Linezolid-A new antibiotic for treatment of MRSA infections in trauma surgery? A reprot of two cases;Linezolid-Ein neues antibiotikum zur behandlung von MRSA-infektionen in der unfallchirurgie? 2 Fallberichte

Unfallchirurg

Volumn 105, Issue 3, 2002, Pages 287-291

  Prokop, Axel ^a   Isenberg, J ^a   Seifert, H ^a   Wenchel, H M ^b   Rehm, K E ^a  

^a UNIVERSITY HOSPITAL OF COLOGNE   (Germany)

^b UNIVERSITY OF COLOGNE   (Germany)

Author keywords

Linezolid; Methicillin resistant Staphylococcus aureus; MRSA; Osteomyelitis; Pneumonia

Indexed keywords

LINEZOLID; RIFAMPICIN; VANCOMYCIN;

ADOLESCENT; AGED; ARTICLE; CASE REPORT; DEBRIDEMENT; FEMALE; HUMAN; HUMERUS FRACTURE; INTENSIVE CARE UNIT; MALE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; OSTEOMYELITIS; OSTEOSYNTHESIS; PNEUMONIA; SKIN INFECTION; SOFT TISSUE INFECTION; STAPHYLOCOCCUS INFECTION; TRAUMATOLOGY;

EID: 0036941834     PISSN: 01775537     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00113-001-0392-1     Document Type: Article

References (18)

1. de Cian W (2000) Clinical efficacy of Linezolid. Linezolid-Profil eines neuen Antibiotikums. Symposium 21. Oktober 2000, Hannover
2. Cammarata SK, Wunderink RG, Timm JA, Hempsall KA, Oliphant TH, Hafkin B (2000) Efficacy of Linezolid in patients with nosocomial pneumonia based on severity of illness determined by baseline APACHE II score. Poster 2234, 40th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) 17.-20. September 2000, Toronto, Kanada
3. Hiramatsu K (1998) The emergence of Staphylococcus aureus with reduced susceptibility to vancomycin in Japan. Am J Med 104: 7-10
4. Hyatt JM, Ballow CH, Forrest A, Turnak MR, Stalker DJ, Schentag JJ (1998) Safety and efficacy of Linezolid (PNU-100766) in eradication of nasal Staphylococcus aureus. Poster A4, 38th Intersience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) 24.-27. September 1998. San Diego, California
5. Kipp F, Peters G, Kühn J (2000) Nosokomiale Infektionen. In: Marre R, Mertens T, Trautmann M, Vanek E (Hrsg) Klinische Infektiologie. Urban & Fischer, München Jena, S 727-743
6. Leach TS, Kaja RW, Eckert S, Schaser R, Todd WM, Hafkin B (2000) Linezolid versus Vancomycin for the treatment of MRSA infections: Results of a randomized phase III trial. Poster, 9th International Congress On Infectious Diseases (ICID) 11. April 2000. Buenos Aires, Argentina
7. Lin AH, Murray RW, Vidmar TJ, Marotti KR (1997) The oxazolidinone eperezolid binds to the 50S ribosomal subunit and competes with binding of chloramphenicol and lincomycin. Antimicrob Agents Chemother 41: 2127-2131
8. Melzer M, Goldsmith D, Gransden W (2000) Successful treatment of vertebral osteomyelitis with Linezolid in a patient receiving hemodialysis and with persistent methicillin-resistant Staphylococcus aureus and Vancomycin-resistant Enterococcus bacteremias. Clin Infect Dis 31: 208-209
9. Panlilio A, Culver DH, Gaynes RP, Bannerjee S, Henderson TS, Tolson TS, Martone WJ (1992) Methicillin-resistant Staphylococcus aureus in U.S. hospitals 1975-1991. Infect Control Hosp Epidemiol 13: 582-586
10. Patel R, Piper KE, Rouse MS, Steckelberg JM (2000) Linezolid therapy of Staphylococcus aureus experimental osteomyelitis. Antimicrob Agents Chemother 44: 3438-3440
11. Peters G, Unertl K (1999) Antibiotikatherapie in der Intensivmedizin. Workshop Potsdam 11. September 1999. Beilage in Chirurg 70
12. Plouffe JF (2000) Emerging therapies for serious gram-positive bacterial infections: a focus on linezolid. Clin Infect Dis 31 (Suppl): 144-149
13. Robert Koch Institut (1998) Erstes Auftreten von MRSA mit verminderter Glykopeptidresistenz in Deutschland nachgewiesen. Epidem Bull RKI 17:123
14. Rubinstein E, Kamarata S, Oliphant TH, Wunderink RG (2001) Linezolid (PNU-100766) versus Vancomycin in the treatment of hospitalised patients with nosocomial pneumonia: A randomised, double-blind multicenter study. Clin Infect Dis 32: 402-412
15. Shinabarger DL, Marotti KR, Murray RW, Lin AH, Melchior EP, Swaney SM (1997) Mechanism of action of oxazolidinones: Effects of Linezolid and Eperezolid on translation reactions. Antimicrob Agents Chemother 41: 2132-2136
16. Swaney SM, Aoki H, Ganoza MC, Shinabarger DL (1998) The oxazolidinone Linezolid inhibits initiation of protein synthesis in bacteria. Antimicrob Agents Chemother 42: 3251-3255
17. Tsiodras S, Gold HS, Sakoulas G et al. (2001) Linezolid resistance in a clinical isolate of Staphylococcus aureus. Lancet 358: 207-208
18. Vincent JL, Bihari DJ, Suter PM et al. (1995) The prevalence of nosocomial infection in intensive care units in Europe (EPIC). Results of the European prevalence of infection in intensive care study. JAMA 274: 639-644