A minigene containing four discrete cis elements recapitulates GATA-1 gene expression in vivo

Genes to Cells

Volumn 7, Issue 12, 2002, Pages 1243-1254

  Ohneda, Kinuko ^a   Shimizu, Ritsuko ^a   Nishimura, Shigeko ^a   Muraosa, Yasushi ^a   Takashi, Satoru ^d   Engel, James Douglas ^b,c   Yamamoto, Masayuki ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

^b NORTHWESTERN UNIVERSITY   (United States)

^c UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^d NONE

Author keywords

[No Author keywords available]

Indexed keywords

CIS ACTING ELEMENT; COMPLEMENTARY DNA; THYMIDINE KINASE; TRANSCRIPTION FACTOR GATA 1;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DNA FLANKING REGION; EMBRYO; EMBRYO CULTURE; EMBRYOTOXICITY; ERYTHROID CELL; EXON; GENE ACTIVATION; GENE EXPRESSION; GENE FUNCTION; GENE LOCATION; GENETIC LINKAGE; GENETIC TRANSCRIPTION; HEMATOPOIESIS; HUMAN; IN VIVO STUDY; MOUSE; MOUSE MUTANT; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN MOTIF; REGULATORY SEQUENCE; REPORTER GENE; TISSUE SPECIFICITY; TRANSGENIC MOUSE;

ANIMALS; BASE SEQUENCE; CELLS, CULTURED; DNA-BINDING PROTEINS; EMBRYO; ERYTHROID PROGENITOR CELLS; ERYTHROID-SPECIFIC DNA-BINDING FACTORS; GATA1 TRANSCRIPTION FACTOR; GENE EXPRESSION REGULATION; GENES, REPORTER; HEMATOPOIESIS; HUMANS; INTRONS; MICE; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; NUCLEAR PROTEINS; REGULATORY SEQUENCES, NUCLEIC ACID; REPRESSOR PROTEINS; SEQUENCE ALIGNMENT; TRANSCRIPTION FACTORS;

ANIMALIA; MUS MUSCULUS;

EID: 0036910536     PISSN: 13569597     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2443.2002.00595.x     Document Type: Article

References (21)

1. Fujiwara, Y., Browne, C.P., Cunniff, K., Goff, S.C. & Orkin, S.H. (1996) Arrested development of embryonic red cell precursors in mouse embryos lacking transcription factor GATA-1. Proc. Natl. Acad. Sci. USA 93, 12355-12358.
2. Gregory, R.C., Taxman, D.J., Seshasayee, D., Kensinger, M.H., Bieker, J.J. & Wojchowski, D.M. (1996) Functional interaction of GATA1 with erythroid Krüppel-like factor and Sp1 at defined erythroid promoters. Blood 87, 1793-1801.
3. Harigae, H., Takahashi, S., Suwabe, N., et al. (1998) Differential roles of GATA-1 and GATA-2 in growth and differentiation of mast cells. Genes Cells 3, 39-50.
4. Ito, E., Toki, T., Ishihara, H., et al. (1993) Erythroid transcription factor GATA-1 is abundantly transcribed in mouse testis. Nature 362, 466-468.
5. Kobayashi, M., Nishikawa, K. & Yamamoto, M. (2001) Hematopoietic regulatory domain of gata1 gene is positively regulated by GATA1 protein in zebrafish embryos. Development 128, 2341-2350.
6. Merika, M. & Orkin, S.H. (1995) Functional synergy and physical interactions of the erythroid transcription factor GATA-1 with the Krüppel family proteins Sp1 & EKLF. Mol. Cell. Biol. 15, 2437-2347.
7. Nicolis, S., Bertini, C., Ronchi, A., et al. (1991) An erythroid specific enhancer upstream to the gene encoding the cell-type specific transcription factor GATA-1. Nucl. Acids Res. 19, 5285-5291.
8. Nishimura, S., Takahashi, S., Kuroha, T., et al. (2000) A GATA box in the GATA-1 gene hematopoietic enhancer is a critical element in the network of GATA factors and sites that regulate this gene. Mol. Cell. Biol. 20, 713-723.
9. Onodera, K., Takahashi, S., Nishimura, S., et al. (1997) GATA-1 transcription is controlled by distinct regulatory mechanisms during primitive and definitive erythropoiesis. Proc. Natl. Acad. Sci. USA 94, 4487-4492.
10. Ronchi, A., Ciro, M., Cairns, L., et al. (1997) Molecular heterogeneity of regulatory elements of the mouse GATA-1 gene. Genes Funct. 1, 245 - 258.
11. Seshasayee, D., Geiger, J.N., Gaines, P. & Wojchowski, D.M. (2000) Intron 1 elements promote erythroid-specific GATA-1 gene expression. J. Biol. Chem. 275, 22969-22977.
12. Shimizu, R., Takahashi, S., Ohneda, K., Engel, J.D. & Yamamoto, M. (2001) In vivo requirements for GATA-1 functional domains during primitive and definitive erythropoiesis. EMBO J. 20, 5250-5260.
13. Suwabe, N., Takahashi, S., Nakano, T. & Yamamoto, M. (1998) GATA-1 regulates growth and differentiation of definitive erythroid lineage cells during in vitro ES cell differentiation. Blood 92, 4108-4018.
14. Takahashi, S., Onodera, K., Motohashi, H., et al. (1997) Arrest in primitive erythroid cell development caused by promoter-specific disruption of the GATA-1 gene. J. Biol. Chem. 272, 12611-12615.
15. Takahashi, S., Shimizu, R., Suwabe, N., et al. (2000) GATA factor transgenes under GATA-1 locus control rescue germline GATA-1 mutant deficiencies. Blood 96, 910-916.
16. Tomotsune, D., Shoji, H., Wakamatsu, Y., Kondoh, H. & Takahashi, N. (1993) A mouse homologue of the Drosophila tumor-suppressor gene 1(2)gl controlled by Hox-C8 in vivo. Nature 365, 69-72.
17. Trainor, C.D., Omichinski, J.G., Vandergon, T.L., Gronenborn, A.M., Clore, G.M. & Felsenfeld, G. (1996) A palindromic regulatory site within vertebrate GATA-1 promoters requires both zinc fingers of the GATA-1 DNA-binding domain for high-affinity interaction. Mot. Cell. Biol. 16, 2238-2247.
18. Tsai, S.F., Strauss, E. & Orkin, S.H. (1991) Functional analysis & in vivo footprinting implicate the erythroid transcription factor GATA-1 as a positive regulator of its own promoter. Genes Dev. 5, 919-931.
19. Vyas, P., McDevitt, M.A., Cantor, A.B., Katz, S.G., Fujiwara, Y. & Orkin, S.H. (1999) Different sequence requirements for expression in erythroid & megakaryocytic cells within a regulatory element upstream of the GATA-1 gene. Development 126, 2799-2811.
20. Yamamoto, M., Ko, L.J., Leonard, M.W., Beug, H., Orkin, S.H. & Engel, J.D. (1990) Activity and tissue-specific expression of the transcription factor NF-E1 multigene family. Genes Dev. 4, 1650-1662.
21. Yamamoto, M., Takahashi, S., Onodera, K., Muraosa, Y. & Engel, J.D. (1997) Upstream and downstream of erythroid transcription factor GATA-1. Genes Cells 2, 107-115.