Saline containing phosphatidylcholine liposomes possess the ability to restore endothelial function damaged resulting from G-irradiation

Journal of Physiology and Pharmacology

Volumn 53, Issue 4 I, 2002, Pages 701-712

  Soloviev, A I ^a   Stefanov, A V ^a   Tishkin, S M ^a   Khromov, A S ^a   Parshikov, A V ^a   Ivanova, I V ^a   Gurney, A M ^b  

^a STATE INSTITUTION NATIONAL RESEARCH CENTER FOR RADIATION MEDICINE OF THE NATIONAL ACADEMY OF MEDICAL SCIENCES OF UKRAINE   (Ukraine)

^b UNIVERSITY OF STRATHCLYDE   (United Kingdom)

Author keywords

irradiation; Endothelium; Nitric oxide (NO); NO donors. phosphatidylcholine liposomes

Indexed keywords

ACETYLCHOLINE; LIPOSOME; NITRIC OXIDE; NITRIC OXIDE DONOR; PHOSPHATIDYLCHOLINE; SODIUM CHLORIDE;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIAL PRESSURE; BLOOD VESSEL INJURY; BLOOD VESSEL TONE; CONFERENCE PAPER; CONTROLLED STUDY; DRUG EFFECT; DRUG RESPONSE; ENDOTHELIUM CELL; GAMMA IRRADIATION; HEART MUSCLE CONTRACTILITY; HUMAN; IONIZING RADIATION; NONHUMAN; OXIDATIVE STRESS; RABBIT; RADIATION ACCIDENT; RADIATION INJURY; VASCULAR ENDOTHELIUM; VASCULAR RING; VASODILATATION;

ACETYLCHOLINE; ADULT; ANIMALS; AORTA, THORACIC; BLOOD PRESSURE; ENDOTHELIUM, VASCULAR; GAMMA RAYS; HUMANS; LIPOSOMES; MIDDLE AGED; NITRIC OXIDE DONORS; PHOSPHATIDYLCHOLINES; RABBITS; RATS; RATS, INBRED WKY; RECOVERY OF FUNCTION; SODIUM CHLORIDE; VASOCONSTRICTION; VASODILATOR AGENTS;

EID: 0036916887     PISSN: 08675910     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (19)

1. nd Int. Conf. Long-term Health Consequences of the Chernobyl Disaster. World Health Organization - Chernobylinterinfom, Kiev, 1998, pp. 398-399.
2. nd Int. Conf. Long-term Health Consequences of the Chernobyl Disaster. World Health Organization Chernobylinterinfom, Kiev, 1998, pp.274-275.
3. rd Int. Conf. Health effects of the Chernobyl accident: results of the 15-year follow-up studies), 2001, Kiev, Ukraine.
4. Wong FL, Yamada M, Sasaki Y, Kodama K, Akiba S, Shimaoka K, Hosoda Y. Noncancer disease incidence in the atomic bomb survivors: 1958-1986. Radiat Res 1993; 135: 418-430.
5. Menendez JC, Casanova D, Amado JA, Salas E, Garsia-Unzueta MT, Fernandez F, Perez de la Lastra M, Berrazueta JR. Effects of radiation on endothelial function. I J Radiation Oncolog Biol Physiol 1998; 41: 905-913.
6. 60. Br J Pharmacol 1998; 123: 653-660.
7. Sugihara T, Hattori Y, Yamamoto Y, Qi FZ, Ichikawa R, Sato A, Liu MY, Abe K, Canno M. Preferential impairment of nitric oxide-dependent relaxation in human cervical arteries after irradiation. Circulation 1999; 100: 635-641.
8. Soloviev AI, Tishkin SM, Parshikov AV, Mosse IV, Stefanov AV, Osipenko ON, Gurney AM. Mechanisms of endothelial dysfunction after ionised irradiation and its prevention by alphatocopherol. J Physiol 2000; 531P, 8P.
9. Soloviev AI, Tishkin SM, Parshikov AV, Mosse IV, Stefanov AV, Osipenko ON, Gurney AM. The EDHF-dependent but- not the NO-dependent component of the acetylcholine-induced relaxation of the rabbit aortas resistant to ionized radiation. In: EDHF-2000 (ed. P. Vanhoutte), Taylor & Francis, London-New York, 2001; 400-409.
10. Soloviev AI, Stefanov AV, Bazilyuk OV, Sagach VF. Phospholipid vesicles (liposomes) restore endothelium-dependent cholinergic relaxation in thoracic aorta from spontaneously hypertensive rats. J Hyperten 1993; 11: 623-627.
11. Furchott RF, Zawadski JV. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle to acetylcholine. Nature 1980; 288: 373-376.
12. Davies M. The pathological basis of angina pectoris. Cardiovasc Drugs Ther 1989; 3: 249-255.
13. Wallance P, Calvet A, Collier J. The vascular endothelium in diabetes and hypertension. Hypertens 1992; 10, Suppl 1: S25-S29.
14. Soloviev AI, Tishkin SM, Parshikov AV, Mosse IV, Stefanov AV, Osipenko ON, Gurney AM. Mechanisms of endothelial dysfunction after ionized irradiation and its prevention by atocopherol. J Physiol 2000a; 531P, 8P.
15. Soloviev AI, Tishkin SM, Parshikov AV, Mosse IV, Stefanov AV, Osipenko ON, Gurney AM. The EDHF-dependent but not the NO-dependent component of the acetylcholine-induced relaxation of the rabbit aortas resistant to ionized radiation. In EDHF-2000, P. Vanhoutte (ed) Taylor&Francis, London-New York, 2000b, pp. 400-409.
16. Pozharov VP, Miniailenko TD, Stefanov AV. Some physiological mechanisms of antihypoxic effects of liposomes. Sechenov Physiol J USSR 1990; 76: 897-902.
17. Kudryashev YB. Radiation lesion of "crucial systems". In Radiation Lesion, Yu. Kudryashov, (ed). Moscow, 1987, pp. 3-72.
18. Mead JF. Free radical mechanisms in lipid peroxidation and prostaglandins synthesis. In Free Radicals in Molecular Biology, Aging and Disease, D. Armstrong (ed), Raven Press, New York, 1984, pp. 53-66.
19. Serkiz YI. Peculiarities of the low efficiency radiation biological effects. In Chernobyl Catastrophe, V. Baryakhtar V. (ed), Editorial House of Annual Issue "Export of Ukraine", Kiev, 1997, pp. 279-281.