Effects of tamoxifen administration in rat vaginas: An ultrastructural and light microscopy study

European Journal of Gynaecological Oncology

Volumn 23, Issue 6, 2002, Pages 557-560

  Ketani, M A ^b   Ketani, S ^c   Kaloglu C ^a   Guney B ^c  

^a CUMHURIYET UNIVERSITY   (Turkey)

^b DICLE UNIVERSITY   (Turkey)

^c NONE

Author keywords

Adenosis like lesion; Rat; Tamoxifen; Ultrastructural changes; Vagina

Indexed keywords

TAMOXIFEN;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BASEMENT MEMBRANE; BODY WEIGHT; BREAST CANCER; BREAST TUMOR; CELL JUNCTION; CELL SURFACE; CELL VACUOLE; CONTROLLED STUDY; DRUG EFFECT; FEMALE; GYNECOLOGIC CANCER; HISTOLOGY; MICROSCOPY; NONHUMAN; RAT; TRANSMISSION ELECTRON MICROSCOPY; ULTRASTRUCTURE; VAGINA; VAGINA ADENOSIS; VAGINA EPITHELIUM;

ANIMALS; BIRTH WEIGHT; ESTROGEN ANTAGONISTS; FEMALE; INJECTIONS, SUBCUTANEOUS; MODELS, ANIMAL; PREGNANCY; RATS; RATS, WISTAR; TAMOXIFEN; VAGINA;

EID: 0036940992     PISSN: 03922936     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Furr B. J. A., Jordon V. C.: "The pharmacology and clinical uses of tamoxifen". Pharmacol. Ther., 1984, 25, 127.
2. Pasqualini J. R., Giambiagi N., Sumida C., Nuguyen B. L., Gelly C., Maryrand C., Lecerf F.: "Biological responses of tamoxifen in the fetal and newborn vagina and uterus of guinea-pig and in the R27 mammary cancer cell line". J. Steroid Biochem., 1986, 24, 99.
3. Pasqualini J. R., Nguyen B. L., Sumida C., Giambiagi N., Mayrand C.: "Tamoxifen and progesterone effects in target tissues during the perinatal period". J. Steroid Biochem., 1986, 25 (5b), 853.
4. Cunha G. R., Taguchi D., Namikawa, R.: "Teratogenic effect of clomiphene, tamoxifen, and diethylstilbestrol on the developing human female genital tract". Hum. Pathol., 1987, 18, 1132.
5. Jordon V.C.: "Biochemical pharmacology of antiestrogen action". Pharmac. Rev., 1984, 36, 245.
6. Gottardis M. M., Jordon V. C.: "Biological basis of tamoxifen as a chemopreventative agent". Cancer Detection and Prevention, 1993, 17(1).
7. nd ed., Appleton & Lange (ed.) Prentice-Hall, Norwalk, CT 1994, 140.
8. Tuffery, A. A.: "Laboratory Animals: An Introduction for New Experimenters". Great Britain. 1987, 88.
9. Nguyen B. L., Grambiagi N.: "Estrogen and progesterona receptors in the fetal and newborn vagina of guinea pig: biological, morphological and ultrastructural responses to tamoxifen and estradiol". Endocrinology, 1986, 119, 978.
10. Carthew P., Edwards R. E., Nolan B. M., Martin E. A., Heydon R. T., White I. N., Tucker M. J.: "Tamoxifen induces endometrial and vaginal cancer in rats in absence of endometrial hyperplasia". Carcinogenesis, 2000, 21 (4), 793.
11. Taguchi O., Nizhizuka Y.: "Reproductive tract abnormalities in female mice treted neonatally with tamoxifen". Am. J. Gynecol., 1985, 151 (5), 675.
12. Mc Guire W. L.: "Abnormal reproductive development in rats after neonatally administered antiestrogen (tamoxifen)". Biol. Reprod., 1979, 21, 1087.
13. Iguchi T., Hirokawa M., Takasugi N.: "Occurrence of genital tracct abnormalities and bladder hernia in female mice exposed neonatally to tamoxifen". Toxicology, 1986, 42, 1.
14. Yoshida M., Kudoh K., Katsuda S., Takahashi M., Ando J., Maekawa A.: "Inhibition effects of uterine endometrial carcinogenesis in Donryu rats by tamoxifen". Cancer Lett., 1998, 11, 134 (1), 43.
15. Matsuda A., Higuchi K., Karasawa M., Yoneyama S., Deguchi J., Miyamoto M.: "Fourteen-day oral combination dose toxicity study of CGS 16949 A (aromatase inhibitor) with 5-fluorouracil or tamoxifen in rats". J. Toxicol. Sci., 1997, 22 (1), 1.