Induction of epithelial tumors in Drosophila melanogaster heterozygous for the tumor suppressor gene wts

Environmental and Molecular Mutagenesis

Volumn 40, Issue 4, 2002, Pages 277-282

  Eeken, Jan C J ^a,b   Klink, Ilse ^a,b   Van Veen, Bert L ^a,b   Pastink, Albert ^a,b   Ferro, Wouter ^a,b,c  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b JA Cohen Institute Interuniversity Research Institute for Radiopathology and Radiation Protection   (Netherlands)

^c LEIDEN UNIVERSITY   (Netherlands)

Author keywords

Drosophila; Induction of warts epithelial tumors; Loss of heterozygosity; Mutagenicity carcinogenicity test

Indexed keywords

MESYLIC ACID METHYL ESTER;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARCINOGENESIS; CELL CYCLE; CONTROLLED STUDY; DROSOPHILA MELANOGASTER; EPITHELIUM TUMOR; FEMALE; FLY; GENETIC ANALYSIS; HETEROZYGOSITY; HOMOZYGOSITY; LATS1 GENE; MALE; MUTAGEN TESTING; NONHUMAN; PHENOTYPE; SEQUENCE HOMOLOGY; TUMOR SUPPRESSOR GENE; VERRUCA VULGARIS; WTS GENE;

ANIMALS; CELL CYCLE; CROSSES, GENETIC; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; FEMALE; GENETIC MARKERS; HETEROZYGOTE; HOMOZYGOTE; LOSS OF HETEROZYGOSITY; MALE; METHYL METHANESULFONATE; MUTAGENICITY TESTS; MUTAGENS; MUTATION; NEOPLASMS, GLANDULAR AND EPITHELIAL; PHENOTYPE; PHOTORECEPTORS, INVERTEBRATE; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; RECOMBINATION, GENETIC; WARTS; X-RAYS;

DROSOPHILA MELANOGASTER; MAMMALIA; MELANOGASTER;

EID: 0036943008     PISSN: 08936692     EISSN: None     Source Type: Journal    
DOI: 10.1002/em.10119     Document Type: Article

References (11)

1. Becker HJ. 1976. Mitotic recombination. In: Ashburner M, Novitsky E, editors. The genetics and biology of Drosophila, vol. 1c. San Diego: Academic Press.
2. Edgar BA, Lehner CF. 1996. Developmental controls of cell cycle regulators: a fly's perspective. Science 274:1646-1652.
3. Flybase. 1999. The flybase database of the Drosophila genome project and community literature. Nucl Acids Res 27:85-88. http:/flybase. bio.indiana.edu/
4. Justice RW, Zilian O, Woods DF, Bryant PJ. 1995. The Drosophila tumor suppressor gene warts encodes a homolog of the human myotonic dystrophy kinase and is required for the control of cell shape and proliferation. Genes Dev 9:534-546.
5. Lindsley DL, Zimm GG (eds). 1992 The genome of Drosophila melanogaster. San Diego: Academic Press.
6. Potter CJ, Turenschalk GS, Xu T. 2000. Drosophila in cancer research: an expanding role. Trends Genet 16:33-39.
7. St John MA, Tao W, Fei X, Fukumoto R, Carcangiu ML, Brownstein DG, Parlow AF, McGrath J, Xu T. 1999. Mice deficient of Lats1 develop soft-tissue sarcomas, ovarian tumours and pituitary dysfunction. Nat Genet 21:182-186.
8. Tao W, Zhang S, Turenchalk GS, Stewart RA, St John MA, Chen W, Xu T. 1999. Human homologue of the Drosophila melanogaster lats tumour suppressor modulates CDC2 activity. Nat Genet 21:177-181.
9. Xu T, Harrison S. 1994. Mosaic analysis using FLP recombinase. Methods Cell Biol 44:655-682.
10. Xu T, Rubin GM. 1993. Analysis of genetic mosaics in developing and adult Drosophila tissues. Development 117:1223-1237.
11. Xu T, Wang W, Zhang S, Stewart RA, Yu W. 1995. Identifying tumor suppressors in genetic mosaics: the Drosophila lats gene encodes a putative protein kinase. Development 121:1053-1063.