The spatial patterns of prion protein deposits in cases of variant Creutzfeldt-Jakob disease

Acta Neuropathologica

Volumn 104, Issue 6, 2002, Pages 665-669

  Armstrong, R A ^a   Cairns, N J ^b   Ironside, J W ^c   Lantos, P L ^b  

^a ASTON UNIVERSITY   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c WESTERN GENERAL HOSPITAL   (United Kingdom)

Author keywords

Cerebral cortex; Clustering; Florid deposits; Non florid deposits; Variant Creutzfeldt Jacob disease

Indexed keywords

PRION PROTEIN;

ADULT; ARTICLE; BRAIN CORTEX; CEREBELLUM; CLINICAL ARTICLE; CONTROLLED STUDY; CREUTZFELDT JAKOB DISEASE; DENTATE GYRUS; FEMALE; HIPPOCAMPUS; HUMAN; IMMUNOHISTOCHEMISTRY; MALE; NERVE DEGENERATION; NEUROPATHOLOGY; PRIORITY JOURNAL; PROTEIN LOCALIZATION;

EID: 0036934863     PISSN: 00016322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00401-002-0598-5     Document Type: Article

References (19)

1. Armstrong RA (1993) The usefulness of spatial pattern analysis in understanding the pathogenesis of neurodegenerative disorders, with special reference to plaque formation in Alzheimer's disease. Neurodegeneration 2:73-80
2. Armstrong RA (1997) Analysis of spatial patterns in histological sections of brain tissue. J Neurosci Methods 73:141-147
3. Armstrong RA (1998) β-Amyloid plaques: stages in life history or independent origin? Dement Geriatr Cogn Disord 9:227-238
4. Armstrong RA, Cairns NJ, Lantos PL (2000) The spatial pattern of the vacuolation in patients with sporadic Creutzfeldt-Jakob disease. Neurosci Lett 281:187-190
5. Armstrong RA, Cairns NJ, Lantos PL (2001) The spatial patterns of prion protein deposits in Creutzfeldt-Jakob disease: comparison with β-amyloid deposits in Alzheimer's disease. Neurosci Lett 298:53-56
6. Beekes M, McBride PA (2000) Early accumulation of pathological prion protein in the enteric nervous system and gut-associated lymphoid tissue of hamsters orally infected with scrapie. Neurosci Lett 278:181-184
7. Beekes M, McBride, PA, Baldauf E (1998) Cerebral targeting indicates vagal spread of infection in hamsters fed with scrapie. J Gen Virol 79:601-607
8. Bell JE, Ironside JW (1993) Neuropathology of spongiform encephalopathies in humans. Br Med Bull 49:738-777
9. Cervenakova L, Goldfarb LG, Garruto R, Lee HS, Gajdusek DC, Brown P (1998) Phenotype-genotype studies in kuru: implications for new variant Creutzfeldt-Jakob disease. Proc Natl Acad Sci USA 95:13239-13241
10. Grigoriev V, Escarg-Haye F, Streichenberger N, Kopp N, Langeveld J, Brown, Fournier JG (1999) Submicroscopic immunodetection of PrP in the brain of a patient with new variant Creutzfeldt-Jakob disease. Neurosci Lett 264:57-60
11. Hill AF, Butterworth RJ, Joiner S, Jackson G, Rossor MN, Thomas DJ, Frosh, A, Tolley N, Bell JE, Spencer M, King A, Al-Sarraj S, Ironside JW, Lantos PL, Collinge J (1999) Investigation of variant Creutzfeldt-Jakob disease and other human prion disease with tonsil biopsy samples. Lancet 353:183-189
12. Hiorns RW, Neal JW, Pearson RCA, Powell TPS (1991) Clustering of ipsilateral cortico-cortical projection neurons to area 7 in the rhesus monkey. Proc R Soc London 246:1-9
13. Ironside JW (2000) Pathology of variant Creutzfeldt-Jakob disease. Arch Virol Suppl 16:143-151
14. Ironside JW, Head MW, Bell JE, McCardle L, Will RG (2000) Laboratory diagnosis of variant Creutzfeldt-Jakob disease. Histopathology 37:1-9
15. Krasemann S, Groschup MH, Harmeyer S, Hunsmann G, Bodemer W (1996) Generation of monoclonal antibodies against human prion proteins in PrPO/O mice. Mol Med 2: 725-734
16. Liberski PP, Ironside JW, McCardle L, Shering A (2000) Ultrastructure analysis of the florid plaque in variant Creutzfeldt-Jakob disease. Folia Neuropathol 38:167-170
17. Will R, Ironside JW, Zeidler M, Cousens SN, Estebeiro K, Alperovitch A, Poser S, Pocchiari M, Hofman A, Smith PG (1996) A new variant of Creutzfeldt-Jakob disease in the United Kingdom. Lancet 347:921-925
18. Will RG, Zeidler M, Stewart GE, Macleod MA, Ironside JW, Cousins SN, MacKenzie J, Estibeiro K, Green AJE, Knight RG (2000) Diagnosis of new variant Creutzfeldt-Jakob disease. Ann Neurol 47:575-582
19. Zeidler M, Johnstone EC, Bamber RWK, Dickens CM, Fisher CJ, Francis AF, Goldbaeck R, Higgo R, Johnston-Sabine EC, Lodge GJ, McGarry P, Mitchell S, Tario L, Turner M, Ryley P, Will RG (1997) New variant Creutzfeldt-Jakob disease: psychiatric features. Lancet 350:908-910