Life-threatening thrombocytopenia associated with acute Epstein-Barr virus infection in an older adult

Annals of Hematology

Volumn 81, Issue 11, 2002, Pages 672-675

  Walter, R B ^a,b   Hong, T C ^b   Bachli, E B ^a  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^b Fred Hutchinson Cancer Research Center   (United States)

Author keywords

Acute EBV infection; Infectious mononucleosis; Purpura; Review; Thrombocytopenia

Indexed keywords

ACETYLSALICYLIC ACID; ADENOSINE DIPHOSPHATE; ANTIVIRUS AGENT; CORTICOSTEROID; IMMUNOGLOBULIN; METHYLPREDNISOLONE; NONSTEROID ANTIINFLAMMATORY AGENT; OMEPRAZOLE; RECEPTOR BLOCKING AGENT;

ADULT; ARTICLE; BLEEDING TENDENCY; CASE REPORT; CERVICAL LYMPH NODE; DIFFERENTIAL DIAGNOSIS; DISEASE ASSOCIATION; DISEASE SEVERITY; EPSTEIN BARR VIRUS; HEMATOLOGIC DISEASE; HUMAN; INFECTIOUS MONONUCLEOSIS; LYMPHADENOPATHY; LYMPHOCYTOSIS; MALE; PRIORITY JOURNAL; SEROLOGY; THROMBOCYTE COUNT; THROMBOCYTOPENIA; TREATMENT OUTCOME; VIRUS INFECTION;

ACUTE DISEASE; CRITICAL ILLNESS; DIAGNOSIS, DIFFERENTIAL; EPSTEIN-BARR VIRUS INFECTIONS; HEMORRHAGIC DISORDERS; HUMANS; MALE; MIDDLE AGED; THROMBOCYTOPENIA;

EID: 0036943841     PISSN: 09395555     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00277-002-0557-1     Document Type: Article

References (36)

1. Angle RM, Alt HL (1950) Thrombocytopenic purpura complicating infectious mononucleosis: report of a case and serial platelet counts during the course of infectious mononucleosis. Blood 5:449-457
2. Bernstein A (1940) Infectious mononucleosis. Medicine 19:85-159
3. Bloom GE, Canales L, Fairchild JP (1963) Thrombocytopenia with infectious mononucleosis: two cases in children with review of the literature. Am J Dis Child 106:125-128
4. Cantow EF, Kostinas JE (1966) Studies on infectious mononucleosis: III. Platelets. Am J Med Sci 251:664-667
5. Carter RL (1965) Platelet levels in infectious mononucleosis. Blood 25:817-821
6. Cines DB, Blanchette VS (2002) Immune thrombocytopenic purpura. N Engl J Med 346:995-1008
7. Clancy R, Jenkins E, Firkin B (1971) Platelet defect of infectious mononucleosis. Br Med J 4:646-648
8. Clarke BF, Davies SH (1964) Severe thrombocytopenia in infectious mononucleosis. Am J Med Sci 248:703-708
9. Cohen JI (2000) Epstein-Barr virus infection. N Engl J Med 343:481-492
10. Cottrell JE (1927) Infectious mononucleosis. I. Report of twelve cases. Am J Med Sci 173:472-486
11. Cyran EM, Rowe JM, Bloom RE (1991) Intravenous gammaglobulin treatment for immune thrombocytopenia associated with infectious mononucleosis. Am J Hematol 38:124-129
12. Ellman L, Carvalho A, Jacobson BM, Colman RW (1973) Platelet autoantibody in a case of infectious mononucleosis presenting as thrombocytopenic purpura. Am J Med 55:723-726
13. Ginsburg AD, Ginsburg JC (1982) Infectious mononucleosis in older patients. Can Med Assoc J 127:1103-1104
14. Goldstein E, Porter DY (1969) Fatal thrombocytopenia with cerebral hemorrhage in mononucleosis. Arch Neurol 20:533-535
15. Grossman LA, Wolff SM (1959) Acute thrombocytopenic purpura in infectious mononucleosis. JAMA 171:2208-2210
16. Hugo H, Linde A, Åbom P-E (1989) Epstein-Barr virus induced thrombocytopenia treated with intravenous acyclovir and immunoglobulin. Scand J Infect Dis 21:13-15
17. Kupin WL, Sawdyk M (1986) Anti-HLA antibodies complicating infectious mononucleosis with thrombocytopenia and neutropenia. Henry Ford Hosp Med J 34:65-67
18. Mazza JJ, Magnin GE (1975) Severe thrombocytopenia in infectious mononucleosis: report of two cases and review of the literature. Wis Med J 74:S124-S127
19. Minot GR (1929) A non-fatal case simulating acute leukemia with anemia and thrombocytopenic purpura. Med Clin North Am 13:1-9
20. Ogilvie CM, Parry TE (1952) Infectious mononucleosis with thrombocytopenic purpura. Br Med J 2:977-979
21. Pader E, Grossman H (1956) Thrombocytopenic purpura in infectious mononucleosis. N Y State J Med 56:1905-1910
22. Pipp ML, Means ND, Sixbey JW, Morris KL, Gue CL, Baddour LM (1997) Acute Epstein-Bar virus infection complicated by severe thrombocytopenia. Clin Infect Dis 25:1237-1239
23. Radel EG, Schorr JB (1963) Thrombocytopenic purpura with infectious mononucleosis: report of 2 cases and a review of the literature. J Pediatr 63:46-60
24. Schooley RT (2000) Epstein-Barr virus (infectious mononucleosis). In: Mandell GL, Bennett JE, Dolin R (eds) Mandell, Douglas, and Bennett's principles and practice of infectious diseases. Churchill Livingstone, Philadelphia, pp 1599-1613
25. Schumacher HR (1961) Infectious mononucleosis complicated by chronic thrombocytopenia. JAMA 177:515-516
26. Schumacher HR, Barcay SJ (1962) Hemorrhagic phenomena in infectious mononucleosis. Am J Med Sci 243:175-182
27. Sheehan T, McClymont L, O'Donnell JR (1986) Infectious mononucleosis presenting as thrombocytopenic haemorrhage. Scott Med J 31:116-117
28. Shiver CB Jr, Berg P, Frenkel EP (1956) Palatine petechiae, an early sign in infectious mononucleosis. JAMA 161:592-594
29. Smith EB, Custer RP (1946) Rupture of the spleen in infectious mononucleosis: a clinicopathologic report of seven cases. Blood 1:317-333
30. Sumaya CV, Ench Y (1985) Epstein-Barr virus infectious mononucleosis in children: I. Clinical and general laboratory findings. Pediatrics 75:1003-1010
31. Tager M, Klinghoffer KA (1943) Acute thrombocytopenic purpura hemorrhagica with lymphocytosis; report of a case. Ann Intern Med 18:96-100
32. Tidy HL (1934) Glandular fever and infectious mononucleosis. Lancet 2:180-186
33. Tidy HL (1934) Glandular fever and infectious mononucleosis. Lancet 2:236-240
34. Tidy HL, Morley EB (1921) Glandular fever. Br Med J 1:452-456
35. Wolf PS, Lewinter P (1962) Acute thrombocytopenic purpura infectious mononucleosis. Am Pract 13:270-272
36. Wong SY, Bennett B (1982) Natural history of severe thrombocytopenia in infectious mononucleosis. Postgrad Med J 58:249-251