Ethical and practical considerations in managing incidental findings in functional magnetic resonance imaging

Brain and Cognition

Volumn 50, Issue 3, 2002, Pages 358-365

  Illes, Judy ^a,b   Desmond, John E ^b   Huang, Lynn F ^b   Raffin, Thomas A ^a   Atlas, Scott W ^b  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b STANFORD UNIVERSITY   (United States)

Author keywords

Ethics; fMRI; Human subjects; Incidental MRI findings; Informed consent; Neural activation; Performance variation

Indexed keywords

ADULT; ARTICLE; CASE REPORT; COGNITION; CONTROLLED STUDY; EXPERT SYSTEM; HEALTH STATUS; HUMAN; LABORATORY DIAGNOSIS; MALE; MEDICAL ETHICS; MEDICAL RESEARCH; MOTOR PERFORMANCE; NUCLEAR MAGNETIC RESONANCE IMAGING; PERFORMANCE; PRIORITY JOURNAL; VOLUNTEER;

BIOMEDICAL AND BEHAVIORAL RESEARCH; HEALTH CARE AND PUBLIC HEALTH;

ADULT; BIOMEDICAL RESEARCH; ETHICS, CLINICAL; ETHICS, RESEARCH; HUMANS; INCIDENTAL FINDINGS; INFORMED CONSENT; INTRACRANIAL ARTERIOVENOUS MALFORMATIONS; MAGNETIC RESONANCE IMAGING; MALE; PRACTICE GUIDELINES;

EID: 0036937308     PISSN: 02782626     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0278-2626(02)00532-8     Document Type: Article

References (21)

1. Autti, T., Raininko, R., Vanhanen, S. L., Kallio, M., & Santavuori, P. (1994). MRI of the normal brain from early childhood to middle age. Appearances on T2 and proton density weighted images and occurrence of incidental high signal foci. Neuroradiology, 36(8), 644-648.
2. Bryan, R. N., Manolio, T. A., & Schertz, L. D. (1994). A method for using MR to evaluate the effects of cardiovascular disease on the brain: The Cardiovascular Health Study. American Journal of Neuroradiology, 15, 1625-1633.
3. Capron, A. M., Faden, R. R., & Beauchamp, T. L. (1987). (Almost) everything you ever wanted to knew about informed consent. Medical Humanities Review, 1(1), 78-82.
4. De Leeuw, F. E., de Groot, J. C., Achten, E., Oudkerk, M., Ramos, L. M., Heijboer, R., Hofman, A., Jolles, J., van Gijn, J., & Breteler, M. (1999). Prevalence of cerebral white matter lesions in elderly people: A population based magnetic resonance imaging study. The Rotterdam Scan Study. Journal of Neurology, Neurosurgery, and Psychiatry, 70(1), 9-14.
5. Ethics and Humanities Subcommittee of the American Academy of Neurology (1998). Ethical issues in clinical research in neurology: Advancing knowledge and protecting human research subjects. Neurology, 50, 592-595.
6. Greene, J. D., Sommerville, R. B., Nystrom, L. E., Darley, J. M., & Cohen, J. D. (2001). An fMRI investigation of emotional engagement in moral judgment. Science, 293, 2105-2108.
7. Havas, T. E., Motbey, J. A., & Gullane, P. J. (1998). Prevalence of incidental abnormalities on computed tomographic scans of the paranasal sinuses. Archives of Otolaryngology-Head & Neck Surgery, 114(8), 856-859.
8. Illes, J., Kim, B. S., Kaplan, R. T., Reiss, A., & Atlas, S. W. (2002). Neurologic findings in healthy children on pediatric fMRI: Incidence and significance. International Society for Magnetic Resonance Imaging, Honolulu, Hawaii, April.
9. Illes, J., Huang, L., Rosen, A., & Atlas, S. W. (in preparation). The Burden of Incidental Findings in Adult Neuroimaging.
10. Iwabuch, Y., Hanamure, Y., Hirota, J., & Ohyama, M. (1997). Clinical significance of asymptomatic sinus abnormalities on magnetic resonance imaging. Archives of Otolaryngology-Head & Neck Surgery, 123, 602-604.
11. Jensen, J. J., & Black, F. T. (2000). The prevalence and significance of incidental paranasal sinus abnormalities on MRI. Rhinology, 38(1), 33-38.
12. Kass, N. E., Sugarman, J., Faden, R., & Schoch-Spana, M. (1996). Trust, the fragile foundation of contemporary biomedical research. Hastings Center Report, 26(5), 25-29.
13. Katzman, G. L., Dagher, A. P., & Patronas, N. J. (1999). Incidental findings on brain magnetic imaging from 1000 asymptomatic volunteers. Journal of the American Medical Association, 282(1), 36-39
14. Kim, B. S., Illes, J., Kaplan, R. T., Reiss, A., & Atlas, S. W. (2002). Neurologic findings in healthy children on pediatric MRI: Incidence and significance. American Journal of Neuroradiology, 23, 1-4.
15. Oberbauer, R. W., Haase, J., & Pucher, R. (1992). Arachnoid cysts in children: A European cooperative study. Child Nervous System, 8(5), 281-286.
16. Patel, K., Chavda, S. V., Violaris, N., & Pahor, A. L. (1996). Incidental paranasal sinus inflammatory changes in a British population. Journal of Laryngology and Otology, 110(7), 649-651.
17. Shen, E. Y., & Huang, F. Y. (1989). Sonographic finding of ventricular asymmetry in neonatal brain. Archives of Disease in Childhood, 64(5), 730-732.
18. Sugarman, J., Kass, N. E., Goodman, S. N., Perentesis, P., Fernandes, P., & Faden, R. R. (1998). What patients say about medical research. IRB, 20(4), 1-7.
19. Van Veen, V., Cohen, J. D., Botvinick, M. M., Stenger, V. A., & Carter, C. S. (2001). Anterior cingulate cortex, conflict monitoring, and levels of processing. Neuroimage, 14(6), 1302-1308.
20. van der Veken, P. J., Clement, P. A., Buisseret, T., Desprechins, B., Kaufman, L., & Derde, M. P. (1990). CT-scan study of the incidence of sinus involvement and nasal anatomic variations in 196 children. Rhinology, 28(3), 177-184.
21. Wester, K. (1999). Peculiarities of intracranial arachnoid cysts: Location, sidedness, and sex distribution in 126 consecutive patients. Neurosurgery, 45(4), 775-779.