Ketamine psychotherapy for heroin addiction: Immediate effects and two-year follow-up

Journal of Substance Abuse Treatment

Volumn 23, Issue 4, 2002, Pages 273-283

  Krupitsky, Evgeny ^a   Burakov, Andrey ^a   Romanova, Tatyana ^a   Dunaevsky, Igor ^a   Strassman, Rick ^a   Grinenko, Alexander ^a  

^a St Petersburg Regional Center   (Russian Federation)

Author keywords

Hallucinogens; Heroin Addiction; Ketamine; Psychedelics; Psychotherapy; Treatment

Indexed keywords

DIAMORPHINE; KETAMINE; ANESTHETIC AGENT; PSYCHEDELIC AGENT;

ADOLESCENT; ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG MEGADOSE; DRUG WITHDRAWAL; EMOTIONALITY; FEMALE; FOLLOW UP; HEROIN DEPENDENCE; HUMAN; HYPERTENSION; LOW DRUG DOSE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PSYCHOTHERAPIST; PSYCHOTHERAPY; QUANTITATIVE ANALYSIS; RANDOMIZED CONTROLLED TRIAL; RATING SCALE; TREATMENT OUTCOME; WITHDRAWAL SYNDROME; ANXIETY; ATTITUDE; CONTROL; DEPRESSION; LIFE EVENT; METHODOLOGY; MINNESOTA MULTIPHASIC PERSONALITY INVENTORY; PSYCHOLOGICAL ASPECT; STATISTICS;

ADOLESCENT; ADULT; ANESTHETICS, DISSOCIATIVE; ANXIETY; ATTITUDE; DEPRESSION; DOUBLE-BLIND METHOD; FEMALE; FOLLOW-UP STUDIES; HALLUCINOGENS; HEROIN DEPENDENCE; HUMANS; INTERNAL-EXTERNAL CONTROL; KETAMINE; LIFE CHANGE EVENTS; MALE; MMPI; PSYCHOTHERAPY; TREATMENT OUTCOME;

EID: 0036911275     PISSN: 07405472     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0740-5472(02)00275-1     Document Type: Article

References (34)

1. Bazhin E.F., Golynkina E.A., Etkind A.M. Locus of Control Questionnaire. 1993;Smysl, Moscow. in Russian.
2. Berman R.M., Cappiello A., Anand A., Oren D.A., Heninger G.R., Charney D.S., Krystal J.H. Antidepressant effects of ketamine in depressed patients. Biological Psychiatry. 47:2000;351-354.
3. Binienda Z.K., Scallet A.C., Schmued L.C., Ali S.F. Ibogaine neurotoxicity assessment: electrophysiological, neurochemical, and neurohistological methods. Alkaloids Chem Biol. 56:2001;193-210.
4. Bowdle T.A., Radant A.D., Cowley D.S., Kharash E.D., Strassman R.J., Roy-Byrne P.P. Psychedelic effects of ketamine in healthy volunteers. Anesthesiology. 88:1998;82-88.
5. Corrington J.E. Spirituality and recovery: Relationship between levels of spirituality, contentment and stress during recovery from alcoholism in AA. Alcoholism Treatment Quarterly. 6:1989;151-165.
6. Crumbaugh J.S. Cross-validation of Purpose-in-Life Test based on Frankl's concept. Journal of Individual Psychology. 24:1968;74-81.
7. Dahlstrom W.G., Welsh G.S., Dahlstrom L.E. An MMPI handbook: Vol. 1: Clinical interpretation. 1972;University of Minnesota Press, Minneapolis.
8. Etkind A.M. Color test of attitudes and its use in the study of neurotic patients. Bazhin E.F. Social-psychological studies in psychoneurology. 1980;110-114 Leningrad Research Psychoneurological Institute, Leningrad. in Russian.
9. Frankl V. The Unheard Cry for Meaning. 1978;Simon and Schuster, New York.
10. Glick S.D., Maisonneuve I.M., Szumlinski K.K. 18-Methoxycoronaridine (18-MC) and ibogaine: comparison of antiaddictive efficacy, toxicity, and mechanisms of action. Annuals of the New York Academy of Sciences. 914:2000;369-386.
11. Grinspoon L., Bakalar J.B. Psychedelic drugs reconsidered. 1979;Basic Books, New York.
12. Halpern J.H. The use of psychedelics in the treatment of addictions. Addiction Research. 4:1996;177-189.
13. Jansen K.L.R. The ketamine model of the near-death experience: a central role for the NMDA receptor. Journal of Near-Death Studies. 16:1997;5-27.
14. Jansen K.L.R. Ketamine: Dreams And realities. 2001;MAPS, Sarasota, FL.
15. Krupitsky E.M., Grinenko A.Y. Ketamine psychedelic therapy (KPT): A review of the results of ten years of research. Journal of Psychoactive Drugs. 29:1997;165-183.
16. Krupitsky E.M., Burakov A.M., Romanova T.N., Vostrikov V.V., Grinenko A.Y. The syndrome of anhedonia in recently detoxified heroin addicts. Building International Research on Drug Abuse: Global Focus on Youth. 1998;25 NIDA, Washington, DC.
17. Krupitsky E.M., Burakov A.M., Romanova T.N., Vostrikov V.V., Grinenko A.Y. The syndrome of anhedonia in recently detoxified heroin addicts: Assessment and treatment. MAPS Bulletin. 9:1999;40-41.
18. Kurland A.A., Savage C., Pahnke W.N., Grof S., Olsson J.E. LSD in the treatment of alcoholics. Pharmakopsychiatrie Neuropsychopharmakologie. 4:1971;83-94.
19. Leontiev D.A. Test of the Meaning of Life Orientations. 1992;Smysl, Moscow. in Russian.
20. Leuner H. Guided affective imagery: An account of its developmental history. Journal of Mental Imagery. 1:1977;73-91.
21. Lotsof H.S. Ibogaine in the treatment of chemical dependency disorders: clinical perspectives. MAPS Bulletin. 5:1995;16-27.
22. Mash D.C., Kovera C.G., Buck B.E., Norenberg M.D., Shapshak P., Hearn W.L., Sanchez-Ramos J. Medication development of ibogaine as a pharmacotherapy for drug dependence. Annals of the New York Academy of Sciences. 1998;274-292.
23. Nunes E.V., Quitkin F.M., Donovan S.J., Deliyannides D., Ocepek-Welikson K., Koenig T., Brady R., McGrath P., Woody G. Imipramine treatment of opiate-dependent patients with depressive disorders. Archive of General Psychiatry. 55:1998;153-160.
24. Phares E.J. Locus of control in personality. 1976;New Jersey General Learning Press, Morristown, New Jersey.
25. Ring K. Heading toward OMEGA. 1984;William Morrow and Company Inc. New York.
26. Sass H., Soyka M., Mann K., Zieglgansberger W. Relapse prevention by acamprosate. Archive of General Psychiatry. 53:1996;673-680.
27. Savage C., McCabe O.L. Residential psychedelic (LSD) therapy for narcotic addicts. Archive of General Psychiatry. 28:1973;808-814.
28. Spielberger C.D., Anton W.D., Bedell J. The nature and treatment of test anxiety. Zuckerman M., Spielberger C.D. Emotion and anxiety: New concepts, methods and applications. 1976;Erlbaum, Hillsdale, New Jersey.
29. Strassman R.J. Hallucinogenic drugs in psychiatric research and treatment. Perspectives and prospects. Journal of Nervous and Mental Disease. 183:1995;127-138.
30. Strassman R.J. Human psychopharmacology of N, N-dimethyltryptamine. Behavior and Brain Research. 73:1996;121-124.
31. Strassman R.J., Qualls C.R., Uhlenhuth E.H., Kellner R. Dose-response study of N, N-dimethyltryptamine in humans. II. Subjective effects and preliminary results of a new rating scale. Archive of General Psychiatry. 51:1994;98-108.
32. Strassman R.J., Qualls C.R., Berg L.M. Differential tolerance to biological and subjective effects of four closely-spaced doses of N, N-dimethyltryptamine in humans. Biological Psychiatry. 39:1996;784-795.
33. Whitfield C.L. Stress management and spirituality during recovery: a transpersonal approach. Part 1: Becoming. Alcoholism Treatment Quarterly. 1:1984;3-54.
34. Zung W.W.K. A self-rating depression scale. Archive of General Psychiatry. 12:1965;63-70.