Total synthesis of a-tetracyclic anti-tumor, UCE6

Journal of Antibiotics

Volumn 55, Issue 12, 2002, Pages 1076-1080

  Tatsuta, Kuniaki ^a   Inukai, Takayuki ^a   Itoh, Sayaka ^a   Kawarasaki, Masataka ^a   Nakano, Yuko ^a  

^a WASEDA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; UCE 6; UNCLASSIFIED DRUG;

ACTINOMYCES; ANTINEOPLASTIC ACTIVITY; CHEMICAL REACTION; CONTROLLED STUDY; DRUG ISOLATION; DRUG STRUCTURE; DRUG SYNTHESIS; FERMENTATION MEDIUM; LETTER; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL;

EID: 0036956433     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.7164/antibiotics.55.1076     Document Type: Letter

References (9)

1. FUJII, N.; F. TANAKA, Y. YAMASHITA, T. ASHIZAWA, S. CHIBA & H. NAKANO: UCE6, a new antitumor antibiotic with topoisomerase I-mediated DNA cleavage activity produced by actinomycetes: producing organism, fermentation, isolation and biological activity. J. Antibiotics 50: 490-495, 1997
2. FUJII, N.; Y. YAMASHITA, S. CHIBA, Y. UOSAKI, Y. SAITOH, Y. TUJI & H. NAKANO: UCE6, a new antitumor antibiotic with topoisomerase I mediated DNA cleavage activity, from actinomycetes. J. Antibiotics 46: 1173-1174, 1993
3. TATSUTA, K.: Total syntheses of useful bioactive compounds. Adv. Synth. Catal. 343: 143-159, 2001
4. KELLY, T. R.; S. H. BELL, N OHASHI & R. J. ARMSTRONG-CHONG: Synthesis of (±)-fredericamycin A. J. Am. Chem. Soc. 110: 6471-6480, 1988
5. Liu, H.-J.; T. K. NGOOI & E. N. C. BROWNE: Diels-Alder reactions of 2-carbomethoxy-2-cyclohexen-1-one. Can. J. Chem. 66: 3143-3152, 1988
6. NICOLAOU, K. C.; Y.-L. ZHONG & P. S. BARAN: A new method for the one-step synthesis of α,β-unsaturated carbonyl systems from saturated alcohols and carbonyl compounds. J. Am. Chem. Soc. 122: 7596-7597, 2000
7. PATERSON, I.; J. M. GOODMAN, M. A. LISTER, R. C. SCHUMANN, C. K. MCCLURE & R. D. NORCROSS: Enantio- and diastereoselective aldol reactions of achiral ethyl and methyl ketones with aldehydes: the use of enol diisopinocampheylborinates. Tetrahedron 46: 4663-4684, 1990
8. NELSON, S. G.: Catalyzed enantioselective aldol additions of latent enolate equivalents. Tetrahedron: Asymmetry 9: 357-389, 1998
9. An authentic sample of natural UCE6 was kindly provided by Dr. Y. KANDA, Kyowa Hakko Kogyo Co., Ltd.