Histone deacetylase inhibitors such as sodium butyrate and trichostatin A inhibit vascular endothelial growth factor (VEGF) secretion from human glioblastoma cells

Brain Tumor Pathology

Volumn 19, Issue 2, 2002, Pages 77-81

  Sawa, Hiroki ^a   Murakami, Hiromi ^a,b   Ohshima, Yuko ^a   Murakami, Masahiro ^b   Yamazaki, Ichiro ^b   Tamura, Yasuo ^b   Mima, Tatsuo ^b   Satone, Akira ^b   Ide, Wataru ^b   Hashimoto, Ikuo ^b   Kamada, Hajime ^b  

^a Hokuto Hospital   (Japan)

^b Hokuto Hospital   (Japan)

Author keywords

Glioma; Histone deacetylase inhibitors; Sodium butyrate; Trichostatin A; VEGF

Indexed keywords

BUTYRIC ACID; HISTONE DEACETYLASE INHIBITOR; ISOPROTEIN; MESSENGER RNA; TRICHOSTATIC ACID; UNCLASSIFIED DRUG; VASCULOTROPIN; VASCULOTROPIN B; VASCULOTROPIN C; VASCULOTROPIN D;

ANGIOGENESIS; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CANCER TISSUE; CELL TYPE; CONTROLLED STUDY; CULTURE MEDIUM; DRUG EFFECT; ENZYME INHIBITION; GENE AMPLIFICATION; GENE EXPRESSION; GLIOBLASTOMA; HUMAN; HUMAN CELL; POLYMERASE CHAIN REACTION; PROTEIN SECRETION;

BLOTTING, WESTERN; BRAIN NEOPLASMS; BUTYRATES; CULTURE MEDIA, CONDITIONED; DEPRESSION, CHEMICAL; ENDOTHELIAL GROWTH FACTORS; ENZYME INHIBITORS; GLIOBLASTOMA; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASES; HISTONE DEACETYLASES; HUMANS; HYDROXAMIC ACIDS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LYMPHOKINES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TUMOR CELLS, CULTURED; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 0036947771     PISSN: 14337398     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02478931     Document Type: Article

References (14)

1. Potorak Z, Cohen T, Sivan R, et al (1997) VEGF 145, a secreted vascular endothelial growth factor isoform that binds to extracellular matrix. J Biol Chem 272:7151-7158
2. Maglione D, Guerriero V, Viglietto G, et al (1991) Isolation of a human placenta cDNA coding for a protein related to the vascular permeability factor. Proc Natl Acad Sci USA 88:9267-9271
3. Olofsson B, Pajusola K, Kaipainen A, et al (1996) Vascular endothelial growth factor B, a novel growth factor for endothelial cells. Proc Natl Acad Sci USA 93:2576-2581
4. Kaipainen A, Korhonen J, Mustonen T, et al (1995) Expression of the fms-like tyrosine kinase 4 gene becomes restricted to lymphatic endothelium during development. Proc Natl Acad Sci USA 92: 3566-3570
5. Achen MG, Jeltsch M, Kukk E, et al (1998) Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinase VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4). Proc Natl Acad Sci USA 95:548-553
6. Ito N, Sawa H, Nagane M, et al (2001) Inhibitory effects of sodium butyrate on proliferation and invasiveness of human glioma cells. Neurosurgery 49:430-437
7. Sawa H, Murakami H, Ohshima Y, et al (2001) Histone deacetylase inhibitors such as sodium butyrate and trichostatin A induce apoptosis through an increase of the bcl-2-related protein Bad. Brain Tumor Pathol 18:109-114
8. Cheng SY, Huang HJ, Nagane M, et al (1996) Suppression of glioblastoma angiogenicity and tumorigenicity by inhibition of endogenous expression of vascular endothelial growth factor. Proc Natl Acad Sci USA 93:8502-8507
9. Yu JL, Rak JW, Klement G, et al (2002) Vascular endothelial growth factor isoform expression as a determinant of blood vessel patterning in human melanoma xenografts. Cancer Res 62:1838-1846
10. Cheng SY, Nagane M, Huang HS, et al (1997) Intracerebral tumor-associated hemorrhage caused by overexpression of the vascular endothelial growth factor isoforms VEGF 121 and VEGF 165 but not VEGF 189. Proc Natl Acad Sci USA 94:12081-12087
11. Malinen T, Jussila L, Veikkola T, et al (2001) Inhibition of lymphangiogenesis with resulting lymphedema in transgenic mice expressing soluble VEGF receptor-3. Nat Med 7:199-205
12. Ueda M, Terai Y, Yamashita Y, et al (2002) Correlation between vascular endothelial growth factor-C expression and invasion phenotype in cervical carcinomas. Int J Cancer 98:335-343
13. Skobe M, Hawighorst T, Jackson DG, et al (2001) Induction of tumor lymphangiogenesis by VEGF-C promotes breast carcinoma metastasis. Nat Med 7:192-198
14. Kim MS, Kwon HJ, Lee YM, et al (2001) Histone deacetylases induce angiogenesis by negative regulation of tumor suppressor genes. Nat Med 7:437-443