Variability in β-adrenergic receptor response in the vasculature: Role of receptor polymorphism

Journal of Allergy and Clinical Immunology

Volumn 110, Issue 6 SUPPL., 2002, Pages

  Wood, Alastair J J ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Ethnicity; Hypertension; Pharmacogenetics; Vascular response; adrenergic receptors

Indexed keywords

BETA ADRENERGIC RECEPTOR; ISOPRENALINE; PHENYLEPHRINE;

BLOOD VESSEL REACTIVITY; BLOOD VESSEL TONE; CONFERENCE PAPER; ETHNIC GROUP; FOREARM BLOOD FLOW; GENE FREQUENCY; GENOTYPE; HAPLOTYPE; HUMAN; HYPERTENSION; MAJOR CLINICAL STUDY; PHARMACOGENETICS; PRIORITY JOURNAL; PROTEIN POLYMORPHISM; VASCULARIZATION; VASOCONSTRICTION; VASODILATATION;

EID: 0036915796     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1067/mai.2002.129701     Document Type: Conference Paper

References (7)

1. Stein CM, Nelson R, Deegan R, He H, Wood M, Wood AJJ. Forearm beta adrenergic receptor-mediated vasodilation is impaired, without alteration of forearm norepinephrine spillover, in borderline hypertension. J Clin Invest 1995;96:579-85.
2. Lang CC, Stein CM, Brown RM, Deegan R, Nelson R, He HB, et al. Attenuation of isoproterenol-mediated vasodilatation in blacks. N Engl J Med 1995;333:155-60.
3. Stein CM, Lang CC, Singh I, He HB, Wood AJJ. Increased vascular adrenergic vasoconstriction and decreased vasodilation in blacks: Additive mechanisms leading to enhanced vascular reactivity. Hypertension 2000;36:945-51.
4. 2-adrenoceptor. Hypertension 1997;30:773-6.
5. Timmermann B, Mo R, Luft FC, Gerdts E, Busjahn A, Omvik P, et al. β-2 adrenoceptor genetic variation is associated with genetic predisposition to essential hypertension: The Bergen blood pressure study. Kidney Int 1998;53:1455-60.
6. 2-adrenergic receptor polymorphisms: No association with essential hypertension in black or white Americans. Clin Pharmacol Ther 2000;67:670-5.
7. 2-adrenergic receptor on agonist-mediated vascular desensitization. N Engl J Med 2001;345:1030-5.