 2002, Pages 111-119

  Lehmann, K ^a   Radbruch, Lukas ^a,c   Gockel, H H ^d   Neighbors, D ^b   Nuyts, G ^d  

^a UNIVERSITY OF COLOGNE   (Germany)

^b RTI HEALTH SOLUTIONS   (United States)

^c UNIVERSITY HOSPITAL OF COLOGNE   (Germany)

^d NONE

Author keywords

Controlled release morphine; Economic model; Opioids; Quality adjusted life years; Transdermal fentanyl

Indexed keywords

FENTANYL; MORPHINE; OPIATE;

ARTICLE; CHRONIC PAIN; CONSTIPATION; CONTROLLED DRUG RELEASE; DRUG COST; DRUG EFFICACY; DRUG SAFETY; GERMANY; HEALTH ECONOMICS; HUMAN; MEDICAL DECISION MAKING; MODEL; NAUSEA; PAIN; PRIORITY JOURNAL; QUALITY ADJUSTED LIFE YEAR; RESPIRATION DEPRESSION; SOMNOLENCE; TREATMENT OUTCOME; VOMITING;

EID: 0036962714     PISSN: 16187598     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10198-002-0097-6     Document Type: Article

References (38)

1. Ahmedzai S, Brooks D (1997) Transdermal fentanyl versus sustained release morphine in cancer pain: preference, efficacy and quality of life. J Pain Symptom Manage 13:254-261
2. Ahmedzai S, Allan E, Fallon M, et al (1994) Transdermal fentanyl in cancer pain. J Drug Dev 6:93-97.
3. Allan L, Hays H, Jensen N-H, et al (2001) Randomised crossover trial of transdermal fentanyl and oral morphine in chronic non-cancer pain. BMJ 322:1154-1158
4. Anonymous (1999) Physician's desk reference. Medical Economics: Montvale
5. Bala MY, Wood LL, Zarkin GA, et al (1998) Valuing outcomes in health care: a comparison of willingness-to-pay and quality-adjusted life-years. J Clin Epidemiol 51:667-676
6. Bloor K, Leese B, Maynard A (1994) The costs of managing severe cancer pain and potential savings from transdermal administration. Eur J Cancer 30A:463-468
7. Broglie M, Schade H-J, Gerhardt G (1997) Gebührenhandbuch-Kommentare für Ärzte EBM GOÄ. Medical Tribune
8. Dellemijn PLI, van Duijn H, Vanneste JAL (1998) Prolonged treatment with transdermal fentanyl in neuropathic pain. J Pain Symptom Manage 16:220-229
9. Donner B, Zenz M, Tryba M, Strumpf M (1996) Direct conversion from oral morphine to transdermal fentanyl: a multicenter study in patients with cancer pain. Pain 64:527-534
10. Drossman DA, Corazziari E, Talley NJ, et al (1999) Rome II: a multinational consensus document on functional gastrointestinal disorders. Gut 45 [Suppl II]:1-81
11. Grond S, Zech D, Lehmann KA, et al (1997) Transdermal fentanyl in the long-term treatment of cancer pain: a prospective study of 50 patients with advanced cancer of the gastrointestinal tract orthe head and neck region. Pain 69:191-198
12. Grond S, Radbruch L, Lehmann KA (2000) Clinical pharmacokinetics of transdermal opioids. Focus on transdermal fentanyl. Clin Pharmacokinet 38:59-89.
13. Gureje O, Von Korff M, Simon G, Gater R (1998) Persistent pain and well-being: a World Health Organization study in primary care. JAMA 280:147-151
14. Hanks GW, de Conno F, Cherny N, et al (2001) Morphine and alternative opioids in cancer pain: the EAPC recommendations. Br J Cancer 85:587-593
15. Hannoveraner Konsens Gruppe (1999) Deutsche Empfehlungen zur gesundheitsökonomischen Evaluation - revidierte Fassung des Hannoveraner Konsens. Gesundheitsökon Qualitätsmanage 4:3, A62-A65
16. Iconomou G, Viha A, Vagenakis AG, Kalofonos HP (2000)Transdermal fentanyl in cancer patients with moderate-to-severe pain: a prospective examination. Anticancer Res 20:4821-4824
17. Jeal W, Benfield P (1997) Transdermal fentanyl. A review of its pharmacological properties and therapeutic efficacy in pain control. Drugs 53:109-138
18. Lehmann KA, Zech D (1992) Transdermal fentanyl: clinical pharmacology. J Pain Symptom Manage 7:S8-S16
19. Levy MH, Rosen SM, Kedziera P (1992) Transdermal fentanyl: seeding trial in patients with chronic cancer pain. J Pain Symptom Manage 7 [Suppl]:48-50
20. Liebau K (1999) Berufskunde für Heilpraktiker. Pflaum: Munich
21. Milligan K, Lanteri-Minet M, Borchert K, et al (2001) Evaluation of long-term efficacy and safety of transdermal fentanyl in the treatment of chronic non-cancer pain. J Pain 2:197-204
22. Neighbors DM, Bell TJ, Wilson J, Dodd SC (2001) Economic evaluation of the fentanyl transdermal system for the treatment of chronic moderate to severe pain. J Pain Symptom Manage 21:129-143
23. Newshan G, Lefkowitz M (2001) Transdermal fentanyl for chronic pain in AIDS: a pilot study. J Pain Symptom Manage 21:69-77
24. Payne R, Chandler S, Einhaus M (1995) Guidelines for the clinical use of transdermal fentanyl. Anticancer Drugs 6 [Suppl 3]:50-53
25. Radbruch L, Sabatowski R, Loick G, et al (2000) Constipation and the use of laxatives - a comparison between transdermal fentanyl and oral morphine. Palliat Med 14:111-119
26. Radbruch L, Sabatowski R, Petzke F, et al (2001) Transdermal fentanyl for the management of cancer pain - a survey of 1005 patients. Palliat Med 15:309-321
27. Roback B, Thirlwell M, Cowans M, et al (1995) Potential cost savings with fentanyl patches in comparison to oral or parenteral opioid: a pilot study. Presented at the American Pain Society General Meeting, September 1995, Montreal, Canada
28. Rote Liste Service GmbH (1999) Rote Liste 1999. Cantor: Aulendorf
29. Rote Liste Service GmbH (2000) Rote Liste 2000. Cantor: Aulendorf
30. Schofferman J (1993) Long term use of opioid analgesics for the treatment of chronic pain of nonmalignant origin. J Pain Symptom Manage 8:279-288
31. Simmonds MA (1995) Transdermal fentanyl: clinical development in the United States. Anticancer Drugs 6 [Suppl 3]:35-38
32. Simpson RK, Edmondson EA, Constant CF, Collier C (1997) Transdermal fentanyl as treatment for chronic low back pain. J Pain Symptom Manage 14:218-224
33. Slappendel R, Lako SJ, Crul BJP (1994) Gastrointestinal side effects diminish after switch over from morphine to transdermal fentanyl. Ann Oncol 5 [Suppl 8]:200
34. Slover R (1992) Transdermal fentanyl: clinical trial at the University of Colorado Health Sciences Center. J Pain Symptom Manage 7 [Suppl]:S45-S47
35. Tooley PJH, Cookson RF, Jones M, Nuyts GD (2000) Medical events and resource utilisation in cancer-pain patients treated with strong opioids: an analysis of the UK General Practice Database. J Outcomes Res 4:1-14
36. Woodroffe MA, Hays H (1997) Fentanyl transdermal system. Pain management at home. Can Fam Physician 43:268-272
37. Zech DFJ, Lehmann KA, Grond S (1994) A new treatment option for chronic cancer pain. Eur J Palliat Care 1:26-30
38. Zech M, Strumpf M, Tryba M (1992) Long-term oral opioid therapy in patients with chronic nonmalignant pain. J Pain Symptom Manage 7:69-77k