Aminoglycosides for intra-abdominal infection: Equal to the challenge?

Surgical Infections

Volumn 3, Issue 4, 2002, Pages 315-333

  Bailey, Jeffrey A ^a   Virgo, Katherine S ^a   Dipiro, Joseph T ^b   Nathens, Avery B ^c   Sawyer, Robert G ^d   Mazuski, John E ^a  

^a SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MEDICAL COLLEGE OF GEORGIA   (United States)

^c UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMIKACIN; AMINOGLYCOSIDE DERIVATIVE; AMPICILLIN; ANTIBIOTIC AGENT; ANTIINFECTIVE AGENT; AZTREONAM; BETA LACTAMASE INHIBITOR; CARBAPENEM DERIVATIVE; CEFALOTIN; CEFAMANDOLE; CEFMINOX; CEFOPERAZONE; CEFOTAXIME; CEFOTETAN; CEFOXITIN; CEFTAZIDIME; CEFTRIAXONE; CEPHALOSPORIN DERIVATIVE; CILASTATIN; CLINDAMYCIN; GENTAMICIN; LATAMOXEF; METRONIDAZOLE; NETILMICIN; PEFLOXACIN; PENICILLIN G; SULBACTAM; TICARCILLIN; TOBRAMYCIN; UNINDEXED DRUG;

ABDOMINAL INFECTION; ARTICLE; CALCULATION; CHI SQUARE TEST; CLINICAL TRIAL; DEMOGRAPHY; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG MONITORING; DRUG SCREENING; FEMALE; HUMAN; MALE; META ANALYSIS; NEPHROTOXICITY; OTOTOXICITY; PRIORITY JOURNAL; RISK ASSESSMENT; SCORING SYSTEM; TREATMENT FAILURE;

EID: 0036932528     PISSN: 10962964     EISSN: None     Source Type: Journal    
DOI: 10.1089/109629602762539544     Document Type: Article

References (128)

1. Bohnen JMA, Solomkin JS, Dellinger EP, et al. Guidelines for clinical care: Anti-infective agents for intra-abdominal infection. A Surgical Infection Society policy statement. Arch Surg 1992;127:83-89.
2. Glass GV. Primary, secondary and meta-analysis of research. Educ Res November 1976;5:3-8.
3. DerSimonian R, Laird N. Meta-analysis in clinical trials. Cont Clin Trials September 1986;7:177-188.
4. L'Abbe KA, Detsky AS, O'Rourke K. Meta-analysis in clinical research. Ann Intern Med 1987;107:224-233.
5. Freeman CD, Strayer AH. Mega-analysis of meta-analysis: an examination of meta-analysis with an emphasis on once-daily aminoglycoside comparative trials. Pharmacother 1996;16:1093-1102.
6. Jadad AR, Moore RA, Carroll D, et al. Assessing the quality of reports of randomized clinical trials: is blinding necessary? Cont Clin Trials 1996;17:1-12.
7. Sackett DL. On some clinically useful measures of the effects of treatment [EBM note]. Evidence-Based Med 1996;1:37-38.
8. Brannigan, Pevalin, and Wade. Lecture 4a. A brief introduction of odds and odds ratios as measures of association soci 401-01.05 Secondary data analysis for social scientists. 1999. Available: www.ucalgary.ca/~branniga/beybio.html.
9. del Rosal PL. The efficacy and safety of isepamicin compared with amikacin in the treatment of intra-abdominal infections. J Chemother 1995;7(Suppl 2): 143-148.
10. de Vries, Verkooyen RP, Leguit P, et al. Prospective randomized study of once daily versus thrice-daily netilmicin regimens in patients with intra-abdominal infections. Eur J Clin Microbiol Infect Dis 1990; 9:161-168.
11. Dupont H, Carbon C, Carlet J. Monotherapy with a broad-spectrum beta-lactam is as effective as its combination with an aminoglycoside in treatment of severe generalized peritonitis: a multicenter randomized controlled trial. The severe generalized peritonitis study group. Antimicrob Agents Chemother 2000;44:2028-2033.
12. Harding GKM, Buckwold FJ, Ronald AR, et al. Prospective, randomized comparative study of clindamycin, chloramphenicol, and ticarcillin, each in combination with gentamicin, in therapy for intra-abdominal and female genital tract sepsis. J Infect Dis 1980;142:384-393.
13. Henning C, Meden-Britth G, Frolander F, et al. Comparative study of netilmicin/tinidazole versus netilmicin/clindamycin in the treatment of severe abdominal infections. Scand J Infect Dis 1984;16:297-303.
14. Hollender LF, Bahnini J, De Manzini N, et al. A multicenter study of netilmicin once daily versus thrice daily in patients with appendicitis and other intra-abdominal infections. J Antimicrob Chemother 1989; 23:773-783.
15. Hoogkamp-Korstanje JAA. Ciprofloxacin vs. cefotaxime regimens for the treatment of intra-abdominal infections. Infection 1995;23:278-282.
16. Kekomaki M, Louhimo I. Perforated appendix and antibiotics. Z Kinderchir 1981;32:310-314.
17. King DR, Browne AF, Birken GA, et al. Antibiotic management of complicated appendicitis. J Pediatr Surg 1983;18:945-950.
18. Lennard ES, Minshew BH, Dellinger EP, et al. Stratified outcome comparison of clindamycin-gentamicin versus chloramphenicol-gentamicin for treatment of intra-abdominal sepsis. Arch Surg 1985;120: 889-898.
19. Muth L, Eden T. High-dose tobramycin combined with clindamycin or lincomycin in the treatment of septic peritonitis and intra-abdominal sepsis. Acta Chir Scand 1981;147:339-346.
20. Nicolle LE, Harding GK, Louie TJ, et al. Cefoxitin plus tobramycin and clindamycin plus tobramycin. A prospective randomized comparison in the therapy of mixed aerobic/anaerobic infections. Arch Surg 1986;121:891-896.
21. Schieker KR, Hofmann HF. Prospective double-blind controlled clinical study of sisomicin versus tobramycin. Pharmatherapeutica 1981;2:499-503.
22. Smith JA, Skidmore AG, Forward AD, et al. Prospective, randomized, double-blind comparison of metronidazole and tobramycin with clindamycin and tobramycin in the treatment of intra-abdominal sepsis. Ann Surg 1980;192:213-220.
23. Smith JA, Forward AD, Skidmore AG, et al. Metronidazole in the treatment of intra-abdominal sepsis. Surgery 1983;93(1 Pt 2):217-220.
24. Swenson RM, Lorber B. Clindamycin and carbenicillin in the treatment of patients with intra-abdominal and female genital tract infections. J Infect Dis 1997;135(Suppl):S40-S45.
25. Tally FP, McGowan K, Kellum JM, et al. A randomized comparison of cefoxitin with or without amikacin and clindamycin plus amikacin in surgical sepsis. Ann Surg 193:318-323.
26. Tally FP, Kellum JM, Ho JL, et al. Randomized prospective study comparing moxalactam and cefoxitin with or without tobramycin for the treatment of serious surgical infections. Antimicrob Agents Chemother 1986;29:244-249.
27. Birolini D, Moraes MF, de Souza OS. Comparison of aztreonam plus clindamycin with tobramycin plus clindamycin in the treatment of intra-abdominal infections. Chemother 1989;35(Suppl 1):49-57.
28. Drusano GL, Warren JW, Saah AJ, et al. A prospective randomized controlled trial of cefoxitin versus clindamycin-aminoglycoside in mixed anaerobic-aerobic infections. Surg Gynecol Obstet 1982;154: 715-720.
29. Crombleholme W, Landers D, Ohm-Smith M, et al. Sulbactam/ampicillin versus metronidazole/gentamicin in the treatment of severe pelvic infections. Drugs 1986;31(Suppl 2):11-13.
30. Guerra JG, Casalino E, Palomino JC, et al. Imipenem/cilistatin vs. gentamicin/clindamycin for the treatment of moderate to severe infections in hospitalized patients. Rev Infect Dis 1985;7(Suppl 3): S463-S470.
31. Hackford AW, Tally FP, Reinhold RB, et al. Prospective study comparing imipenem-cilastatin with clindamycin and gentamicin for the treatment of serious surgical infections. Arch Surg 1988;123:322-326.
32. Harding G, Vincelette J, Rachlis A, et al. A preliminary report on the use of ceftizoxime vs. clindamycin/tobramycin for the therapy of intra-abdominal and pelvic infections. J Antimicrob Chemother 1982;10(Suppl C):191-192.
33. Harding GKM, Nicolle LE, Haase DA, et al. Prospective, randomized, comparative trials in the therapy for intra-abdominal and female genital tract infections. Rev Infect Dis 1984;6(Suppl 1):S283-292.
34. Joshi M, Fitzpatrick BJ, Warren JW, et al. A randomized controlled trial of moxalactam versus clindamycin/tobramycin in the treatment of mixed anaerobic/aerobic infections. Am Surg 1986;52: 467-471.
35. Poularas J, Giamarellou H, Vlachos G, et al. The treatment of gynecological and intra-abdominal infections: a comparative study of cefotetan versus netilmicin plus clindamycin. Chemioterapia 1988;7: 253-255.
36. Saario I, Arvilommi H, Silvola H. Comparison of cefuroxime and gentamicin in combination with metronidazole in the treatment of peritonitis due to perforation of the appendix. Acta Chir Scand 1983; 149:423-426.
37. Scandinavian Study Group. Imipenem/cilastatin versus gentamicin/clindamycin for treatment of serious bacterial infections. Lancet 1984;868-871.
38. Solomkin JS, Fant WK, Rivera JO, et al. Randomized trial of imipenem/cilastatin versus gentamicin and clindamycin in mixed flora infections. Am J Med 1985;78(Suppl 6A):85-91.
39. Stone HH, Fabian TC. Clinical comparison of antibiotic combinations in the treatment of peritonitis and related mixed aerobic-anaerobic surgical sepsis. World J Surg 1980;4:415-421.
40. Thadepalli H, Huang JT. Treatment of anaerobic infections: carbenicillin alone compared with clindamycin and gentamicin. Curr Ther Res 1977;22: 549-555.
41. Andaker L, Hojer H, Kihlstrom E, et al. Stratified duration of prophylactic anti-microbial treatment in emergency abdominal surgery. Acta Chir Scand 1987;153:185-192.
42. Blair JE, McLeod RS, Cohen Z, et al. Ticarcillin/clavulanic acid (timentin) compared to metronidazole/netilmicin in preventing postoperative infection after elective colorectal surgery. Can J Surg 1987;30:120-122.
43. Clarke JS, Condon RE, Bartlett JG, et al. Preoperative oral antibiotics reduce septic complications of colon operations: results of prospective, randomized, double-blind clinical study. Ann Surg 1977;186:251-259.
44. Jorgensen SJ, Weile F. Prophylactic treatment with bacitracin-neomycin and tetracycline in surgery of colon and rectum. Acta Chir Scand 1974;140:491-493.
45. Heseltine PN, Berne TV, Yellin AE, et al. The efficacy of cefoxitin vs. clindamycin/gentamicin in surgically tested stab wounds of the bowel. J Trauma 1986;26:241-245.
46. Hull C, Curran F, Burdon DW, et al. A randomized trial to compare amoxicillin/clavulanate with metronidazole plus gentamicin in prophylaxis in elective colorectal surgery. J Anti Chemother 1989;24(Suppl B):195-202.
47. Huttunen R, Laitinen S, Mokka R, et al. Comparison of metronidazole with clindamycin-gentamicin combination in the prevention of infectious complications after elective colonic surgery. Ann Chir Gynaecol 1982;71:317-320.
48. Kreis DJ, Augenstein D, Martinez O, et al. A prospective randomized study of moxalactam versus gentamicin and clindamycin in penetrating abdominal trauma. Surg Gynecol Obstet 1986;163:1-4
49. Legrand LC, Van der Auwera P, Renaux J, et al. Randomized study of minocycline + gentamicin compared with metronidazole + gentamicin for prophylaxis or treatment of mixed infections in abdominal surgery. Int J Clin Pharmacol Res 1986; 6:361-368.
50. Marti MC, Auckenthaler R. Antibiotic prophylaxis in large bowel surgery: results of controlled clinical trial. Surgery 1983;93:190-196.
51. Molin K, Rieger A. Effect of preoperative oral administration of oxytetracycline and neomycin on postoperative infectious complications in cases of cancer coli-recti. Acta Chir Scand 1979;145:177-183.
52. Moore FA, Moore EE, Ammons LA, et al. Presumptive antibiotics for penetrating abdominal wounds. Surg Gynecol Obstet 1989;169:99-103.
53. Sherlock DJ, Ward A, Holl-Allen RT. Combined preoperative antibiotic therapy and intraoperative topical povidone-iodine, reduction of wound sepsis following emergency appendectomy. Arch Surg 1984; 119:909-911.
54. Tanner AG, Thom BT, Strachan CJ. Cefotetan compared with gentamicin and tinidazole in acute abdominal surgery. J Hosp Infect 1986;7:49-59.
55. Bartlett JG, Miao PV, Gorbach SL. Empiric treatment of clindamycin and gentamicin of suspected sepsis due to anaerobic and aerobic bacteria. J Infect Dis 1977;135(Suppl):S80-S85.
56. Carlet J, Goldstein FW, Bleriot JP, et al. Timentin in the anti-microbial treatment of nosocomial and polymicrobial infections. J Antimicrob Chemother 1986;17(Suppl C):149-159.
57. del Rosal PL. A comparative study of the efficacy and safety of azlocillin and gentamicin in the treatment of serious infections. J Antimicrob Chemother 1983;11(Suppl B):159-167.
58. Fass RJ. Treatment of mixed bacterial infections with clindamycin and gentamicin. J Infect Dis 1977;135 (Suppl):S74-79.
59. Gill MA, Cheetham TC, Chenella FC, et al. Matched case-control study of adjusted versus nonadjusted gentamicin dosing in perforated and gangrenous appendicitis. Ther Drug Monit 1986;8:451-456.
60. Heseltine PN, Yellin AE, Appleman MD, et al. Impanel therapy for perforated and gangrenous appendicitis. Surg Gynecol Obstet 1986;162:43-48.
61. Kosmidis J. Management of surgical infections. Scand J Gastroenterol 1984;90:71-75.
62. Otherson HB, Campbell TW. Programmed treatment of ruptured appendicitis in children. South Med J 1974;67:903-907.
63. Pollock AA, Stein AJ, Simberkoff MD, et al. Netilmicin therapy of gentamicin-sensitive and resistant gram-negative infections. Am J Med Sci 1981; 282:2-11.
64. Roberts EA, Nealon TF Jr. Subphrenic abscess: comparison between operative and antibiotic management. Ann Surg 1974;180:209-212.
65. Rodriguez JC, Buckner D, Schoenike S, et al. Comparison of two antibiotic regimens in the treatment of perforated appendicitis in pediatric patients. Int J Clin Pharmacol Ther 2000;38:492-499.
66. Smith JA, Forward AD, Skidmore AG, et al. Metronidazole and tobramycin in intra-abdominal sepsis. Surg Gynecol Obstet 1982;155:235-237.
67. Stone HH, Kolb LD, Geheber CE, et al. Treatment of surgical infections with tobramycin. Am Surg 1975; 41:301-308.
68. Danziger LH, Creger RJ, Stellato TA, et al. A randomized trial of gentamicin and clindamycin vs. imipenem-cilastatin in serious infections. Drug Intell Clin Pharm 1985;19:455-461.
69. Stone HH, Morris ES, Kolb LD, et al. Clinical comparison of cefamandole versus gentamicin in the treatment of peritonitis. Clin Pharm Ther 1979;25: 251-258.
70. Mullick RN, Zissis NP. Piperacillin vs. gentamicin-clindamycin combination in intra-abdominal infections. Curr Ther Res 1987;41:536-541.
71. Reinhardt JF, Johnston L, Ruane P, et al. A randomized, double-blind comparison of sulbactam/ampicillin and clindamycin for the treatment of aerobic and aerobic-anaerobic infections. Rev Infect Dis 1986;8(Suppl 5):S569-S575.
72. Wong KM, Chan YH, Cheung CY, et al. Cefipime versus vancomycin plus netilmicin therapy for continuous ambulatory peritoneal dialysis-associated peritonitis. Am J Kidney Dis 2001;38:127-131.
73. Gonzenbach HR, Sonnabend W. Ceftazidime versus tobramycin plus clindamycin bei intraabdominellen infektionen. Futuramed, Munchen. Fortschritte der Antimikrobiellen und Antineoplastischen Chemterapie: FAC/Herausgegeben E.V, 1985;4-3:751-757.
74. Baird IM. Multicentered study of cefoperazone for treatment of intra-abdominal infections and comparison of cefoperazone with cefamandole and clindamycin plus gentamicin for treatment of appendicitis and peritonitis. Rev Infect Dis 1983;5(Suppl 1):S165-172.
75. Barboza E, del Castillo M, Yi A, et al. Clindamycin plus amikacin versus clindamycin plus aztreonam in established intra-abdominal infections. Surgery 1994;116:28-35.
76. Berne TV, Yellin AW, Appleman MD, et al. Antibiotic management of surgically treated gangrenous or perforated appendicitis. Am J Surg 1982;144:8-13.
77. Berne TV, Appleman MD, Chenella FC, et al. Surgically treated gangrenous or perforated appendicitis. Ann Surg 1987;205:133-137.
78. Berne TV, Yellin AE, Appleman MD, et al. A clinical comparison of cefipime and metronidazole versus gentamicin and clindamycin in the antibiotic management of surgically treated advanced appendicitis. Surg Gynecol Obstet 1993;177(Suppl):18-22.
79. Berne TV, Yellin AE, Appleman MD, et al. Meropenem versus tobramycin with clindamycin in the antibiotic management of patients with advanced appendicitis. J Am Coll Surg 1996;182:403-407.
80. Birolini D, Moraes MF, de Souza OS. Aztreonam plus clindamycin vs. tobramycin plus clindamycin for the treatment of intraabdominal infections. Rev Infect Dis 1985;7(Suppl 4):S724-728.
81. Biron S, Brochu G, Beland L, et al. Short-term antibiotic therapy for peritonitis: prospective, randomized trial comparing cefotaxime-metronidazole and clindamycin-tobramycin. J Antimicrob Chemother 1984;14(Suppl B):213-216.
82. Bubrick MP, Heim-Duthoy KL, Yellin AE, et al. Ceftazidime/clindamycin versus tobramycin/clindamycin in the treatment of intra-abdominal infections. Am Surg 1990;56:613-617.
83. Busuttil RW, McGrattan MA, Freischlag J. A comparative study of cefamandole versus gentamicin plus clindamycin in the treatment of documented or suspected bacterial peritonitis. Surg Gynecol Obstet 1984;158:1-8.
84. Ciftci AO, Tanyel C, Buyukpamukcu N, et al. Comparative trial of four antibiotic combinations for perforated appendicitis in children. Eur J Surg 1997; 163:591-596.
85. Condon RE, Walker AP, Sirinek KR, et al. Meropenem versus tobramycin plus clindamycin for treatment of intraabdominal infections: results of a prospective, randomized, double-blind clinical trial. Clin Infect Dis 1995;21:544-550.
86. Dougherty SH, Sirinek KR, Schauer PR, et al. Ticarcillin/clavulanate compared with clindamycin/gentamicin (with or without ampicillin) for the treatment of intra-abdominal infections in pediatric and adult patients. Am Surg 1995;61:207-303.
87. Eckhauser FE, Knol JA, Raper SE, et al. Efficacy of two comparative antibiotic regimens in the treatment of serious intra-abdominal infections: Results of a multicenter study. Clin Ther 1992;14:97-109.
88. Fink MP, Helsmoortel CM, Arous EJ, et al. Comparison of the safety and efficacy of parenteral ticarcillin/clavulanate and clindamycin/gentamicin in serious intra-abdominal infections. J Antimicrob Chemother 1989;24(Suppl B):147-156.
89. Gonzenbach HR, Simmen HP, Amgwerd R. Imipenem (n-f-thienamycin) versus netilmicin plus clindamycin. A controlled and randomized comparison in intra-abdominal infections. Ann Surg 1987; 205:271-275.
90. Greenberg RN, Cayavec P, Danko LS, et al. Comparison of cefoperazone plus sulbactam with clindamycin plus gentamicin as treatment for intraabdominal infections. J Antimicrob Chemother 1994; 34:391-401.
91. Gripenberg L, Nuutinen P, Elo J, et al. Tobramycin-clindamycin versus cephalothin-cephalexin in the treatment of appendicular peritonitis. Z Kinderchir 1981;34:227-235.
92. Guerra JG, Casalino E, Palomino JC, et al. Imipenem/cilistatin vs. gentamicin/clindamycin for the treatment of moderate to severe infections in hospitalized patients. Rev Infect Dis 1985;7(Suppl3): S463-S470.
93. Hopkins JA, Wilson SE, Bobey DG. Adjunctive antimicrobial therapy for complicated appendicitis: Bacterial overkill by combination therapy. World J Surg 1994;18:933-938.
94. Huizinga WKJ, Baker LW, Kadwa H, et al. Management of severe intra-abdominal sepsis: single agent antibiotic therapy with cefotetan versus combination therapy with ampicillin, gentamicin and metronidazole. Br J Surg 1988;75:1134-1138.
95. Jauregui LE, Appelbaum PC, Fabian TC, et al. A randomized clinical study of cefoperazone and sulbactam versus gentamicin and clindamycin in the treatment of intra-abdominal infections. J Antimicrob Chemother 1990;25:423-433.
96. Kooi GH, Pit S. Ceftazidime/metronidazole versus netilmicin/metronidazole in the treatment of perforated appendicitis in children. Clin Ther 1990;12:54-60.
97. Lau WY, Fan ST, Chu KW, et al. Cefoxitin versus gentamicin and metronidazole in prevention of post-appendectomy sepsis: a randomized, prospective trial. J Antimicrob Chemother 1986;18:613-619.
98. Leaper DJ, Kennedy RH, Sutton A, et al. Treatment of acute bacterial peritonitis: a trial of imipenem/cilistatin against ampicillin-metronidazole-gentamicin. Scand J Infect Dis 1987;Suppl 52:7-10.
99. Luke M, Iversen J, Sondergaard J, et al. Ceftriaxone/metronidazole is more effective than ampicillin/netilmicin/metronidazole in the treatment of bacterial peritonitis. Eur J Surg 1991;157:397-401.
100. Malangoni MA, Condon RE, Spiegel CA. Treatment of intra-abdominal infections is appropriate with single-agent or combination antibiotic therapy. Surgery 1985;98:648-655.
101. Meller JL, Reyes HM, Loeff DS, et al. One-drug versus two-drug antibiotic therapy in pediatric perforated appendicitis: A prospective randomized study. Surgery 1991;110:764-767.
102. Poenaru D, De Santis M, Christou NV. Imipenem versus tobramycin-antianaerobe antibiotic therapy in intra-abdominal infections. Can J Surg 1990;33: 415-422.
103. Polk HC, Fink MP, Wilson SE, et al. The Piperacillin/Tazobactam Intra-abdominal Study Group. Prospective randomized study of piperacillin/tazobactam therapy of surgically treated intra-abdominal infection. Am Surg 1993;59:598-605.
104. Schentag JJ, Wels PB, Reitberg DP, et al. A randomized clinical trial of moxalactam alone versus tobramycin plus clindamycin in abdominal sepsis. Ann Surg 1983;198:35-41.
105. Schmitt M, Bondonny JM, Delmas P, et al. Antibiotic therapy of perforated appendicitis in children: a comparison of amoxicillin/clavulanate with a combination of benzylpenicillin, netilmicin and metronidazole. J Antimicrob Chemother 1989;24(Suppl B): 157-163.
106. Schropp KP, Kaplan S, Golladay ES, et al. A randomized clinical trial of ampicillin, gentamicin and clindamycin versus cefotaxime and clindamycin in children with ruptured appendicitis. Surg Gynecol Obstet 1991;172:351-356.
107. Sirinek KR, Levine BA. Antimicrobial management of surgically treated gangrenous or perforated appendicitis: comparison of cefoxitin and clindamycin-gentamicin. Clin Ther 1987;9:420-428.
108. Stellato TA, Danziger LH, Hau T, et al. Moxalactam vs. tobramycin-clindamycin. a randomized trial in secondary peritonitis. Arch Surg 1988;123:714-717.
109. Stone HH, Mullins RJ, Stron PR, et al. Ceftriaxone versus combined gentamicin and clindamycin for polymicrobial surgical sepsis. Am J Surg 1984;148: 30-34.
110. Strom PR, Stone HH, Fabian TC. Moxalactam versus gentamicin-clindamycin for the treatment of infections within the abdominal cavity. Contemp Surg 1982;20:39-42.
111. Study Group of Intraabdominal Infections. A randomized controlled trial of ampicillin plus sulbactam vs. gentamicin plus clindamycin in the treatment of intraabdominal infections: a preliminary report. Rev Infect Dis 1986;8(Suppl 5):S583-S588.
112. Shyr YM, Lui WY, Su CH, et al. Piperacillin/tazobactam in comparison with clindamycin plus gentamicin in the treatment of intra-abdominal infections. Chinese Med J 1995;56:102-108.
113. Sirinek KR, Levine BA. A randomized trial of ticarcillin and clavulanate versus gentamicin and clindamycin in patients with complicated appendicitis. Surg Gynecol Obstet 1991;172(Suppl)S30-S35.
114. Solomkin JS, Dellinger EP, Christou NV, et al. Results of a multicenter trial comparing imipenem/cilistatin to tobramycin/clindamycin for intra-abdominal infections. Ann Surg 1990;212:581-591.
115. Stone HH, Geheber CE, Kolb LD, et al. Clinical comparison of cefotaxime versus the combination of gentamicin plus clindamycin in the treatment of peritonitis and similar polymicrobial soft-tissue surgical sepsis. Clin Ther 1981;4(Suppl A):67-80.
116. Swedish Study Group. A randomized multicentre trial of pefloxacin plus metronidazole and gentamicin plus metronidazole in the treatment of severe intra-abdominal infections. J Antimicrob Chemother 1990;26(Suppl B):173-180.
117. Torres AJ, Valladares D, Jover JM, et al. Cefminox versus metronidazole plus gentamicin in intra-abdominal infections: a prospective randomized controlled clinical trial. Infection 2000;28:318-322.
118. Wilson SE. Results of a randomized, multicenter trial of meropenem versus clindamycin/tobramycin for the treatment of intra-abdominal infections. Clin Infect Diseases 1997;24(Suppl 2):S197-S206.
119. Williams RR, Hotchkin D. Aztreonam plus clindamycin versus tobramycin plus clindamycin in the treatment of intraabdominal infections. Rev Infect Dis 1991;13(Suppl. 7):S629-S633.
120. Yellin AE, Heseltine PNR, Berne TV, et al. The role of Pseudomonas species in patients treated with ampicillin and sulbactam for gangrenous and perforated appendicitis. Surg Gynecol Obstet 1985;161:303-307.
121. Solomkin JS, Hemsell DL, Sweet R, et al. General guidelines for the evaluation of new anti-infective drugs for the treatment of intra-abdominal and pelvic infections. Clin Infect Dis 1992;15(Suppl 1):S33-42.
122. Bohnen J. Antibiotic therapy for abdominal infection. World J Surg 1998;22:152-157.
123. Ho JL, Barza M. Role of aminoglycoside antibiotics in the treatment of intra-abdominal infection. Antimicrob Agents Chemother 1997;31:485-491.
124. DiPiro JT, Forston NS. Combination antibiotic therapy in the management of intra-abdominal infection. Am J Surg 1993;165:Suppl: 82S-88S.
125. Juni P, Altman DG, Egger M. Assessing the quality of controlled clinical trials. BMJ 2001;323:42-46.
126. Cho MK, Bero LA. Instruments for assessing the quality of drug studies published in the medical literature. JAMA 1994;272:101-104.
127. The Standards of Reporting Trials Group. A proposal for structured reporting of randomized controlled trials. JAMA 1994;272:1926-1931.
128. Solomkin JS, Meakins JL, Allo MD, et al. Antibiotic trials in intra-abdominal infections: a critical evaluation of study design and outcome reporting. Ann Surg 1984;200:29-39.