Histogenesis of nonurothelial carcinomas of the urinary bladder from pre-existent transitional cell carcinomas. A histopathological and immunohistochemical study

Urological Research

Volumn 30, Issue 1, 2002, Pages 66-78

  Kunze, E ^a   Francksen, B ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

Cytokeratin 34 E12; Histogenesis; Immunohistochemistry; Metaplasia; Mixed urothelial and nonurothelial carcinomas; MUC5AC apomucin; Phenotypic variants; Pure nonurothelial carcinomas; Transitional cell carcinomas; Urinary bladder

Indexed keywords

APOMUCIN; CYTOKERATIN; MUCIN; UNCLASSIFIED DRUG;

ADENOCARCINOMA; ARTICLE; BLADDER CARCINOMA; CARCINOGENESIS; CELL DIFFERENTIATION; HISTOGENESIS; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; METAPLASIA; PAPILLARY CARCINOMA; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; SQUAMOUS CELL CARCINOMA; TRANSITIONAL CELL CARCINOMA;

CARCINOMA, TRANSITIONAL CELL; GENES, ERBB-2; HUMANS; IMMUNOHISTOCHEMISTRY; MUCINS; PHENOTYPE; PROTO-ONCOGENE PROTEINS C-MYC; RECEPTOR, ERBB-2; URINARY BLADDER NEOPLASMS;

EID: 0036941385     PISSN: 03005623     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00240-001-0232-3     Document Type: Article

References (68)

1. Abdel-Fattah R, Challen C, Griffiths TRL, Robinson MC, Neal DE, Lunec J (1998) Alterations of TP53 in microdissected transitional cell carcinoma of the human urinary bladder: high frequency of TP53 accumulation in the absence of detected mutations is associated with poor prognosis. Br J Cancer 77:2230
2. Ahnen DJ, Brown WR, Kloppel TM (1985) Secretory component: the polymeric immunoglobulin receptor. What's in it for the gastroenterologist and hepatologist? Gastroenterology 89:667
3. Akdas A, Türeri L (1991) The impact of squamous metaplasia in transitional cell carcinoma of the bladder. Int J Urol Nephrol 23:333
4. Bara J, Malarewicz A, Loisillier F, Burtin P (1977) Antigens common to human ovarian mucinous cyst fluid and gastric mucosa. Br J Cancer 36:49
5. Bara J, Gautier R, Daher N, Zaghouani H, Decaens C (1986) Monoclonal antibodies against oncofetal mucin M1 antigens associated with precancerous colonic mucosa. Cancer Res 46:3983
6. Bara J, Gautier R, Mouradian P, Decaens C, Daher N (1991) Oncofetal mucin M1 epitope family: characterization and expression during colonic carcinogenesis. Int J Cancer 47:304
7. Bara J, Decaens C, Loridon-Rosa B, Oriol R (1992) Immunohistological characterization of mucin epitopes by pretreatment of gastro-intestinal sections with periodic acid. J Immunol Methods 149:105
8. Bartek J, Tlaskalova-Hogenova H, Staskova Z, Simeckova J, Vojtesek B, Rejthar A (1989) Secretory component in differentiating normal epithelium, benign lesions and malignancy in the human breast as monitored by monoclonal antibodies. Histochemistry 91:235
9. Bernardi S, Adessi G-L, Billerey C, Chezy E, Carbillet J-P, Bittard H (1999) Immunohistochemical detection of p53 protein overexpression versus gene sequencing in urinary bladder carcinomas. J Urol 162:1496
10. Blomjous CE, Vos W, de Voogt HJ, van der Valk P, Meijer CJ (1989) Small cell carcinoma of the urinary bladder. A clinicopathologic, morphometric, immunohistochemical, and ultrastructural study of 18 cases. Cancer 64:1347
11. Brandtzaeg P (1985) Role of J chain and secretory component in receptor-mediated glandular and hepatic transport of immunoglobulins in man. Scand J Immunol 22:111
12. Brooks JJ, Ernst CS (1984) Immunoreactive secretory component of IgA in human tissues and tumors. Am J Clin Pathol 82:660
13. Burkhard FC, Markwalder R, Thalmann GN, Studer UE (1997) Immunohistochemical determination of p53 overexpression. An easy and readily available method to identify progression in superficial bladder cancer? Urol Res 25 [Suppl]:S31
14. Chodak GW, Straus FW, Schoenberg HW (1981) Simultaneous occurrence of transitional, squamous and adenocarcinoma of the bladder after 15 years of cyclophosphamide ingestion. J Urol 125:424
15. Coombs LM, Oliver S, Sweeney E, Knowles M (1993) Immunocytochemical localization of c-erbB-2 protein in transitional cell carcinoma of the urinary bladder. J Pathol 169:35
16. Cordon-Cardo C, Dalbagni G, Saez GT, Oliva MR, Zhang Z-F, Rosai J, Reuter V, Pellicer A (1994) p53 mutations in human bladder cancer: genotypic versus phenotypic pattern. Int J Cancer 56:347
17. Corica FA, Husman DA, Churchill BM, Young RH, Pacelli A, Lopez-Beltran A, Bostwick DG (1997) Intestinal metaplasia is not a strong risk factor for bladder cancer: study of 53 cases with long-term follow-up. Urology 50:427
18. Daher N, Gonzales J, Gautier R, Bara J (1990) Evidence of mucin M1 antigens in seminal plasma and normal cells of human prostatic urethra in relation to embryonic development and tumors. Prostate 16:57
19. Ding-Wei Y, Jia-fu Z, Song-Xi Q, Yong-Jiang M (1993) Correlation between the expression of oncogenes ras and c-erbB-2 and the biological behavior of bladder tumors. Urol Res 21:39
20. Eimoto H, Tsutsumi M, Nakajima A, Yamamoto K, Takashima Y, Maruyama H, Konishi Y (1988) Expression of the glutathione S-transferase placental form in human lung carcinomas. Carcinogenesis 9:2325
21. Esrig D, Elmajian D, Groshen S, Freeman JA, Stein JP, Chen S-C, Nichols PW, Skinner DG, Jones PA, Cote RJ (1994) Accumulation of nuclear p53 and tumor progression in bladder cancer. N Engl J Med 331:1259
22. Fegen JP, Albert DJ, Persky L (1971) Adenocarcinoma and transitional cell carcinoma occurring simultaneously in the urinary bladder (mixed tumor). J Surg Oncol 3:387
23. Feizi T, Gooi HC, Childs RA, Picard JK, Kemura K, Loomes LM, Thorpe SJ, Housell EF (1984) Tumor-associated and differentiation antigens on the carbohydrate moieties of mucin-type glycoproteins. Biochem Soc Trans 12:591
24. Gardiner RA, Samaratunga ML, Walsh MD, Seymour GJ, Lavin MF (1992) An immunohistological demonstration of c-erbB-2 oncoprotein expression in primary urothelial bladder cancer. Urol Res 20:117
25. Gorgoulis VG, Barbatis C, Poulias I, Karameris AM (1995) Molecular and immunohistochemical evaluation of epidermal growth factor receptor and c-erbB-2 gene product in transitional cell carcinomas of the urinary bladder: a study in Greek patients. Mod Pathol 8:758
26. Gown AM, Vogel AM (1984) Monoclonal antibodies to human intermediate filament proteins. II. Distribution of filament proteins in normal human tissue. Am J Pathol 114:309
27. Gown AM, Vogel AM (1985) Monoclonal antibodies to human intermediate filament protein. III. Analysis of tumors. Am J Clin Pathol 84:413
28. Grace DA, Winter CC (1968) Mixed differentiation of primary carcinoma of the urinary bladder. Cancer 21:1239
29. Grignon DY, Ro JY, Ayala AG, Johnson DE, Ordonez NG (1991) Primary adenocarcinoma of the urinary bladder. A clinicopathologic analysis of 72 cases. Cancer 67:2165
30. Helpap B, Köllermann J (1999) Proliferative pattern of exophytic and superficially invasive and non-invasive low-grade urothelial carcinomas. Hum Pathol 30:145
31. Helpap B, Köllermann J (2000) Assessment of basal cell status and proliferative patterns in flat and papillary urothelial lesions: a contribution to the new WHO classification of urothelial tumors of the urinary bladder. Hum Pathol 31:745
32. Ioachim E, Charchanti A, Stavropoulos NE, Skopelitou A, Athanassiou ED, Agnantis NY (2000) Immunohistochemical expression of retinoblastoma gene product (Rb), p53 protein, MDM2, c-erbB-2, HLA-DR and proliferation indices in human urinary bladder carcinoma. Histol Histopathol 15:721
33. Jacobs LB, Brooks JD, Epstein JI (1997) Differentiation of colonic metaplasia from adenocarcinoma of urinary bladder. Human Pathol 28:1152
34. Kotake T, Saiki S, Kinouchi T, Shiku H, Nakayama E (1990) Detection of the c-myc gene product in urinary bladder cancer. Jpn J Cancer Res 81:1198
35. Kunze E (1998) Formale Pathogenese des Harnblasenkarzinoms. In: Bichler K-H, Wilbert D, Wechsel HW, Strohmaier WL (eds) Diagnostik und Therapie des Harnblasenkarzinoms. Einhorn, Reinbeck, p. 14
36. Kunze E (1998) Histogenesis of nonurothelial carcinomas in the human and rat urinary bladder. Exp Toxicol Pathol 50:341
37. Kunze E, Chowaniec J (1990) Tumours of the urinary bladder. In: Turusov VS, Mohr W (eds) Pathology of Tumours in Laboratory Animals. International Agency for Research on Cancer, Lyon, p. 345
38. Kunze E, Francksen B, Schulz H (2001) Expression of MU-C5AC apomucin in transitional cell carcinomas of the urinary bladder and its possible role in the development of mucus-secreting adenocarcinomas. Virchows Arch 439:609
39. Kvale D, Rognum TO, Brandtzaeg P (1987) Elevated levels of secretory immunoglobulins A and M in serum of patients with large bowel carcinoma indicate liver metastasis. Cancer 59:203
40. Lipponen P (1993) Expression of c-erbB-2 oncoprotein in transitional cell bladder cancer. Eur J Cancer 29:749
41. Lipponen PK (1993) Over-expression of p53 nuclear oncoprotein in transitional-cell bladder cancer and its prognostic value. Int J Cancer 53:365
42. Lipponen PK (1995) Expression of c-myc protein is related to cell proliferation and expression of growth factor receptors in transitional cell bladder cancer. J Pathol 175:203
43. Lipponen P, Eskelinen M, Syrjänen S, Tervahauta A, Syrjänen K (1991) Use of immunohistochemically demonstrated c-erbB-2 oncoprotein expression as a prognostic factor in transitional cell carcinoma of the urinary bladder. Eur Urol 20:238
44. Logothetis CJ, Dexeus FH, Chong C, Sella A, Ayala AG, Ro JY, Pilat S (1989) Cisplatin, cyclophosphamide and doxorubicin chemotherapy for unresectable urothelial tumors: the M.D. Anderson experience. J Urol 141:33
45. Martin JE, Jenkins BJ, Zuk RJ, Blandy JP, Baithun SI (1989) Clinical importance of squamous metaplasia in invasive transitional cell carcinoma of the bladder. J Clin Pathol 42:250
46. Mills SE, Wolfe JT, Weiss MA, Swanson PE, Wick MR, Fowler JE, Young RH (1987) Small cell undifferentiated carcinoma of the urinary bladder. A light-microscopic, immunohistochemical, and ultrastructural study of 12 cases. Am J Surg Pathol 11:606
47. Miyamoto H, Kubota Y, Noguchi S, Takase K, Matsuzaki J, Moriyama M, Takebayashi S, Kitamura H, Hosaka M (2000) c-erbB-2 gene amplification as a prognostic marker in human bladder cancer. Urology 55:679
48. Moll R, Franke WW, Schiller DL (1982) The catalog of human cytokeratins: pattern of expression in normal epithelia, tumors and cultured cells. Cell 31:11
49. Moll R, Achstätter T, Becht E, Balcarova-Ständer J, Ittensohn M, Franke WW (1988) Cytokeratins in normal and malignant transitional epithelium. Am J Pathol 132:123
50. Moll R (1992) Molecular diversity of cytokeratins: significance for cell and tumor differentiation. Acta Histochemica [Suppl XLI]:117
51. Moriyama M, Akiyama T, Yamamoto T, Kawamoto T, Kato T, Sato K, Watanuki T, Hikage T, Katsuta N, Mori S (1991) Expression of c-erbB-2 gene product in urinary bladder cancer. J Urol 145:423
52. Niehaus GA, Kratzke RA, Froberg MK, Aeppli DM, Nguyen PL, Geradts J (1999) G1 checkpoint protein and p53 abnormalities occur in most invasive transitional cell carcinomas of the urinary bladder. Br J Cancer 80:1175
53. O'Brien AM, Urbanski SJ (1985) Papillary adenocarcinoma in situ of bladder. J Urol 134:544
54. Ordonez NG, Khorsand J, Ayala AG, Sneige N (1986) Oat cell carcinoma of the urinary tract. An immunohistochemical and electron microscopic study. Cancer 58:2519
55. Sakamoto N, Tsuneyoshi M, Enjoji M (1992) Urinary bladder carcinoma with a metaplastic squamous component: a mapping of 31 cases. Histopathology 21:135
56. Sarkis AS, Dalbagni G, Cordon-Cardo C, Zhang Z-F, Sheinfeld J, Fair WR, Herr HW, Reuter VE (1993) Nuclear overexpression of p53 protein in transitional cell bladder carcinoma: a marker for disease progression. J Natl Cancer Inst 85:53
57. Sarkis AS, Zhang Z-F, Cordon-Cardo C, Melamed J, Dalbagni G, Sheinfeld J, Fair WR, Herr HW, Reuter VE (1993) p53 nuclear overexpression and disease progression in Ta bladder carcinoma. Int J Oncol 3:355
58. Sato K, Moriyama M, Mori S, Saito M, Watanuki T, Terada K, Okuhara E, Akiyama T, Toyoshima K, Yamamoto T, Kato T (1992) An immunohistologic evaluation of c-erbB-2 gene product in patients with urinary bladder carcinoma. Cancer 70:2493
59. Sauter G, Moch H, Moore D, Carroll P, Kerschmann R, Chew K, Mihatsch MJ, Gudat F, Waldman F (1993) Heterogeneity of c-erbB-2 gene amplification in bladder cancer. Cancer Res 53:2199
60. Sauter G, Carroll P, Moch H, Kallioniemi A, Kerschmann R, Narayan P, Mihatsch MJ, Waldman FM (1995) c-myc copy number gains in bladder cancer detected by fluorescence in situ hybridization. Am J Patol 146:1131
61. Schaafsma HE, Ramaekers FCS, van Muijen GNP, Robben H, Lane EB, Leigh IM, Ooms ECM, Schalken JA, van Moorselaar RJA, Ruiter DJ (1991) Cytokeratin expression patterns in metastatic transitional cell carcinomas of the urinary tract. Am J Pathol 139:1389
62. Schaafsma HE, Ramaekers FCS (1994) Cytokeratin subtyping in normal and neoplastic epithelium: basic principles and diagnostic applications. Pathol Annu 29:21
63. Schulz WA, Jankevicius F, Gerharz C-D, Kushima M, van Roeyen C, Bültel H, Göbell P, Shmitz-Dräger BJ (1998) Predictive value of molecular alterations for the prognosis of urothelial carcinoma. Cancer Detect Prev 22:422
64. Starklint H, Kjaergaard J, Jensen NK (1976) Types of metaplasia in forty urothelial bladder carcinomas. Acta Path Microbiol Scand Sect A 84:137
65. Terrier P, Townsend AJ, Coindre JM, Fricke TJ, Cowan KH (1990) An immunohistochemical study of Pi class glutathione S-transferase expression in normal human tissue. Am J Pathol 137:845
66. Theuring F (1992) Cystitis glandularis vom intestinalen Typ (= intestinale Metaplasie) in der Harnblasenschleimhaut mit funktionell bedeutsamer Pseudotumorbildung. Der Pathologe 13:235
67. Thomas DJ, Robinson MC, Charlton R, Wilkinson S, Shenton BK, Neal DE (1993) p53 expression, ploidy and progression in pT1 transitional cell carcinoma of the bladder. Br J Cancer 73:533
68. Wright C, Mellon K, Neal DE, Johnston P, Corbett IP, Home CHW (1990) Expression of c-erbB-2 protein product in bladder cancer. Br J Cancer 62:764