Children with meningeal signs: Predicting who needs empiric antibiotic treatment

Archives of Pediatrics and Adolescent Medicine

Volumn 156, Issue 12, 2002, Pages 1189-1194

  Oostenbrink, Rianne ^a   Moons, Karel G M ^a   Twijnstra, Minke J ^b   Grobbee, Diederick E ^b   Moll, Henriette A ^a  

^a SOPHIA CHILDREN S HOSPITAL   (Netherlands)

^b UTRECHT UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; GLUCOSE;

ADOLESCENT; ANTIBIOTIC THERAPY; ARTICLE; BACTERIAL MENINGITIS; BACTERIUM CULTURE; BIOLOGICAL MODEL; BLOOD CULTURE; CEREBROSPINAL FLUID CULTURE; CEREBROSPINAL FLUID CYTOLOGY; CHILD; CLINICAL FEATURE; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; INFANT; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; MEDICAL DECISION MAKING; MULTIVARIATE LOGISTIC REGRESSION ANALYSIS; NEUTROPHIL; PREDICTION; PRIORITY JOURNAL; RECEIVER OPERATING CHARACTERISTIC; TREATMENT INDICATION;

EID: 0036951142     PISSN: 10724710     EISSN: None     Source Type: Journal    
DOI: 10.1001/archpedi.156.12.1189     Document Type: Article

References (32)

1. Bryant K, Marshall GS. Most cerebrospinal fluid cultures in children with bacterial meningitis are positive within two days. Pediatr Infect Dis J. 1999;18:732-733.
2. Feigin RD, McCracken GH Jr, Klein JO. Diagnosis and management of meningitis Pediatr Infect Dis J. 1992;11:785-814.
3. Oliver LG, Harwoord-Nuss AL. Bacterial meningitis in infants and children: a review. J Emerg Med. 1993;11:555-564.
4. Barnett ED, Bauchner H, Teele DW, Klein JO. Serious bacterial infections in febrile infants and children selected for lumbar puncture. Pediatr Infect Dis J. 1994;13:950-953.
5. Levy M, Wong E, Fried D. Diseases that mimic meningitis: analysis of 650 lumbar punctures. Clin Pediatr. 1990;29:254-255, 258-261.
6. Oostenbrink R, Theunissen CCW, Moons KGM, Derksen-Lubsen G, Grobbee DE, Moll HA. Signs of meningeal irritation at the emergency department: how often bacterial meningitis? Pediatr Emerg Care. 2001;17:161-164.
7. Hoen B, Viel JF, Paquot C, Gerard A, Canton P. Multivariate approach to differential diagnosis of acute meningitis. Eur J Clin Microbiol Infect Dis. 1995;14: 267-274.
8. Spanos A, Harrell FE Jr, Durack DT. Differential diagnosis of acute meningitis: an analysis of the predictive value of initial observations. JAMA. 1989;262:2700-2707.
9. Rodewald LE, Wocdin KA, Szilagyi PG, Arvan DA, Raubertas RF, Powell KR. Relevance of common tests of cerebrospinal fluid in screening for bacterial meningitis. J Pediatr. 1991;119:363-369.
10. Deivanayagam N, Ashok TP, Nedunchelian K, Ahamed SS, Mala N. Evaluation of CSF variables as a diagnostic test for bacterial meningitis. J Trop Pediatr. 1993; 39:284-287.
11. Freedman SB, Marrocco A, Pirle J, Dick PT. Predictors of bacterial meningitis in the era after Haemophilus influenzae. Arch Pediatr Adolesc Med. 2001;155:1301-1306.
12. Negrini B, Kelleher KJ, Wald ER. Cerebrospinal fluid findings in aseptic versus bacterial meningitis. Pediatrics. 2000;105:316-319.
13. Moons KGM, van Es GA, Michel BW, Büller HR, Habbema JDF, Grobbee DE. Redundancy of single diagnostic test evaluation. Epidemiology. 1999;10:276-281.
14. van der Schouw YT, van Dijk R, Verbeek ALM. Problems in selecting the adequate patient population from existing data files for assessment studies of new diagnostic tests. J Clin Epidemiol. 1995;48:417-422
15. Knottnerus JA, Leffers JP. The influence of referral patterns on the characteristics of diagnostic tests. J Clin Epidemiol. 1992;45:1143-1154.
16. Oostenbrink R, Moons KGM, Donders ART, Grobbee DE, Moll HA. Prediction of bacterial meningitis in children with meningeal signs: reduction of lumbar punctures. Acta Paediatr. 2001;90:611-617.
17. Moll HA, Jongkind CJ, Aarsen RSR, et al. The development and applicability of a problem oriented patient classification system in a pediatric outpatient clinic [abstract]. In: Program and abstracts of the 16th annual meeting of the European Society for Paediatric Infectious Diseases; May 27-29, 1998; Bled, Slovenia.
18. Vincent J, Thomas K, Mathew O. An improved clinical method for detecting meningeal irritation. Arch Dis Child. 1993;68:215-218.
19. Harrell FE Jr, Lee KL, Mark DB. Multivariable prognostic models: issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors. Stat Med. 1996;15:361-387.
20. Hosmer DW, Lemeshow S, eds. Applied Logistic Regression. New York, NY: John Wiley & Sons Inc; 1989.
21. Hanley JA, McNeil BJ. The meaning and use of the area under a receiver operating characteristic (ROC) curve. Radiology. 1982;143:29-36.
22. Hanley JA, McNeil BJ. A method of comparing the areas under receiver operating characteristic curves derived from the same cases. Radiology. 1983;148: 839-843
23. Greenland S, Finkle WB. A critical look at methods for handling missing covariates in epidemiologic regression analyses. Am J Epidemiol. 1995;142:1255-1264
24. Little RA. Regression with missing X's: a review. J Am Stat Assoc. 1992;87: 1227-1237
25. Efron B. Estimating the error rate of a prediction rule: improvement on cross-validation. J Am Stat Assoc. 1983;78:316-331.
26. Carraccio C, Blotny K, Fisher MC. Cerebrospinal fluid analysis in systemically ill children without central nervous system disease. Pediatrics. 1995;96:48-51.
27. Oostenbrink R, Oostenbrink JB, Moons KGM, et al. Cost utility analysis of patient care in children with meningeal signs. Int J Technol Assess Health Care. 2002;18:485-496.
28. Gerdes LU, Jorgensen PE, Nexo E, Wang P. C-reactive protein and bacterial meningitis: a meta-analysis. Scand J Clin Lab Invest 1998;58:383-394.
29. Bonadio WA. The cerebrospinal fluid: physiologic aspects and alterations associated with bacterial meningitis. Pediatr Infect Dis J. 1992;11:423-431.
30. Conyn-van Spaendonck MA, Veldhuijzen IK, Suijkerbuijk AW, Hirasing RA. Significant decline of the number of invasive Haemophilus influenzae infections in the first 4 years after introduction of vaccination against H influenzae type B in children [in Dutch, Eng]ish summary]. Ned Tijdschr Geneeskd. 2000;144:1069-1073.
31. Valmari P, Peltola H, Ruuskanen O, Korvenranta H. Childhood bacterial meningitis: initial symptoms and signs related to age, and reasons for consulting a physician. Eur J Pediatr. 1987;146:515-518.
32. Begg CB. Biases in the assessment of diagnostic tests. Stat Med 1987;6:411-423.