Can claudication be improved with medication?

Seminars in Vascular Surgery

Volumn 15, Issue 4, 2002, Pages 237-244

  Conners, Michael S ^a   Money, Samuel R ^a  

^a OCHSNER CLINIC FOUNDATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; AMINOPHYLLINE; ANTIFUNGAL AGENT; ARGININE; BERAPROST; BUFLOMEDIL; CALCIUM CHANNEL BLOCKING AGENT; CARNITINE; CHELATING AGENT; CILOSTAZOL; CLOPIDOGREL; ECRAPROST; EDETIC ACID; ERYTHROMYCIN; GINKGO BILOBA EXTRACT; KETANSERIN; METHYLXANTHINE DERIVATIVE; NAFTIDROFURYL; OMEPRAZOLE; PENTOXIFYLLINE; PHOSPHODIESTERASE INHIBITOR; PRODRUG; PROSTAGLANDIN E1 DERIVATIVE; SEROTONIN 2 ANTAGONIST; SEROTONIN UPTAKE INHIBITOR; THEOPHYLLINE; TICLOPIDINE; UNCLASSIFIED DRUG; VASODILATOR AGENT; VERAPAMIL;

ATHEROSCLEROSIS; CHELATION; CLINICAL TRIAL; DIARRHEA; DISEASE ASSOCIATION; DRUG EFFICACY; DRUG METABOLISM; ERYTHEMA; EXERCISE; GASTROINTESTINAL TOXICITY; GINKGO BILOBA; HEADACHE; HEART INFARCTION; HEART PALPITATION; HUMAN; INTERMITTENT CLAUDICATION; LIFESTYLE; META ANALYSIS; MORBIDITY; NAUSEA; PATIENT COMPLIANCE; PRIORITY JOURNAL; PRURITUS; REVIEW; STROKE; VERTIGO; WALKING;

EID: 0036909203     PISSN: 08957967     EISSN: None     Source Type: Journal    
DOI: 10.1053/svas.2002.36259     Document Type: Review

References (39)

1. Hiatt WR: Medical treatment of peripheral arterial disease and claudication. N Engl J Med 344:1608-1621, 2001
2. Goldhaber SZ, Manson JE, Stampfer MJ, et al: Low-dose aspirin and subsequent peripheral arterial surgery in the physician's health study. Lancet 340:143-145, 1992
3. Collaborative overview of randomized trials of antiplatelet therapy II: Maintenance of vascular graft or arterial patency by antiplatelet therapy. BMJ 308:159-168, 1994
4. CARPIE Steering Committee: A randomized, blinded, trial of clopidogrel versus aspirin in patients at risk of ischemic events (CARPIE). Lancet 348:1329-1339, 1996
5. Coffman JD: Vasodilator drugs in peripheral vascular disease. N Engl J Med 300:713-717, 1979
6. Bagger JP, Helligsoe P, Randsbaek F, et al: Effect of verapamil in intermittent claudication. Circulation 95:411-414, 1997
7. Porter JM, Culter BS, Lee BY, et al: Pentoxifylline efficacy in the treatment of intermittent claudication: Multicenter controlled double blind trial with objective assessment of chronic occlusive arterial disease patients. Am Heart J 104:66-72, 1982
8. Lingäirde F, Jelnes R, Björkman H, et al: Conservative drug treatment in patients with moderately severe chronic occlusive peripheral arterial disease. Circulation 80:1549-1556, 1989
9. Ernst E, Kollär L, Resch KL: Does pentoxifylline prolong the walking distance in exercised claudicants? A placebocontrolled double-blind trial. Angiology 42:121-125, 1992
10. Hood SC, Moher D, Barber GG: Management of intermittent claudication with pentoxifylline: Meta-analysis of randomized controlled trials. Can Med Assoc J 155:1053-1059, 1996
11. Girolami B, Bernardi E, Prins MH, et al: Treatment of intermittent claudication with physical training, smoking cessation, pentoxifylline or nafronyl: A meta-analysis. Arch Intern Med 159:337-345, 1999
12. Money SR, Herd JA, Isaacsohn JL, et al: Effect of cilostazol on walking distances in patients with intermittent claudication caused by peripheral vascular disease. J Vasc Surg 27:267-275, 1998
13. Takahashi S, Oida K, Fujiwara R, et al: Effect of cilostazol, a cyclic AMP phosphodiesterase inhibitor, on the proluferation of rat aortic smooth muscle cells in culture. J Cardiovasc Pharmacol 20:900-906, 1992
14. Beebe HG, Dawson DL, Cutler BS, et al: A new pharmacological treatment for intermittent claudication: Results of a randomized, multicenter trial. Arch Intern Med 159:2041-2050, 1999
15. Dawson DL, Cutler BS, Meissner MH, et al: Cilostazol has beneficial effects in treatment of intermittent claudication. Circulation 98:678-686, 1998
16. Packer M, Carver JR, Rodeheffer RJ, et al: Effect of oral milrinone on mortality in severe chronic heart failure. The PROMISE study research group. N Eng J Med 325:1468-1475, 1991
17. Fagher B, Persson S, Persson G, et al: Blood viscosity during long-term treatment with ticlopidine in patients with intermittent claudication. A double-blind study. Angiology 44:300-306, 1993
18. Balsano F, Coccheri S, Libretti A, et al: Ticlopidine in the treatment of intermittent claudication: A 21-month doubleblind trial. J Lab Clin Med 114:84-91, 1989
19. Arcan JC, Blanchard J, Boissel JP, et al: Multicenter double-blind study of ticlopidine in the treatment of intermittent claudication and the prevention of its complications. Angiology 39:802-811, 1988
20. Fagher B: Long-term effects of ticlopidine on lower limb blood flow, ankle/brachial index and symptoms in peripheral arteriosclerosis. A double-blind study. Angiology 45:777-788, 1994
21. Haynes RB, Sandler RS, Larson EB, et al: A critical appraisal of ticlopidine, a new antiplatelet agent. Arch Intern Med 152:1376-1380, 1992
22. Belch JJF, Bell PRF, Creissen D, et al: Randomized, double blind, placebo-controlled study evaluating the efficacy and safety of AS-013, a prostaglandin El prodrug, in patients with intermittent claudication. Circulation 95:2298-2302, 1997
23. Diehm C, Balzer K, Bisler H, et al: Efficacy of a new prostaglandin El regimen in outpatients with severe intermittent claudication: Results of a multicenter placebo-controlled double blind trial. J Vasc Surg 25:537-544, 1997
24. Lièvre M, Morand S, Besse B, et al: Oral Beraprost sodium, a prostaglandin 12 analogue, for intermittent claudication. Circulation 102:426-431, 2000
25. Trübestein G, Böhme H, Heidrich H, et al: Naftidrofuryl in chronic arterial disease. Results of a controlled multicenter study. Angiology 35:500-505, 1984
26. Adhoute G, Bacourt F, Barral M, et al: Naftidrofuryl in chronic arterial disease results of a six month controlled multicenter study using Naftidrofuryl tablets 200 mg. Angiology 37:160-169, 1986
27. Brevetti G, Chiariello M, Ferulano G, et al: Increases in walking distance in patients with peripheral vascular disease treated with L-carnitine: A double-blind, cross-over study. Circulation 77:767-773, 1988
28. Brevetti G, Perna S, Sabba C, et al: Propionyl-L-carnitine in intermittent claudication: Double-blind, placebo-controlled, dose titration, multicenter study. J Am Coll Cardiol 26:1411-1416, 1995
29. Brevetti G, Perna S, Sabba C, et al: Superiority of L-propionyl carnitine to L-carnitine in improving walking capacity in patients with peripheral vascular disease. An acute, intravenous, double-blind, cross-over study. Eur Heart J 13:251-255, 1992
30. Brevetti G, Perna S, Sabba C, et al: Effect of propionylL-carnitine on quality of life in intermittent claudication. Am J Cardiol 79:777-780, 1997
31. Olszewer E, Carter JP: EDTA chelation therapy in chronic degenerative disease. Med Hyp 28:41-49, 1988
32. Guldager B, Jelnes R, Jorgensen SJ, et al: EDTA treatment of intermittent claudication-a double-blind, placebo controlled study. J Intern Med 231:261-267, 1992
33. van Rij AM, Solomon C, Packer SGK, et al: Chelation therapy for intermittent claudication. A double-blind, randomized, controlled trial. Circulation 90:1194-1199, 1994
34. Ernst E: Chelation therapy for peripheral arterial occlusive disease. Circulation 96:1031-1033, 1997
35. Chappell LT, Miranda R, Hancke C, et al: EDTA chelation treatment for peripheral vascular disease. J Intern Med 237:429-434, 1995
36. Böger RH, Bode-Böger SM, Thiele W, et al: Restoring vascular nitric oxide formation by L-arginine improves the symptoms of intermittent claudication in patients with peripheral arterial occlusive disease. J Am Coll Cardiol 32:1336-1341, 1998
37. Pittler MH, Ernst E: Ginkgo biloba extract for the treatment of intermittent claudication: A meta-analysis of randomized trials. Am J Med 108:276-281, 2000
38. Trübestein G, Balzer K, Bisler H, et al: Buflomedil in arterial occlusive disease: Results of a controlled multicenter study. Angiology 35:500-505, 1984
39. PACK Claudication Substudy Investigators: Randomized placebo-controlled, double-blind trial of ketanserin in claudicants. Circulation 80:1544-1548, 1989