Is cardiomyopathy an autoimmune disease?

Keio Journal of Medicine

Volumn 51, Issue 4, 2002, Pages 208-212

  Fu, Michael ^a   Matsui, Shinobu ^b  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b KANAZAWA MEDICAL UNIVERSITY   (Japan)

Author keywords

Antibody; Autoimmunity; Cardiomyopathy; Receptors

Indexed keywords

AUTOANTIBODY; CARRIER PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; AUTOIMMUNE DISEASE; AUTOIMMUNITY; BRAIN VENTRICLE DILATATION; CARDIOMYOPATHY; CONFERENCE PAPER; CONGESTIVE CARDIOMYOPATHY; CONTROLLED STUDY; DISEASE SEVERITY; GENETIC SUSCEPTIBILITY; HEART FAILURE; HEART TRANSPLANTATION; NONHUMAN; RAT; SEROCONVERSION; VIRUS INFECTION;

EID: 0036952934     PISSN: 00229717     EISSN: None     Source Type: Journal    
DOI: 10.2302/kjm.51.208     Document Type: Conference Paper

References (59)

1. Fowles RE, Bieber CP, Stinson EB: Defective in vitro suppressor cell function in idiopathic congestive cardiomyopathy. Circulation 1979; 59: 483-491
2. Eckstein R, Mempel W, Bolte HD: Reduced suppressor cell activity in congestive cardiomyopathy and in myocarditis. Circulation 1982; 65: 1224-1229
3. Anderson JL, Carlquist JF, Hammond EH: Deficient natural killer cell activity in patients with idiopathic dilated cardiomyopathy. Lancet 1982; 2: 1124-1127
4. Sanderson JE, Koech D, Iha D, Ojiambo HP: T-lymphocyte subsets in idiopathic dilated cardiomyopathy. Am J Cardiol 1985; 55: 755-758
5. Rönnblom LE, Forsberg H, Evrin PE: Increased level of HLA-DR-expressing T lymphocytes in peripheral blood from patients with idiopathic dilated cardiomyopathy. Cardiology 1991; 78: 161-167
6. Caforio AL, Stewart JT, Bonifacio E, Burke M, Davies MJ, McKenna WJ, Bottazzo GF: Inappropriate major histocompatibility complex expression on cardiac tissue in dilated cardiomyopathy. Relevance for autoimmunity? J Autoimmun 1990; 3: 187-200
7. Koike S: Immunological disorders in patients with dilated cardiomyopathy. With special reference to the production of interleukin-2 and the expression of interleukin-2 receptors in the patients' peripheral blood lymphocytes. Jpn Heart J 1989; 30: 799-807
8. Seko Y. Yamazaki T, Shinkai Y, Yagita H, Okumura K, Naito S, Imataka K, Fujii J, Yazaki Y: Cellular and molecular bases for the immunopathology of the myocardial cell damage involved in acute viral myocarditis with special reference to dilated cardiomyopathy. Jpn Circ J 1992; 56: 1062-1072
9. Toyozaki T, Saito T, Takano H, Yorimitsu K. Kobayashi S, Ichikawa H, Takeda K, Inagaki Y: Expression of intercellular adhesion molecule-1 on cardiac myocytes for myocarditis before and during immunosuppressive therapy. Am J Cardiol 1993; 72: 441-444
10. Das SK, Cassidy JT, Petty RE: Antibodies against heart muscle and nuclear constituents in cardiomyopathy. Am Heart J 1972; 83: 159-166
11. Caforio AL, Grazzini M, Mann JM, Keeling PJ, Bottazzo GF, McKenna WJ, Schiaffino S: Identification of alpha- and beta-cardiac myosin heavy chain isoforms as major autoantigens in dilated cardiomyopathy. Circulation 1992; 85: 1734-1742
12. Caforio AL, Mahon NJ, Mckenna WJ: Cardiac autoantibodies to myosin and other heart-specific autoantigens in myocarditis and dilated cardiomyopathy. Autoimmunity 2001; 34: 199-204
13. Latif N, Baker CS, Dunn MJ. Rose ML, Brady P, Yacoub MH: Frequency and specificity of antiheart antibodies in patients with dilated cardiomyopathy detected using SDS-PAGE and western blotting. J Am Coll Cardiol 1993: 22: 1378-1384
14. Neumann DA, Burek CL, Baughman KL, Rose NR, Herskowitz A: Circulating heart-reactive antibodies in patients with myocarditis or cardiomyopathy. J Am Coll Cardiol 1990; 16: 839-846
15. Schultheiss HP, Schwimmbeck P, Bolte HD, Klingenberg M: The antigenic characteristics and the significance of the adenine nucleotide translocator as a major autoantigen to antimitochondrial antibodies in dilated cardiomyopathy. Adv Myocardiol 1985; 6: 311-327
16. Schulze K. Becker BF, Schauer R, Schultheiss HP: Antibodies to ADP-ATP carrier - an autoantigen in myocarditis and dilated cardiomyopathy - impair cardiac function. Circulation 1990; 81: 959-969
17. Ansari AA, Herskowitz A, Danner DJ: Identification of mitochondrial proteins that serve as targets for autoimmunity in human dilated cardiomyopathy. Circulation 1988; 78 suppl: 457
18. Klein R, Maisch B, Kochsiek K, Berg PA: Demonstration of organ specific antibodies against heart mitochondria (anti-M7) in sera from patients with some forms of heart diseases. Clin Exp Immunol 1984; 58: 283-292
19. Ansari AA. Neckelmann N, Villinger F, Leung P, Danner DJ, Brar SS, Zhao S, Gravanis MB, Mayne A, Gershwin ME, et al: Epitope mapping of the branched chain alpha-ketoacid dehydrogenase dihydrolipoyl transacylase (BCKD-E2) protein that reacts with sera from patients with idiopathic dilated cardiomyopathy. J Immunol 1994; 153: 4754-4765
20. Wolff PG, Kuhl U, Schultheiss HP: Laminin distribution and autoantibodies to laminin in dilated cardiomyopathy and myocarditis. Am Heart J 1989; 117: 1303-1309
21. Sterin-Borda L, Cremaschi G, Pascual J, Genaro A, Borda E: Alloimmune IgG binds and modulates cardiac beta-adrenoceptor activity. Clin Exp Immunol 1984; 58: 223-228
22. Wallukat G, Wollenberger A: Effects of the serum gamma globulin fraction of patients with allergic asthma and dilated cardiomyopathy on chronotropic beta adrenoceptor function in cultured neonatal rat heart myocytes. Biomed Biochim Acta 1987; 46: S634-639
23. Limas CJ, Limas C, Kubo SH, Olivari MT: Anti-β-receptor antibodies in human dilated cardiomyopathy and correlation with HLA-DR antigens. Am J Cardiol 1990; 65: 483-487
24. Magnusson Y, Marullo S, Hoyer S, Waagstein F, Andersson B, Vahlne A, Guillet JG, Strosberg AD, Hjalmarson A, Hoebeke J: Mapping of a functional autoimmune epitope on the β1-adrenergic receptor in patients with idiopathic dilated cardiomyopathy. J Clin Invest 1990; 86: 1658-1663
25. Fu ML, Hoebeke J, Matsui S, Matoba M, Magnusson Y, Hedner T, Herlitz H, Hjalmarson Å: Autoantibodies against cardiac G-protein-coupled receptors define different populations with cardiomyopathies but not with hypertension. Clin Immunol Immunopathol 1994; 72: 15-20
26. Matsui S, Fu ML, Shimizu M, Fukuoka T, Teraoka K, Takekoshi N, Murakami E, Hjalmarson A: Dilated cardiomyopathy defines serum autoantibodies against G-protein-coupled cardiovascular receptors. Autoimmunity 1995; 21: 85-88
27. Fu LX, Magnusson Y, Bergh CH, Liljeqvist JA, Waagstein F, Hjalmarson Å, Hoebeke J: Localization of a functional autoimmune epitope on the muscarinic acetylcholine receptor-2 in patients with idiopathic dilated cardiomyopathy. J Clin Invest 1993; 91: 1964-1968
28. Baba A, Yoshikawa T, Mitamura H, Akaishi M, Ogawa S: Autoantibodies against sarcolemmal Na-K-ATPase in patients with dilated cardiomyopathy: autoimmune basis for ventricular arrhythmias in patients with congestive heart failure: J Cardiol 2002; 39: 50-51 (In Japanese)
29. Mandi Y, Hogye M, Talha EM, Skolak E, Csanady M: Cytokine production and antibodies against heat shock protein 60 in cardiomyopathies of different origins. Pathobiology 2000; 68: 150-158
30. Venter JC, Fraser CM, Harrison LC: Autoantibodies to β2-adrenergic receptors: a possible cause of adrenergic hyporesponsiveness in allergic rhinitis and asthma. Science 1980; 207: 1361-1363
31. Limas CJ, Goldenberg IF, Limas C: Autoantibodies against β-adrenoceptors in human idiopathic dilated cardiomyopathy. Circ Res 1989; 64: 97-103
32. Liu HR, Zhao RR, Zhi JM, Wu BW, Fu ML: Screening of serum autoantibodies to cardiac beta1-adrenoceptors and M2-muscarinic acetylcholine receptors in 408 healthy subjects of varying ages. Autoimmunity 1999; 29: 43-51
33. Jahns R, Boivin V, Siegmund C, Boege F, Lohse MJ, Inselmann G: Activating beta-1-adrenoceptor antibodies are not associated with cardiomyopathies secondary to valvular or hypertensive heart disease. J Am Coll Cardiol 1999; 34: 1545-1551
34. Fu ML, Herlitz H, Wallukat G, Hilme E, Hedner T, Hoebeke J, Hjalmarson Å: Functional autoimmune epitope on alpha 1-adrenergic receptors in patients with malignant hypertension. Lancet 1994; 344: 1660-1663
35. Fu ML, Herlitz H, Schulze W, Wallukat G, Micke P, Eftekhari P, Sjogren KG, Hjalmarson A, Muller-Esterl W, Hoebeke J: Autoantibodies against the angiotensin receptor (AT1) in patients with hypertension. J Hypertens 2000; 18: 945-953
36. Liu HR, Zhao RR, Jiao XY, Wang YY, Fu M: Relationship of myocardial remodeling to the genesis of serum autoantibodies to cardiac beta (1)-adrenoceptors and muscarinic type 2 acetylcholine receptors in rats. J Am Coll Cardiol 2002; 39: 1866-1873
37. Chiale PA, Ferrari I: Autoantibodies in Chagas' cardiomyopathy and arrhythmias. Autoimmunity 2001; 34: 205-210
38. Jahns R, Boivin V, Krapf T, Wallukat G, Boege F, Lohse MJ: Modulation of betal-adrenoceptor activity by domain-specific antibodies and heart failure-associated autoantibodies. J Am Coll Cardiol 2000; 36: 1280-1287
39. Warraich RS, Dunn MJ, Yacoub MH: Subclass specificity of autoantibodies against myosin in patients with idiopathic dilated cardiomyopathy: pro-inflammatory antibodies in DCM patients. Biochem Biophys Res Commun 1999; 259: 255-261
40. Wallukat G, Wollenberger A, Morwinski R, Pitschner HF: Anti-β1-adrenoceptor autoantibodies with chronotropic activity from the serum of patients with dilated cardiomyopathy: mapping of epitopes in the first and second extracellular loops. J Mol Cell Cardiol 1995; 27: 397-406
41. Magnusson Y, Wallukat G, Waagstein F. Hjalmarson Å, Hoebeke J: Autoimmunity in idiopathic dilated cardiomyopathy. Characterization of antibodies against the β1-adrenoceptor with positive chronotropic effect. Circulation 1994; 89: 2760-2767
42. Krause EG, Bartel S, Beyerdorfer I, Wallukat G: Activation of cyclic AMP-dependent protein kinase in cardiomyocytes by antibeta 1-adrenoceptor autoantibodies from patients with idiopathic dilated cardiomyopathy. Blood Press Suppl 1996; 3: 37-40
43. Wallukat G, Reinke P, Dorffel WV, Luther HP, Bestvater K, Felix SB, Baumann G: Removal of autoantibodies in dilated cardiomyopathy by immunoadsorption. Int J Cardiol 1996; 54: 191-195
44. Wallukat G, Nissen E, Morwinski R, Muller J: Autoantibodies against the beta- and muscarinic receptors in cardiomyopathy. Herz 2000; 25: 261-266
45. Rose NR, Bona C: Defining criteria for autoimmune diseases (Witebsky's postulates revisited). Immunol Today 1993; 14: 426-430
46. Schwimmbeck PL, Badorff C, Rohn G, Schulze K, Schultheiss HP: The role of sensitized T-cells in myocarditis and dilated cardiomyopathy. Int J Cardiol 1996; 54: 117-125
47. Omerovic E, Bollano E, Andersson B, Kujacic V, Schulze W, Hjalmarson A, Waagstein F, Fu M: Induction of cardiomyopathy in severe combined immunodeficiency mice by transfer of lymphocytes from patients with idiopathic dilated cardiomyopathy. Autoimmunity 2000; 32: 271-280
48. Matsui S, Fu ML, Katsuda S, Hayase M, Yamaguchi N, Teraoka K, Kurihara T, Takekoshi N, Murakami E, Hoebeke J, Hjalmarson Å: Peptides derived from cardiovascular G-protein-coupled receptors induce morphological cardiomyopathic changes in immunized rabbits. J Mol Cell Cardiol 1997; 29: 641-655
49. Matsui S, Fu ML, Hayase M, Katsuda S, Yamaguchi N, Teraoka K, Kurihara T, Takekoshi N: Beneficial effect of muscarinic-2 antagonist on dilated cardiomyopathy induced by autoimmune mechanism against muscarinic-2 receptor. J Cardiovasc Pharmacol 2001; 38 Suppl 1: 843-49
50. Matsui S, Fu ML, Hayase M, Katsuda S, Yamaguchi N, Teraoka K, Kurihara T, Takekoshi N: Active immunization of combined beta1-adrenoceptor and M2-muscarinic receptor peptides induces cardiac hypertrophy in rabbits. J Card Fail 1999; 5: 246-254
51. Iwata M, Yoshikawa T, Baba A, Anzai T, Nakamura I, Wainai Y, Takahashi T, Ogawa S: Autoimmunity against the second extracellular loop of beta (1)-adrenergic receptors induces beta-adrenergic receptor desensitization and myocardial hypertrophy in vivo. Circ Res 2001; 88: 578-586
52. Matsui S, Persson M, Fu HM, Hayase M, Katsuda S, Teraoka K, Kurihara T, Fu ML: Protective effect of bisoprolol on beta-1 adrenoceptor peptide-induced autoimmune myocardial damage in rabbits. Herz 2000; 25: 267-270
53. Dorffel WV, Felix SB, Wallukat G, Brehme S, Bestvater K, Hofmann T, Kleber FX, Baumann G, Reinke P: Short-term hemodynamic effects of immunoadsorption in dilated cardiomyopathy. Circulation 1997; 95: 1994-1997
54. Muller J, Wallukat G, Dandel M, Bieda H, Brandes K, Spiegelsberger S, Nissen E, Kunze R, Hetzer R: Immunoglobulin adsorption in patients with idiopathic dilated cardiomyopathy. Circulation 2000; 101: 385-391
55. Felix SB, Staudt A, Dorffel WV, Stangl V, Merkel K, Pohl M, Docke WD, Morgera S. Neumayer HH, Wernecke KD, et al: Hemodynamic effects of immunoadsorption and subsequent immunoglobulin substitution in dilated cardiomyopathy: three-month results from a randomized study. J Am Coll Cardiol 2000; 35: 1590-1598
56. Staudt A, Schaper F, Stangl V, Plagemann A, Bohm M, Merkel K, Wallukat G, Wernecke KD, Stangl K, Baumann G, et al: Immunohistological changes in dilated cardiomyopathy induced by immunoadsorption therapy and subsequent immunoglobulin substitution. Circulation 2001; 103: 2681-2686
57. Christ T, Dobrev D, Wallukat G, Schuler S, Ravens U: Acute hemodynamic effects during immunoadsorption in patients with dilated cardiomyopathy positive for beta 1-adrenoceptor autoantibodies. Methods Find Exp Clin Pharmacol 2001; 23: 141-144
58. Wallukat G, Fu HM, Matsui S, Hjalmarson A, Fu ML: Autoantibodies against M2 muscarinic receptors in patients with cardiomyopathy display non-desensitized agonist-like effects. Life Sci 1999; 64: 465-469
59. Felix SB, Staudt A, Landsberger M, Grosse Y, Stangl V, Spielhagen T, Wallukat G, Wernecke KD, Baumann G, Stangl K: Removal of cardiodepressant antibodies in dilated cardiomyopathy by immunoadsorption. J Am Coll Cardiol 2002; 39: 646-652