Enhanced relaxation of diabetic rabbit cavernosal smooth muscle in response to nitric oxide: Potential relevance to erectile dysfunction

International Journal of Impotence Research

Volumn 14, Issue 6, 2002, Pages 523-532

  Sullivan, M E ^a,b   Mumtaz, F H ^a   Dashwood, M R ^a   Thompson, C S ^a   Naseem, K M ^a   Bruckdorfer, K R ^a   Mikhailidis, D P ^a   Morgan, R J ^a  

^a ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^b CHURCHILL HOSPITAL   (United Kingdom)

Author keywords

Diabetes mellitus; Erectile dysfunction; Nitric oxide

Indexed keywords

N(G) NITROARGININE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE DEHYDROGENASE;

ALLOXAN DIABETES MELLITUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING SITE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORPUS CAVERNOSUM; DIABETES MELLITUS; ENDOTHELIUM; ENZYME ACTIVITY; ERECTILE DYSFUNCTION; HISTOCHEMISTRY; MALE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RABBIT; SMOOTH MUSCLE RELAXATION;

ACETYLCHOLINE; ADRENERGIC ALPHA-AGONISTS; ANIMALS; AUTORADIOGRAPHY; BINDING SITES; BLOOD GLUCOSE; BODY WEIGHT; CHOLESTEROL; DIABETES MELLITUS, EXPERIMENTAL; ELECTRIC STIMULATION; HISTOCYTOCHEMISTRY; IMPOTENCE; MALE; MUSCLE CONTRACTION; MUSCLE RELAXATION; MUSCLE, SMOOTH; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PENIS; PHENYLEPHRINE; RABBITS; VASODILATOR AGENTS;

EID: 0036933868     PISSN: 09559930     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.ijir.3900935     Document Type: Article

References (24)

1. G-nitroarginine inhibits non-adrenergic, non-cholinergic relaxation of human isolated corpus cavernosum. Acta Physiol Scand 1991; 141: 441-442.
2. Ignarro LJ et al. Nitric oxide and cyclic GMP formation upon electrical field stimulation cause relaxation of corpus cavernosum smooth muscle. Biochem Biophys Res Commun 1990; 170: 843-850.
3. G-nitro-L-arginine on the erectile response to cavernous nerve stimulation in the rabbit. Acta Physiol Scand 1991; 143: 299-304.
4. Carrier S et al. Regeneration of nitric oxide synthase-containing nerves after cavernous nerve neurotomy in the rat. J Urol 1995; 153: 1722-1727.
5. McCulloch DK et al. The prevalence of diabetic impotence. Diabetologia 1980; 18: 279-283.
6. Saenz de Tejada I et al. Impaired neurogenic and endothelium-mediated relaxation of penile smooth muscle from diabetic men with impotence. New Engl J Med 1989; 320: 1025-1030.
7. Azadzoi KM, Saenz de Tejada I. Diabetes mellitus impairs neurogenic and endothelium-mediated relaxation of rabbit corpus cavernosum smooth muscle. J Urol 1992; 148: 1587-1591.
8. Pickard RS, Powell PH, Zar MA. The effect of inhibitors of nitric oxide biosynthesis and cyclic GMP formation on nerve-evoked relaxation of human cavernosal smooth muscle. Br J Pharmacol 1991; 104: 755-759.
9. Sullivan ME et al. Autoradiographic localisation of nitric oxide synthase binding sites in normal and diabetic rat corpus cavernosum. Eur Urol 1996; 30: 506-511.
10. G-nitro-arginine in rat brain. Br J Pharmacol 1993; 109: 287-288.
11. G-Nitro-arginine binding in rat brain. Neuropharmacology 1995; 34: 63-73.
12. Dawson TM et al. Nitric oxide synthase and neuronal NADPH diaphorase are identical in brain and peripheral tissues. Proc Natl Acad Sci USA 1991; 88: 7797-7800.
13. Naseem KM et al. Relaxation of rabbit lower urinary tract smooth muscle by nitric oxide and carbon monoxide: modulation by hydrogen peroxide. Eur J Pharmacol 2000; 387: 329-335.
14. Pieper GM, Dondlinger LA. Plasma and vascular tissue arginine are decreased in diabetes: acute arginine supplementation restores endothelium-dependent relaxation by augmenting cGMP production. J Pharmacol Exp Ther 1997; 283: 684-691.
15. Zorgniotti AW, Lizza EF. Effect of large doses of the nitric oxide precursor, L-arginine, on erectile dysfunction. Int J Impot Res 1994; 6: 33-35.
16. Moody JA et al. Effect of long-term oral administration of L-arginine on the rat erectile response. J Urol 1997; 158: 942-947.
17. Bucala R, Tracey KJ, Cerami A. Advanced glycosylation products quench nitric oxide and mediate defective endothelium-dependent vasodilatation in experimental diabetes. J Clin Invest 1991; 87: 432-438.
18. Hoffmann D, Seftel AD, Hampel N, Resnick MI. Advanced glycation end-products quench cavernosal nitric oxide. J Urol 1995; 153: 441A.
19. Westfall DP, Lee TJ-F, Stitzel RE. Morphological and biochemical changes in supersensitive smooth muscle. Fed Proc 1975; 34: 1985-1989.
20. Padma-Nathan H, Goldstein I, Payton T, Krane RJ. Intracavernosal pharmacotherapy: the pharmacologic erection program. World J Urol 1987; 5: 160-165.
21. Garban H et al. Cloning of rat and human inducible penile nitric oxide synthase: application for gene therapy of erectile dysfunction. Biol Reprod 1997; 56: 954-963.
22. Seftel AD et al. Advanced glycation end products in human penis: elevation in diabetic tissue, site of deposition, and possible effect through iNOS or eNOS. Urology 1997; 50: 1016-1026.
23. Kim JH et al. Experimental hypercholesterolemia in rabbits induces cavernosal atherosclerosis with endothelial and smooth muscle cell dysfunction. J Urol 1994; 151: 198-205.
24. Sullivan ME et al. Alterations in endothelin B receptor sites in cavernosal tissue of diabetic rabbits: potential relevance to the pathogenesis of diabetic erectile dysfunction. J Urol 1997; 158: 1966-1972.