Drug-induced metabolic bone disorders

Seminars in Musculoskeletal Radiology

Volumn 6, Issue 4, 2002, Pages 285-297

  Lawson, Jack ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Congenital abnormality; Osteomalacia; Osteoporosis; Periostitis; Proliferative enthesopathy; Rickets

Indexed keywords

ACETAZOLAMIDE; ALCOHOL; ALUMINUM; AMINOPTERIN; ANTICONVULSIVE AGENT; BISPHOSPHONIC ACID DERIVATIVE; CARBAMAZEPINE; COCAINE; COLESTYRAMINE; DEFEROXAMINE; ETRETINATE; FOLIC ACID ANTAGONIST; GLUTETHIMIDE; HYDANTOIN DERIVATIVE; HYPNOTIC SEDATIVE AGENT; IFOSFAMIDE; ISOTRETINOIN; LAXATIVE; MAGNESIUM SULFATE; METHOTREXATE; NARCOTIC AGENT; PHENOBARBITAL; PHENYTOIN; PRIMIDONE; RETINOID DERIVATIVE; RETINOL; RIFAMPICIN; THALIDOMIDE; UNINDEXED DRUG; WARFARIN;

ACNE; ATRESIA; BONE DEMINERALIZATION; BONE DISEASE; BONE RADIOGRAPHY; BRAIN MALFORMATION; CARDIOVASCULAR DISEASE; CEREBELLUM DISEASE; CLEFT PALATE; CONGENITAL DISORDER; CONGENITAL HEART DISEASE; CONGENITAL ICHTHYOSIFORM ERYTHRODERMA; CONGENITAL MALFORMATION; DRUG INDUCED DISEASE; EAR MALFORMATION; ECHOGRAPHY; EMBRYOPATHY; EPILEPSY; FACE DYSMORPHIA; FETUS DISEASE; FOLIC ACID DEFICIENCY; GASTROINTESTINAL DISEASE; GROWTH RETARDATION; HORMONE DEFICIENCY; HUMAN; HYDROCEPHALUS; HYPEREMESIS GRAVIDARUM; HYPERPARATHYROIDISM; HYPOPLASIA; JOINT STIFFNESS; JUVENILE RHEUMATOID ARTHRITIS; LEPROSY; METABOLIC BONE DISEASE; MICROCEPHALY; MICROPHTHALMIA; OSTEOMALACIA; OSTEOPOROSIS; PAGET BONE DISEASE; PARESTHESIA; PES EQUINOVARUS; PHOCOMELIA; REVIEW; RIB MALFORMATION; RICKETS; SIDE EFFECT; SKELETON MALFORMATION; SKIN DISEASE; SYNDACTYLY; TERATOGENESIS; THALASSEMIA; THYMUS DISEASE; TOXEMIA; UROGENITAL TRACT DISEASE; VALGUS KNEE;

EID: 0036936388     PISSN: 10897860     EISSN: 1098898X     Source Type: Journal    
DOI: 10.1055/s-2002-36727     Document Type: Review

References (83)

1. Forfar JO, Nelson MM. Epidemiology of drugs taken by pregnant women: Drugs that may affect the fetus adversely. Clin Pharmacol Ther 1973;14:632-642
2. McBride WG. Thalidomide and congenital abnormalities. Lancet 1961;2:1358
3. McCredie J, McBride WG. Some congenital abnormalities: Possibly due to embryonic peripheral neuropathy. Clin Radiol 1973;24:204-211
4. McCredie J, Willert HG. Longitudinal limb deficiencies and the sclerotomes. An analysis of 378 dysmelic malformations induced by thalidomide. J Bone Joint Surg Br 1999;81:9-23
5. Rocha J. Thalidomide given to women in Brazil. BMJ 1994;308:1061
6. American Academy of Pediatrics Committee on Drugs. Anticonvulsants and pregnancy. Pediatrics 1979;63:331-333
7. Jick SS, Terris BZ. Anticonvulsants and congenital malformations. Pharmacotherapy 1997;17:561-564
8. Canger R, Battino D, Canevini MP, et al. Malformations in offspring of women with epilepsy: A prospective study. Epilepsia 1991;40:1231-1236
9. Waziri M, Ionasescu V, Zellweger H. Teratogenic effect of anticonvulsant drugs. Am J Dis Child 1976;130:1022-1023
10. Wood PB, Young LW. Pseudo-hyperphalangism in fetal dilantin syndrome. Radiology 1979;131:371-372
11. Robinson PB, Harvey W, Belal MS. Inhibition of cartilage growth by the anticonvulsant drugs diphenylhydantoin and sodium valproate. Br J Exp Pathol 1988;69:17-22
12. Lammer EJ, Chen DT. Retinoic acid embryopathy. N Engl J Med 1985;313:837-841
13. Bagheri MM, Burd L, Martsolf JT, Klug MG. Fetal alcohol syndrome: Maternal and neonatal characteristics. J Perinat Med 1998;26:263-269
14. Jones KL, Smith DW, Ulleland CN. Patterns of malformation in offspring of alcoholic mothers. Lancet 1973:1267-1269
15. Maroteaux P, Lavollay B, Bomsell F, et al. Chondrodysplasia punctata and maternal alcohol intoxication. Arch Fr Pediatr 1984;41:547-550
16. Iosub S, Fuchs M, Bingol N, et al. Incidence of major congenital malformations in offsprings of alcoholics and polydrug users. Alcohol 1985;2:521-523
17. Milunsky A, Graef JW, Gaynor MF Jr. Methotrexateinduced congenital malformations. J Pediatr 1968;72:790-795
18. Buckley LM, Bullaboy CA, Leichtman L, Marquez M. Multiple congenital anomalies associated with weekly low-dose methotrexate treatment of the mother. Arthritis Rheum 1997;40:971-973
19. Viscarello RR, Ferguson DD, Nores J, Hobbins JC. Limb-body wall complex associated with cocaine abuse: Further evidence of cocaine's teratogenicity. Obstet Gynecol 1992;80:523-526
20. Hannig VL, Phillips JA III. Maternal cocaine abuse and fetal anomalies: Evidence for teratogenic effects of cocaine. South Med J 1991;84:498-499
21. Fourie DT, Hay IT. Warfarin as a possible teratogen. S Afr Med J 1975;49:2081-2083
22. Lamontagne JM, Leclerc JE, Carrier C, Bureau M. Warfarin embryopathy. J Otolaryngol 1984;13:127-129
23. Hall JG, Pauli RM, Wilson KM. Maternal and fetal sequelae of anticoagulation during pregnancy. Am J Med 1980;68:122-140
24. Sparber M. Diagnostically confusing complications of diphenylhydantoin therapy. Ann Intern Med 1963;59:914-930
25. Leonidas J, Brill PW, Waldman N. Antiepileptic therapy and rickets in children. Radiology 1973;109:409-412
26. Lifschitz F, Maclaren NK. Vitamin D-dependent rickets in institutionalized mentally retarded children receiving longterm anticonvulsant therapy: A survey of 288 patients. J Pediatr 1973;83:612-620
27. Dent CE, Richens A, Rowe DJF, Stamp TCB. Osteomalacia with long-term anticonvulsant therapy in epilepsy. BMJ 1970;4:69-72
28. Tolman KG, Jubiz W, Sannella J, et al. Osteomalacia associated with anticonvulsant drug therapy in mentally retarded children. Pediatrics 1975;56:45-51
29. O'Hare JA, Duggan B, O'Driscoll B, Callaghan N. Biochemical evidence for osteomalacia with carbamazepine therapy. Acta Neurol Scand 1980;62:282-286
30. Stamp TCB. Drug and chemical-induced rickets (and osteomalacia). In: Preger L, ed. Induced Disease: Drug, Irradiation, Occupation. New York: Grune & Stratton; 1980:27-43
31. Addy P. Rickets associated with anticonvulsant therapy in children with tuberous sclerosis. Arch Dis Child 1997;51:972-974
32. Mallette LE. Acetazolamide-accelerated anticonvulsant osteomalacia. Arch Intern Med 1973;137:1013-1017
33. Campbell JE, Tam CS, Sheppard HH. "Brown tumor" of hyperparathyroidism induced with anticonvulsant medication. J Can Assoc Radiol 1977;28:73-76
34. McCrea ES, Rao CV, Diaconis JN. Roengtenographic changes during long-term diphenylhydantoin therapy. South Med J 1980;73:312-317
35. Kattan KR. Calvarial thickening after dilantin medication. AJR Am J Roentgenol 1970;110:102-105
36. Harris M, Goldhaber P. Root abnormalities in epileptics and the inhibition of parathyroid hormone induced bone resorption by diphenylhydantoin in tissue culture. Arch Oral Biol 1974;19:981-984
37. Kattan KR. Thickening of the heel-pad associated with longterm dilantin therapy. AJR Am J Roentgenol 1975;124:52-56
38. De Virgiliis S, Congia M, Frau F, et al. Deferoxamine-induced growth retardation in patients with thalassemia major. J Pediatr 1988;113:666-669
39. Brill PW, Winchester P, Giardina PJ, Cunningham-Rundles S. Deferoxamine-induced bone dysplasia in patients with thalassemia major. AJR Am J Roentgenol 1991;156:561-565
40. Orzincolo C, Scutellari PN, Castaladi G. Growth plate injury of the long bones in treated β-thalassemia. Skeletal Radiol 1992;21:39-44
41. Chan Y, Li C, Chu WC, Cheng JC, Chik KW. Deferoxamine-induced bone dysplasia in the distal femur and patella of pediatric patients and young adults: MR imaging appearance. AJR Am J Roentgenol 2000;175:1561-1566
42. Chan YL, Li CK, Pang LM, Chik KW. Deferoxamineinduced long bone changes in thalassemic patients-radiographic features, prevalence and relations with growth. Clin Radiol 2000;55:610-614
43. Nagant de Deuxchaisnes C, Rombouts-Lindemans C, Huaux JP, et al. Paget's disease of bone. BMJ 1981;283:1054-1055
44. Wood BJ, Robinson GC. Drug induced changes in myositis ossificans progressiva. Pediatr Radiol 1976;5:40-43
45. Gallacher SJ, Boyle IT, Capell HA. Pseudogout associated with the use of cyclical etidronate therapy. Scott Med J 1991;36:49
46. van Dyke JJ, Falkson HC, van der Merve AM, et al. Unexpected toxicity in patients treated with iphosphamide. Cancer Res 1972;32:921-924
47. Sweeney LE, Hypophosphatemic rickets after ifosfamide treatment in children. Clin Radiol 1993;47:345-347
48. Heaf JG, Nielsen LP. Serum aluminium haemodialysed patients: Relation to osteodystrophy, encephalopathy and aluminium hydroxide consumption. Miner Electrolyte Metab 1984;10:345-350
49. Mjoberg B. Aluminium-induced hip fractures: A hypothesis. J Bone Joint Surg Br 1989;71:538
50. Freundlich M, Zilleruelo G, Abitol C, et al. Infant formula as a cause of aluminium toxicity in neonatal uraemia. Lancet 1985;2:527-529
51. Andreoli SP, Smith JA, Bergstein JM. Aluminum bone disease in children: Radiographic features from diagnosis to resolution. Radiology 1985;156:663-667
52. Hernandez RJ, Sedman AB, Smid DM, Goodman WG. Radiographic manifestations of experimental aluminum toxicity in growing bone. Skeletal Radiol 1987;16:209-215
53. Llewellyn CH, Resnik CS, Brower AC. Case report 288. Skeletal Radiol 1984;12:223-226
54. Greenwood RH, Prunty FTG, Silver J. Osteomalacia after prolonged glutethimide administration. BMJ 1973;1:643-645
55. Lamm CI, Norton KI, Murphy RJC, Wilkins IA, Rabinowitz JG. Congenital rickets associated with magnesium sulfate infusion for tocolysis. J Pediatr 1980;113:1078-1082
56. Brodie MJ, Boobis AR, Dollery CT, et al. Rifampicin and vitamin D metabolism. Clin Pharmacol Ther 1980;27:810-814
57. Heaton KW, Lever JV, Barnard D. Osteomalacia associated with cholestyramine therapy for postiliectomy diarrhoea. Gastroenterology 1972;62:642-646
58. Frame B, Guing HL, Frost HM, Reynolds WA. Osteomalacia induced by laxative (phenolphthalein) ingestion. Arch Intern Med 1971;128:794-796
59. Neumann L, Jenson BG. Osteomalacia from aluminium and magnesium antacids. Report of a case of bilateral hip fracture. Acta Orthop Scand 1989;60:361-362
60. Chudley AE, Brown DR, Holzman IR, Sang Oh K. Nutritional rickets in two very low birth weight infants with chronic lung disease. Arch Dis Child 1980;55:687-690
61. Binstadt DH, L'Heureux PR. Rickets as a complication of intravenous hyperalimentation in infants. Pediatr Radiol 1978;7:211-214
62. Gefter WB, Epstein DM, Anday EK, Dalinka MK. Rickets presenting as multiple fractures in premature infants on hyperalimentation. Radiology 1982;142:371-374
63. Sambrook PN, Birmingham J, Kempler S, et al. Corticosteroid effects on proximal bone femur bone loss. J Bone Miner Res 1990;5:1211-1216
64. Gennair C, Citivelli R. Glucocorticoid-induced osteoporosis. Clin Rheum Dis 1986;12:637-654
65. Luengo M, Picado C, Del Rio L, et al. Vertebral fractures in steroid dependent asthma and involutional osteoporosis: A comparative study. Thorax 1991;46:803-806
66. Gluck OS, Murphy WA, Hahn TJ, Hahn BH. Bone loss in adults receiving alternate day glucocorticoid therapy: A comparison with daily therapy. Arthritis Rheum 1981;24:892-898
67. Murray RO. Radiological bone changes in Cushing's syndrome and steroid therapy. Br J Radiol 1960;33:1-19
68. Maldague BE, Noel HM, Malghem J. The intravertebral vacuum cleft: A sign of ischaemic vertebral collapse. Radiology 1978;129:23-29
69. Ragab AH, Frech RS, Vietti TJ. Osteoporotic fractures secondary to methotrexate therapy of acute leukemia in remission. Cancer 1970;25:580-585
70. Jaffe MD, Willis PW. Multiple fractures associated with long-term sodium heparin therapy. JAMA 1965;193:152-154
71. Caffey J. Chronic poisoning due to excess of vitamin A. AJR Am J Roentgenol 1951;65:12-26
72. Pittsley RA, Yoder FW. Retinoid hyperostosis: Skeletal toxicity associated with long-term administration of 13-cis-retinoic acid for refractory ichthyosis. N Engl J Med 1983;308:1012-1014
73. Lawson JP, McGuire J. The spectrum of skeletal changes associated with long-term administration of 13-cis-retinoic acid. Skeletal Radiol 1987;16:91-97
74. Di Giovanna JJ, Helffgott RK, Gerber LH, Peck GL. Extraspinal tendon and ligament calcification associated with long-term therapy with etretinate. N Engl J Med 1986;315:1177-1182
75. Vilon P, Fiche M, Maugars Y, et al. Sarcome Parosteal du radius apparu lors d'un traitement par etretinate. Rev Rhum 1991;58:825-827
76. Elliott RB, Starling MB, Neutze JM. Medical manipulation of the ductus arterlosus. Lancet 1975;1:140-142
77. Ueda K, Saito A, Nakano H, et al. Cortical hyperostosis following long-term administration of prostaglandin E1 in infants with cyanotic congential heart disease. J Pediatr 1980;97:834-836
78. Hoevels-Guerich H, Haferkorn L, Persigehl M. Widening of cranial sutures after long-term prostaglandin E2 infusion in two newborn infants. J Pediatr 1984;105:72-74
79. Teotia SP, Teotia M. Secondary hyperparathyroidism in patients with endemic fluorosis. BMJ 1973;1:637-640
80. Schulz EE, Engstrom H, Sauser DD, Baylink DJ, Osteoporosis: Radiographic detection of fluoride-induced extraaxial bone formation. Radiology 1986;159:457-462
81. Gerster JC, Charhon SA, Jaeger P, et al. Bilateral fractures of the femoral neck in patients with moderate renal failure receiving fluoride for spinal osteoporosis. BMJ 1983;287:723-725
82. Pak CY. Fluoride and osteoporosis. Proc Soc Exp Biol Med 1989;191:278-286
83. Bregeon Ch, Bernat M, Renier J-C, Rebel A, Basile M. Osteose fluoree après 11 ans de traitement ininteruptee par l'acide niflumique. Nouv Presse Med 1980;9:1446-1447