Simultaneous splenectomy increases risk for opportunistic pneumonia in patients after liver transplantation

Transplant International

Volumn 15, Issue 5, 2002, Pages 226-232

  Neumann, Ulf P ^a   Langrehr, Jan M ^a   Kaisers, Udo ^a   Lang, Martina ^a   Schmitz, Volker ^a   Neuhaus, Peter ^a  

^a HUMBOLDT UNIVERSITY   (Germany)

Author keywords

Liver transplantation; OKT3; Opportunistic pneumonia; Splenectomy

Indexed keywords

AMPHOTERICIN B; AZATHIOPRINE; COTRIMOXAZOLE; CYCLOSPORIN A; FLUCYTOSINE; INOLIMOMAB; OKT 3; PREDNISOLONE; TACROLIMUS; THYMOCYTE ANTIBODY;

ADOLESCENT; ADULT; AGED; ARTICLE; ASPERGILLUS; CONTROLLED STUDY; CYTOMEGALOVIRUS; EARLY DIAGNOSIS; FEMALE; GRAFT REJECTION; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; INCIDENCE; INFECTION RISK; LEGIONELLA PNEUMOPHILA; LIVER TRANSPLANTATION; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; MORBIDITY; MORTALITY; OPPORTUNISTIC INFECTION; PNEUMOCYSTIS CARINII; PNEUMONIA; POSTOPERATIVE INFECTION; PRIORITY JOURNAL; RISK ASSESSMENT; SPLENECTOMY; TREATMENT OUTCOME;

ADOLESCENT; ADULT; AGED; ANTIFUNGAL AGENTS; ASPERGILLOSIS; CYTOMEGALOVIRUS INFECTIONS; DRUG THERAPY, COMBINATION; FEMALE; GRAFT REJECTION; HUMANS; IMMUNOSUPPRESSIVE AGENTS; LEGIONNAIRES' DISEASE; LIVER TRANSPLANTATION; MALE; MIDDLE AGED; MYCOSES; OPPORTUNISTIC INFECTIONS; PNEUMONIA, PNEUMOCYSTIS; POSTOPERATIVE COMPLICATIONS; RETROSPECTIVE STUDIES; RISK FACTORS; SPLENECTOMY;

EID: 0036937876     PISSN: 09340874     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00147-002-0399-8     Document Type: Article

References (45)

1. Barkholt L, Ericzon BG, Tollemar J, Malmborg AS, Ehrnst A, Wilczek H, Andersson J (1993) Infections in human liver recipients: different patterns early and late after transplantation. Transpl Int 6:77-84
2. Bodey GP, Vartivarian S (1989) Aspergillosis. Eur J Clin Microbiol Infect Dis 8:413-437
3. Bonten MJ, Gaillard CA, Wouters EF, van-Tiel FH, Stobberingh EE, van-derGeest S (1994) Problems in diagnosing nosocomial pneumonia in mechanically ventilated patients: a review. Crit Care Med 22:1683-1691
4. Colombo JL, Sammut PH, Langnas AN, Shaw BW (1992) The spectrum of Pneumocystis carinii infection after liver transplantation in children. Transplantation 54:621-624
5. Colonna JO 2nd, Winston DJ, Brill JE, Goldstein LI, Hoff MP, Hiatt JR, Quinones-Baldrich W, Ramming KP, Busuttil RW (1988) Infectious complications in liver transplantation. Arch Surg 123:360-364
6. Cook DJ, Brun-Buisson C, Guyatt GH, Sibbald WJ (1994) Evaluation of new diagnostic technologies: bronchoalveolar lavage and the diagnosis of ventilator-associated pneumonia. Crit Care Med 22:1314-1322
7. Copeland J, Wieden M, Feinberg W, Salomon N, Hager D, Galgiani J (1981) Legionnaires' disease following cardiac transplantation. Chest 79:669-671
8. Cuervas-Mons V, Julio-Martinez A, Dekker A, Starzl TE, Van-Thiel DH (1986) Adult liver transplantation: an analysis of the early causes of death in 40 consecutive cases. Hepatology 6:495-501
9. Dominguez EA. (1995). Long-term infectious complications of liver transplantation. Semin Liver Dis 15:133-138
10. Edman JC, Kovacs JA, Masur H, Santi DV, Elwood HJ, Sogin ML (1988) Ribosomal RNA sequence shows Pneumocystis carinii to be a member of the fungi. Nature 334:519-522
11. European FK506 Multicentre Liver Study Group (1994) Randomised trial comparing tacrolimus (FK506) and cyclosporin in prevention of liver allograft rejection. Lancet 344:423-428
12. Fielding AK (1994) Prophylaxis against late infection following splenectomy and bone marrow transplant. Blood Rev 8:179-191
13. Grenvik A, Gordon R (1987) Postoperative care and problems in liver transplantation. Transplant Proc 19:26-33
14. Hayes MJ, Torzillo PJ, Sheil AG, McCaughan GW (1994) Pneumocystis carinii pneumonia after liver transplantation in adults. Clin Transplant 8:499-503
15. Heurlin N, Brattstrom C, Lonnqvist B, Westman L, Lidman C, Andersson J (1991) Aetiology of pulmonary diseases in immunocompromised patients. Eur Respir J 4:10-18
16. Hourani JM, Bellamy PE, Tashkin DP, Batra P, Simmons MS (1991) Pulmonary dysfunction in advanced liver disease: frequent occurrence of an abnormal diffusing capacity. Am J Med 90:693-700
17. Jacobs F, Van-de-Stadt J, Bourgeois N, Struelens MJ, De-Prez C, Adler M, Thys JP, Gelin M (1989) Severe infections early after liver transplantation. Transplant Proc 21:2271-2273
18. Knollmann FD, Maurer J, Bechstein WO, Vogl TJ, Neuhaus P, Felix R (2000) Pulmonary disease in liver transplant recipients. Spectrum of CT features. Acta Radiol 41:230-236
19. Kugler JW, Armitage JO, Helms CM, Klassen LW, Goeken NE, Ahmann GB, Gingrich RD, Johnson W, Gilchrist MJ (1983) Nosocomial Legionnaires' disease. Occurrence in recipients of bone marrow transplants. Am J Med 74:281-288
20. Kusne S, Dummer JS, Singh N, Iwatsuki S, Makowka L, Esquivel C, Tzakis AG, Starzl TE, Ho M (1988) Infections after liver transplantation. An analysis of 101 consecutive cases. Medicine 67:132-143
21. Kusne S, Torre-Cisneros J, Manez R, Irish W, Martin M, Fung J, Simmons RL, Starzl TE (1992) Factors associated with invasive lung aspergillosis and the significance of positive Aspergillus culture after liver transplantation. J Infect Dis 166:1379-1383
22. Langrehr JM, Glanemann M, Schneller A, Neumann U, Guckelberger O, Lohmann R, Klupp J, Jonas S, Knoop M, Lobeck H, Schlag H, Keck H, Settmacher U, Bechstein WO, Neuhaus PJ (1998) A randomized trial comparing anti-interleukin-2 receptor antibody and placebo for immunosuppressive therapy after OLT. Transplant Proc 30:1445-1446
23. Marshall W, Foster RS, Winn W (1981) Legionnaires' disease in renal transplant patients. Am J Surg 141:423-429
24. McDade JE, Shepard CC, Fraser DW, Tsai TR, Redus MA, Dowdle WR (1977) Legionnaires' disease: isolation of a bacterium and demonstration of its role in other respiratory disease. N Engl J Med 297:1197-1203
25. Mermel LA, Maki DG (1990) Bacterial pneumonia in solid organ transplantation. Semin Respir Infect 5:10-29
26. Neuhaus P, Bechstein WO, Blumhardt G, Wiens M, Lemmens P, Langrehr JM, Lohmann R, Steffen R, Schlag H, Slama KJ, et al. (1993) Comparison of quadruple immunosuppression after liver transplantation with ATG or IL-2 receptor antibody. Transplantation 55:1320-1327
27. Neuhaus P, Blumhardt G, Bechstein WO, Steffen R, Platz KP, Keck H (1994) Technique and results of biliary reconstruction using side-to-side choledochocholedochostomy in 300 orthotopic liver transplants. Ann Surg 219:426-434
28. Neuhaus P, Blumhardt G, Bechstein WO, Platz KP, Jonas S, Mueller AR, Langrehr JM, Lohmann R, Schattenfroh N, Knoop M, et al. (1995) Comparison of FK506- and cyclosporin-based immunosuppression in primary orthotopic liver transplantation. A single center experience. Transplantation 59:31-40
29. Neuhaus P, Langrehr JM, Williams R, Calne RY, Pichlmayr R, McMaster P (1997) Tacrolimus-based immunosuppression after liver transplantation: a randomised study comparing dual versus triple low-dose oral regimens. Transpl Int 10:253-261
30. Neumann UP, Knoop M, Langrehr JM, Jonas S, Bechstein WO, Lang M, Neuhaus P (1997) Positive donor cytomegalovirus IgG status as a major risk factor for liver allograft recipient infection. Transplant Proc 29:2859-2860
31. Paya CV, Hermans PE, Washington JA, 2nd, Smith TF, Anhalt JP, Wiesner RH, Krom RA (1989) Incidence, distribution, and outcome of episodes of infection in 100 orthotopic liver transplantations. Mayo Clin Proc 64:555-564
32. Paya CV, Wiesner RH, Hermans PE, Larson-Keller JJ, Ilstrup DM, Krom RA, Rettke S, Smith TF (1993) Risk factors for cytomegalovirus and severe bacterial infections following liver transplantation: a prospective multivariate time-dependent analysis. J Hepatol 18:185-195
33. Prodinger WM, Bonatti H, Allerberger F, Wewalka G, Harrison TG, Aichberger C, Dierich MP, Margreiter R, Tiefenbrunner F (1994) Legionella pneumonia in transplant recipients: a cluster of cases of eight years' duration. J Hosp Infect 26:191-202
34. Raakow R, Steffen R, Lefebre B, Bechstein WO, Blumhardt G, Neuhaus P (1990) Selective bowel decontamination effectively prevents gram-negative bacterial infections after liver transplantation. Transplant Proc 22:1556-1557
35. Rubin RH (1988) Infectious disease problems. In: Maddrey WC (ed) Current topics in gastroenterology: transplantation of the liver. Elsevier, New York
36. Saint-Vil D, Luks FI, Lebel P, Brandt ML, Paradis K, Weber A, Guay J, Guttman FM, Bensoussan AL, Laberge JM, et al. (1991) Infectious complications of pediatric liver transplantation. J Pediatr Surg 26:908-913
37. Samimi F, Irish WD, Eghtesad B, Demetris AJ, Starzl TE, Fung JJ (1998) Role of splenectomy in human liver transplantation under modern-day immunosuppression. Dig Dis Sci 43: 1931-1937
38. Sayles PC, Yanez DM, Wassom DL (1993) Plasmodium yoelii: splenectomy alters the antibody responses of infected mice. Exp Parasitol 76:377-384
39. Schmidt CA, Oettle H, Peng R, Neuhaus P, Blumhardt G, Lohmann R, Wilborn F, Osthoff K, Oertel J, Timm H, et al. (1995) Comparison of polymerase chain reaction from plasma and buffy coat with antigen detection and occurrence of immunoglobulin M for the demonstration of cytomegalovirus infection after liver transplantation. Transplantation 59:1133-1138
40. Slakey DP, Johnson CP, Callaluce RD, Browne BJ, Zhu YR, Roza AM, Adams MB (1993) A prospective randomized comparison of quadruple versus triple therapy for first cadaver transplants with immediate function. Transplantation 56:827-831
41. Steffen R, Reinhartz O, Blumhardt G, Bechstein WO, Raakow R, Langrehr JM, Rossaint R, Slama K, Neuhaus P (1994) Bacterial and fungal colonization and infections using oral selective bowel decontamination in orthotopic liver transplantations. Transpl Int 7:101-108
42. Tokunaga Y, Concepcion W, Berquist WE, Cox KL, Wiviott LD, Garcia-Kennedy R, Itasaka H, Nakazato P, Esquivel CO (1992) Graft involvement by Legionella in a liver transplant recipient. Arch Surg 127:475-477
43. Treger TR, Visscher DW, Bartlett MS, Smith JW (1985) Diagnosis of pulmonary infection caused by Aspergillus: usefulness of respiratory cultures. J Infect Dis 152:572-576
44. Winston DJ, Wirin D, Shaked A, Busuttil RW (1995) Randomised comparison of ganciclovir and high-dose acyclovir for long-term cytomegalovirus prophylaxis in liver-transplant recipients. Lancet 346:69-74
45. Yu VL, Muder RR, Poorsattar A (1986) Significance of isolation of Aspergillus from the respiratory tract in diagnosis of invasive pulmonary aspergillosis. Results from a three-year prospective study. Am J Med 81:249-254