Experimental tinea unguium model to assess topical antifungal agents using the infected human nail with dermatophyte in vitro

Journal of Infection and Chemotherapy

Volumn 8, Issue 4, 2002, Pages 331-335

  Nakashima, Takuji ^a   Nozawa, Akira ^a   Ito, Takao ^a   Majima, Toshiro ^a  

^a POLA CHEMICAL INDUSTRIES INC   (Japan)

Author keywords

Antifungal agent; In vitro; Tinea unguium; Trichophyton mentagrophytes

Indexed keywords

AMOROLFINE; ANTIFUNGAL AGENT; PYRITHIONE SODIUM; TERBINAFINE;

ANTIFUNGAL ACTIVITY; ARTICLE; CONIDIUM; CONTROLLED STUDY; DERMATOPHYTE; DRUG PENETRATION; FUNGUS CULTURE; HUMAN; HUMAN TISSUE; IMAGE ANALYSIS; MYCOSIS; NAIL; ONYCHOMYCOSIS; TRICHOPHYTON MENTAGROPHYTES;

EID: 0036941887     PISSN: 1341321X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10156-002-0192-8     Document Type: Article

References (26)

1. David TR. The clinical efficacy of Terbinafine in the treatment of fungal infection of nail. Rev Contemp Pharmacother 1997;8:299-312.
2. Wu J, Wen H, Liao W. Small-dose itraconazole pulse therapy in the treatment of onychomycosis. Mycoses 1997;40:397-400.
3. Savin RC, Drake L, Babel D, Stewark DM, Rich P, Ling MR, et al. Pharmacokinetics of three once-weekly dosages of fluconazole (150, 300, or 450mg) in distal subungual onychomycosis of the fingernail. J Am Acad Dermatol 1998;38:S110-6.
4. Gupta AK, Katz HI, Shear NH. Drug interactions with itraconazole, fluconazole, and terbinafine and their management. J Am Acad Dermatol 1999;41:237-49.
5. Venkatakrishnan K, von Moltke LL, Greenblatt DJ. Effects of the antifungal agents on oxidative drug metabolism: clinical relevance. Clin Pharmacokin 2000;38:111-80.
6. Joseph WS. Oral treatment options for onychomycosis. J Am Podiatr Med Assoc 1997;87:520-31.
7. Ceschin-Roques CG, Hanel H, Pruja-Bougaret SM, Luc J, Vandermander J, Michel G. Ciclopirox nail lacquer 8%: in vivo penetration into and through nails and in vitro effect on pig skin, Skin Pharmacol 1991;4:89-94.
8. Hay RJ, Roberts DT, Doherty VR, Richardson MD, Midgley G. The topical treatment of onychomycosis using a new combined urea/imidazole preparation. Clin Exp Dermatol 1988;13:164-7.
9. Hay RJ, Mackie RM, Clayton YM. Tioconazole nail solution - an open study of its efficacy in onychomycosis. Clin Exp Dermatol 1985;10:111-5.
10. Reinel D, Clarke C. Comparative efficacy and safety of amorolfine nail lacquer 5% in onychomycosis, once-weekly versus twiceweekly. Clin Exp Dermatol 1992;17:44-9.
11. Uno K, Tuboi R, Ogawa H. Topical treatment of onychomycosis with Bifonazole cream containing 40% urea. Jpn J Med Mycol 1994;35:281-6.
12. Tosti A, Piraccini BM. Treatment of common nail disorders. Dermatol Clin 2000;18:339-48.
13. Weitzman I, Summerbell RC. The dermatophytes. Clin Microbiol Rev 1995;8:240-59.
14. Rashid A, Scott EM, Richardson MD. Inhibitory effect of terbinafine on the invasion of nails by Trichophyton mentagrophytes. J Am Acad Dermatol 1995;33:718-23.
15. Yang D, Chaumont JP, Makki S, Millet-Clerc J. A new simulation model to study the topic penetration of antifungal drugs in hard keratin in vitro. J Mycol Med 1997;7:195-8.
16. Ariga T, Hase T, Yokoo M. Activity of topical antifungals on infected sites - skin permeability and adsorption to horny materials. Nishinihon J Dermatol 1990;52:545-8.
17. Hein LR. Quantitative fractography by digital image processing: NIH Image macro tools for stereo pair analysis and 3-D reconstruction. J Microsc 2001;204:17-28.
18. Zaias N. Onychomycosis. Arch Dermatol 1972;105:263-74.
19. Evans EG. Tinea pedis: clinical experience and efficacy of short treatment. Dermatology (Suppl 1) 1997;194:3-6.
20. Garson JC, Baltenneck F, Leroy F, Riekel C, Muller M. Histological structure of human nail as studied by synchotron X-ray microdiffraction. Cell Mol Biol 2000;46:1025-34.
21. Uchida K, Yamaguchi H. Studies on the affinity of Terbinafine with keratine. Jpn J Med Mycol 1993:34:207-12.
22. Mayer PR, Couch RC, Erickson MK, Wooldridge CB, Brazzell RK. Topical and systemic absorption of sodium pyrithione following topical application to the nails of the rhesus monkey. Skin Pharmacol 1992;5:154-9.
23. Nimura K, Niwano Y, Ishiduka S, Fukumoto R. Comparison of in vitro antifungal activities of topical antimycotics launched in 1990s in Japan. Int J Antimicrob Agents 2001;18:173-8.
24. Elewski BE. Mechanisms of action of systemic antifungal agents. J Am Acad Dermatol 1993;28:S28-34.
25. Polak A. Preclinical data and mode of action of amorolfine. Dermatology (Suppl 1) 1992;184:3-7.
26. Ermolayeva E, Sanders D. Mechanism of pyrithione-induced membrane depolarization in Neurospora crassa. Appl Environ Microbiol 1995;61:3385-90.