Combinatorial solid phase synthesis of multiply substituted 1,4-benzodiazepines and affinity studies on the CCK2 receptor (Part 1)

Drug Design and Discovery

Volumn 18, Issue 1, 2002, Pages 9-21

  Lattmann, Eric ^a   Billington, David C ^a   Poyner, David R ^a   Arayarat, Pornthip ^a   Howitt, Stephen B ^a   Lawrence, Spencer ^a   Offel, Michael ^a  

^a ASTON UNIVERSITY   (United Kingdom)

Author keywords

1,4 Benzodiazepine template; CCK antagonists; Cholecystokinin; Combinatorial chemistry; Lead structure; Receptor binding; Solid phase synthesis; Syn phase crowns

Indexed keywords

1 (2,3 DIHYDRO 1 METHYL 2 OXO 5 PHENYL 1H 1,4 BENZODIAZEPIN 3 YL) 3 (3 METHYLPHENYL)UREA; 2 ISOBUTYL 2,4 DIHYDROFLUORENO[1,9 EF][1,4]DIAZEPIN 2 ONE; 3 BENZYL 7 CHLORO 5 PHENYL 1,3 DIHYDROBENZO[E][1,4]DIAZEPIN 2 ONE; 3 BUTYL 7 CHLORO 5 PHENYL 1,3 DIHYDROBENZO[E][1,4]DIAZEPIN 2 ONE; 3 ISOBUTYL 5 (2 CARBOXYPHENYL) 1,3 DIHYDROBENZO[E][1,4]DIAZEPIN 2 ONE; 3 ISOBUTYL 5 CYCLOHEXYL 1,3 DIHYDROBENZO[E][1,4]DIAZEPIN 2 ONE; 3 ISOBUTYL 5 METHYL 1,3 DIHYDROBENZO[E][1,4]DIAZEPIN 2 ONE; 3 ISOBUTYL 5 PHENYL 1,3 DIHYDROBENZO[E][1,4]DIAZEPIN 2 ONE; 3 ISOBUTYL 7 NITRO 5 PHENYL 1,3 DIHYDROBENZO[E][1,4]DIAZEPIN 2 ONE; 3 ISOBUTYL 7,8 DIMETHOXY 5 METHYL 1,3 DIHYDROBENZO[E][1,4]DIAZEPIN 2 ONE; 3 ISOBUTYL 7,8 METHYLENEDIOXY 5 METHYL 1,3 DIHYDROBENZO[E][1,4]DIAZEPIN 2 ONE; 3 ISOBUTYL 8 METHYL 5 PHENYL 1,3 DIHYDROBENZO[E][1,4]DIAZEPIN 2 ONE; 5 PHENYL 3 PROPYL 1,4 BENZODIAZEPIN 2 ONE; 7 CHLORO 3 (1H INDOL 3 YLMETHYL) 5 PHENYL 1,3 DIHYDRO BENZO[E][1,4]DIAZEPIN 2 ONE; 7 CHLORO 3 (2 METHYLSULFANYLETHYL) 5 PHENYL 1,3 DIHYDROBENZO[E][1,4]DIAZEPIN 2 ONE; 7 CHLORO 3 (4 HYDROXYBENZYL) 5 PHENYL 1,3 DIHYDROBENZO[E][1,4]DIAZEPIN 2 ONE; 7 CHLORO 3 ETHYL 5 PHENYL 1,3 DIHYDROBENZO[E][1,4]DIAZEPIN 2 ONE; 7 CHLORO 3 HEXYL 5 PHENYL 1,3 DIHYDROBENZO[E][1,4]DIAZEPIN 2 ONE; 7 CHLORO 3 ISOBUTYL 5 PHENYL 1,3 DIHYDROBENZO[E][1,4]DIAZEPIN 2 ONE; 7 CHLORO 3 ISOPROPYL 5 PHENYL 1,3 DIHYDROBENZO[E][1,4]DIAZEPIN 2 ONE; 7 CHLORO 3 METHYL 5 PHENYL 1,3 DIHYDROBENZO[E][1,4]DIAZEPIN 2 ONE; 7 CHLORO 3 SEC BUTYL 5 PHENYL 1,3 DIHYDROBENZO[E][1,4]DIAZEPIN 2 ONE; 7 CHLORO 5 (2 CHLOROPHENYL) 3 ISOBUTYL 1,3 DIHYDROBENZO[E][1,4]DIAZEPIN 2 ONE; 7 CHLORO 5 (2 FLUOROPHENYL) 3 ISOBUTYL 1,3 DIHYDROBENZO[E][1,4]DIAZEPIN 2 ONE; 7 CHLORO 5 PHENYL 1,3 DIHYDROBENZO[E][1,4]DIAZEPIN 2 ONE; 7 CHLORO 5 PHENYL 3 PROPYL 1,3 DIHYDROBENZO[E][1,4]DIAZEPIN 2 ONE; 7 CHLORO ETHYLOXYCARBONYLMETHYL 5 PHENYL 1,3 DIHYDROBENZO[E][1,4]DIAZEPIN 2 ONE; BENZODIAZEPINE DERIVATIVE; CHOLECYSTOKININ B RECEPTOR; DEVAZEPIDE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ALKYLATION; ARTICLE; BINDING ASSAY; COMBINATORIAL CHEMISTRY; COMBINATORIAL LIBRARY; DRUG ISOLATION; DRUG PURIFICATION; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; IC 50; INFRARED SPECTROSCOPY; LIPOPHILICITY; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; REACTION OPTIMIZATION; RECEPTOR AFFINITY; SOLID; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION; THIN LAYER CHROMATOGRAPHY;

ANIMALS; BENZODIAZEPINES; BRAIN; COMBINATORIAL CHEMISTRY TECHNIQUES; GUINEA PIGS; MALE; RECEPTOR, CHOLECYSTOKININ B; RECEPTORS, CHOLECYSTOKININ;

EID: 0036933446     PISSN: 10559612     EISSN: None     Source Type: Journal    
DOI: 10.1080/10559610213504     Document Type: Article

References (3)

1. Merrifield.
2. Saita et al. (1991).
3. Charpentier et al. (1988).