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Cancer Biotherapy and Radiopharmaceuticals

Volumn 17, Issue 6, 2002, Pages 665-671

Fusion of the CH1 domain of IgG1 to epidermal growth factor (EGF) prolongs its retention in the blood but does not increase tumor uptake

(8) Wang, Judy a Reilly, Raymond M a,b,d,e Chen, Paul a Yang, Shaoxian b Bray, Mark R b Gariépy, Jean b,d Chan, Conrad c Sandhu, Jasbir c

a UNIVERSITY HEALTH NETWORK (Canada)

b UNIVERSITY OF TORONTO (Canada)

c MOUNT SINAI HOSPITAL (Canada)

d UNIVERSITY OF TORONTO (Canada)

e TORONTO GENERAL HOSPITAL (Canada)

Author keywords

Epidermal growth factor; Fusion protein; Immunoglobulin; Iodine 123

Indexed keywords

EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; HUMAN EPIDERMAL GROWTH FACTOR C H 1 FUSION PROTEIN; HYBRID PROTEIN; IMMUNOGLOBULIN G1; PROTEIN C H 1; UNCLASSIFIED DRUG; DIAGNOSTIC AGENT; IMMUNOGLOBULIN G; IMMUNOGLOBULIN HEAVY CHAIN; RADIOACTIVE IODINE;

AFFINITY CHROMATOGRAPHY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST CANCER; CANCER CELL; CONTROLLED STUDY; DIAGNOSTIC VALUE; DRUG DISTRIBUTION; DRUG RECEPTOR BINDING; DRUG UPTAKE; ENZYME DEGRADATION; EXPRESSION VECTOR; GENE FUSION; MOUSE; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN ISOLATION; PROTEIN LOCALIZATION; RECOMBINANT GENE; TUMOR XENOGRAFT; WESTERN BLOTTING; ANIMAL; EXPERIMENTAL NEOPLASM; FEMALE; HUMAN; IMMUNOGLOBULIN CONSTANT REGION; METABOLISM; PLASMID;

ANIMALS; BLOTTING, WESTERN; ELECTROPHORESIS, POLYACRYLAMIDE GEL; EPIDERMAL GROWTH FACTOR; FEMALE; HUMANS; IMMUNOGLOBULIN CONSTANT REGIONS; IMMUNOGLOBULIN G; IMMUNOGLOBULIN HEAVY CHAINS; IODINE RADIOISOTOPES; MAMMARY NEOPLASMS, EXPERIMENTAL; MICE; PLASMIDS; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECOMBINANT FUSION PROTEINS;

EID: 0036921677 PISSN: 10849785 EISSN: None Source Type: Journal
DOI: 10.1089/108497802320970271 Document Type: Article

Times cited : (3)

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