The molar ratio of retinol-binding protein to transthyretin in the assessment of vitamin A status in adults. Proposal of a cut-off point

Clinical Chemistry and Laboratory Medicine

Volumn 40, Issue 12, 2002, Pages 1301-1307

  Zago, Liliana B ^a   Dupraz, Hernan ^a   Sarchi, María I ^b   Río, María E ^a,c  

^a Department of Nutrition/Food Science ^*  (Argentina)

^b UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^c Consejo Nacional Inves Cientificas ^*  (Argentina)

Author keywords

Retinol binding protein; Transthyretin; Vitamin A

Indexed keywords

PREALBUMIN; RETINOL; RETINOL BINDING PROTEIN;

ADULT; AGED; ANALYTIC METHOD; AREA UNDER THE CURVE; CLINICAL ARTICLE; CLINICAL CHEMISTRY; CONTROLLED STUDY; FEMALE; HUMAN; MALE; PREDICTION; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN DETERMINATION; RECEIVER OPERATING CHARACTERISTIC; REFERENCE VALUE; RETINOL DEFICIENCY; REVIEW; SENSITIVITY AND SPECIFICITY; SURGICAL PATIENT; VITAMIN BLOOD LEVEL;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; FEMALE; HUMANS; MALE; MIDDLE AGED; PREALBUMIN; PREDICTIVE VALUE OF TESTS; RETINOL-BINDING PROTEINS; VITAMIN A; VITAMIN A DEFICIENCY;

EID: 0036910671     PISSN: 14346621     EISSN: None     Source Type: Journal    
DOI: 10.1515/CCLM.2002.224     Document Type: Review

References (26)

1. Rosales FJ, Ritter SJ, Zolfagari R, Smith JE, Ross AC. Effect of acute inflammation on plasma retinol, retinol-binding protein, and the mRNA in liver and kidneys of vitamin A sufficient rats. J Lipid Res 1996; 37:962-71.
2. Mitra AK, Alvarez JO, Wahed MA, Fuchs GJ, Stephensen CB. Predictors of serum retinol in children with shigellosis. Am J Clin Nutr 1998; 68:1088-94.
3. Christian P, Schulze K, Stoltzfus RJ, West KP Jr. Hyporetinolemia, illness symptoms, and acute phase protein response in pregnant women with and without night blindness. Am J Clin Nutr 1998; 67:1237-43.
4. Rosales FJ, Ross AC. Acute inflammation induces hyporetinemia and modifies the plasma and tissue response to vitamin A supplementation in marginally vitamin A-deficient rats. J Nutr 1998; 128:960-6.
5. Rosales FJ, Topping JD, Smith JE, Shankar AH, Ross AC. Relation of serum retinol to acute phase proteins and malarial morbidity in Papua New Guinea children. Am J Clin Nutr 2000; 71:1580-8.
6. Semba RD, Muhilal West KP Jr, Natadisastra G, Eisinger W, Lan Y, Sommer A. Hyporetinolemia and acute phase proteins in children with and without xerophthalmia. Am J Clin Nutr 2000; 72:146-53.
7. Ross AC. Addressing research questions with national survey data -the relation of vitamin A status to infection and inflammation. Am J Clin Nutr 2000; 72:1069-70.
8. Stephensen CB, Gildengorin G. Serum retinol, the acute phase response, and the apparent misclassification of vitamin A status in the third National Health and Nutrition Examination survey. Am J Clin Nutr 2000; 72:1170-8.
9. Campos F, Flores H, Underwood BA. Effect of an infection on vitamin A status of children as measured by the relative dose response (RDR). Am J Clin Nutr 1987; 46:91-4.
10. Rosales FJ. The molar ratio of serum retinol-binding protein (RBP) to transthyretin (TTR) as a simple indirect method to assess vitamin A status during infection and inflammation. Sight & Life Newsletter 1997; 4:31 -4.
11. Rosales FJ, Ross AC. A low molar ratio of retinol-binding protein to transthyretin indicates vitamin A deficiency during inflammation: studies in rats and a posteriori analysis of vitamin A-supplemented children with measles. J Nutr 1998; 128:1681-7.
12. Solberg HE. Establishment and use of reference values. In: Burtis CA, Ashwood ER, editors. Tietz Textbook of Clinical Chemistry. Philadelphia: WB Saunders, 1999:336-56.
13. Mc Neil BJ, Keeler E, Adelstein SJ. A primer on certain elements of medical clinical decision-making. N Engl J Med 1975; 293:211-5.
14. Johnson AM, Rohlfs EM, Silverman LM. Proteins. In: Burtis CA, Ashwood ER, editors. Tietz Textbook of Clinical Chemistry. Philadelphia: WB Saunders, 1999:477-540.
15. Bieri JG, Tolliver TJ, Catignani GL. Simultaneous determination of α-tocopherol and retinol in plasma or red cells by high pressure liquid chromatography. Am J Clin Nutr 1979; 32:2143-9.
16. Sauberlich HE. Retinol (Vitamin A). In: Wolinsky I, editor. Laboratory tests for the assessment of nutritional status. Boca Raton, FL: CRC Press, 1999:195-231.
17. Detsky AS, Baker JP, Mendelson RA, Wolman SL, Wesson DE, Jeejeebhoy KN. Evaluating the accuracy of nutritional assessment techniques applied to hospitalized patients: methodology and comparisons. J Parenter Enteral Nutr 1984; 8:153-9.
18. Habicht JP. Some characteristics of indicators of nutritional status for use in screening and surveillance. Am J Clin Nutr 1980; 33:531-5.
19. Stephensen CB. When does hyporetinolemia mean vitamin A deficiency? Am J Clin Nutr 2000; 72:1-2.
20. Beisel WR. Infection-induced depression of serum retinol -a component of the acute phase response or a consequence? Am J Clin Nutr 1998; 68:993-4.
21. Ingenbleek Y, Bernstein L. The stressful condition as a nutritionally dependent adaptive dichotomy. Nutrition 1999; 15:305-20.
22. Young B, Gleeson M, Cripps AW. C-reactive protein: a critical review. Pathology 1991; 23:118-24.
23. Gibson RS. Principles of nutritional assessment. New York: Oxford University Press, 1990:13pp.
24. Filteau SM, Willumsen JF, Sullivan K, Simmank K, Gamble M. Use of retinol-binding protein: transthyretin ratio for assessment of vitamin A status during the acute-phase response. Br J Nutr 2000; 83:513-20.
25. Donnen Ph, Dramaix M, Brasseur D, Bitwe R, Bisimwa G, Hennart Ph. The molar ratio of serum retinol-binding protein (RBP) to transthyretin (TTR) is not useful to assess vitamin A status during infection in hospitalized children. Eur J Clin Nutr 2001; 55:1043-7.
26. Rosales FJ, Chow K, Smith JE, Shankar AH, Haskell MJ. Retinol transport proteins as indicators of vitamin A (VA) status [abstract]. The FASEB Journal 2001; 15:A603.