Active immunotherapy with anti-idiotypic antibody for patients with nasopharyngeal carcinoma (NPC)

Cancer Biotherapy and Radiopharmaceuticals

Volumn 17, Issue 6, 2002, Pages 673-679

  Li, Guancheng ^a   Xie, Lu ^a   Zhou, Guohua ^a   Zhu, Jiangao ^a   Hu, Jinyue ^a   Sun, Qubing ^a  

^a Central South University   (China)

Author keywords

Active immunotherapy; Anti idiotypic antibody; Nasopharyngeal carcinoma

Indexed keywords

ALUMINUM HYDROXIDE; ANTIIDIOTYPIC ANTIBODY; GAMMA INTERFERON; INTERLEUKIN 2; MESSENGER RNA; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 2H4; MONOCLONAL ANTIBODY 5D3; MONOCLONAL ANTIBODY FC2; MONOCLONAL ANTIBODY HNL5; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CANCER IMMUNOTHERAPY; CANCER RADIOTHERAPY; CANCER STAGING; CELLULAR IMMUNITY; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFECT; DRUG EFFICACY; DRUG HYPERSENSITIVITY; DRUG SAFETY; DRUG TOXICITY; FEMALE; HUMAN; HUMAN TISSUE; HUMORAL IMMUNITY; IN SITU HYBRIDIZATION; MALE; MONONUCLEAR CELL; MOUSE; NASOPHARYNX CARCINOMA; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RANDOMIZED CONTROLLED TRIAL;

EID: 0036925082     PISSN: 10849785     EISSN: None     Source Type: Journal    
DOI: 10.1089/108497802320970280     Document Type: Article

References (16)

1. Jerne NK. Towards a network theory of the immune responses. Ann Immunol Paris 1974;125C:373-389.
2. Grzych JM, Capron M, Lambert PH, et al. An anti-iditype vaccine against experimental schistosomiasis. Nature 1985;316:74-76.
3. McNamara MK, Ward RE, Kohler H. Monoclonal idiotype vaccine against streptococcus. Science 1984;226:1325-1326.
4. Kenney RC, Eichberg JW, Lanford RE, et al. Anti-idiotypic antibody vaccine for type B viral hepatitis in chimpanzees. Science 1986;232:220-223.
5. Mittelman A, Chen ZJ, Yang H, et al. Human high molecular weight melanoma-associated antigen (HMWMAA) mimicry by mouse anti-idiotypic monoclonal antibody MK2-23: Induction of humoral anti-HMWMAA immunity and prolongation of survival in patients with stage IV melanoma. Proc Natl Acad Sci USA 1992;89:466-470.
6. Foon KA, Sen G, Hutchins L, et al. Antibody responses in melanoma patients immunized with an anti-idiotype antibody mimicking disialoganglioside GD2. Clin Cancer Res 1998;4:1113-1124.
7. Herlyn D, Wettendorff M, Schmoll E, et al. Anti-idiotype immunization of cancer patients: Modulation of the immune response. Proc Natl Acad Sci USA 1987;84:8055-8059.
8. Durrant LG, Buckley TJD, Denton GWL, et al. Enhanced cell-mediated tumor killing in patients immunized with human monoclonal anti-idiotypic antibody 105AD7. Cancer Res 1994;54:4837-4840.
9. Fagerberg J, Steinitz M, Wigzell H, et al. Human anti-idiotypic antibodies induced a humoral and cellular immune response against a colorectal carcinoma-associated antigen in patients. Proc Natl Acad Sci USA 1995; 92:4773-4777.
10. Somasundaram R, Zaloudik J, Jacob L, et al. Induction of antigen-specific T and B cell immunity in colon carcinoma patients by anti-idiotypic antibody. J Immunol 1995;155:3253-3261.
11. Foon KA, John WJ, Chakraborty M, et al. Clinical and immune responses in advanced colorectal cancer patients treated with anti-idiotype monoclonal antibody vaccine that mimics the carcinoembryonic antigen. Clin Cancer Res 1997;3:1267-1276.
12. Schultes BC, Baum RP, Niesen A, et al. Anti-idiotype induction therapy: Anti-CA125 antibodies (Ab3) mediated tumor killing in patients treated with ovarex mAb B43.13 (Ab1). Cancer Immunol Immunother 1998;46:201-212.
13. Li GC, Zhu JG, Zhou GH, et al. Production of monoclonal antibodies against nasopharyngeal cancer (NPC) by in vivo and vitro combining immunization. Hunan Med J 1999;16:326-328.
14. Li GC, Zhou GH, Zhu JG, et al. Study of monoclonal anti-idiotype antibody that bears the internal image of nasopharyngeal carcinoma associated antigen. Bull Hunan Med Univ 2000;25:319-322.
15. Chen ZJ, Yang H, Ferrone S. Human high molecular weight melanoma-associated antigen mimicry by mouse anti-idiotypic monoclonal antibody MK2-23. J Immunol 1991;147:1082-1090.
16. Bona CA. Idiotype vaccines: Forgotten but not gone. Nat Med 1998;4:668-669.