Two flavones from Scutellaria baicalensis Georgi and their binding affinities to the benzodiazepine site of the GABAA receptor complex

Pharmazie

Volumn 57, Issue 12, 2002, Pages 857-858

  Wang, Hongyan ^a,b,c   Hui, Kwok Min ^b   Xu, Suixu ^a   Chen, Yingjie ^a   Wong, J Tze Fei ^b   Xue, Hong ^b  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Hong Kong)

^c NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; 5,7,2' TRIHYDROXY 6,8 DIMETHOXYFLAVONE; 6,2' DIHYDROXY 5,7,8,6' TETRAMETHOXYFLAVONE; BENZODIAZEPINE; FLAVONE DERIVATIVE; SCUTELLARIA BAICALENSIS EXTRACT; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING SITE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; LIGAND BINDING; NONHUMAN; PLANT ROOT; RAT; STRUCTURE ANALYSIS;

ANIMALS; BINDING, COMPETITIVE; BRAIN; DIMETHYL SULFOXIDE; FLAVONOIDS; FLUNITRAZEPAM; GABA MODULATORS; MAGNETIC RESONANCE SPECTROSCOPY; PLANT ROOTS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA-A; SCUTELLARIA;

EID: 0036907849     PISSN: 00317144     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (5)

1. Hui, K. M.; Wang, X. H.; Xue, H.: Planta Med. 66, 91 (2000)
2. Horie, T.; Ohtsuru, Y.; Shibata, K.; Yamashita K.; Tsukayama, M.; Kawamura, Y.: Phytochemistry 47, 865 (1998)
3. Iinuma, M.; Matsuura, S.; Kusuda K.: Chem. Pharm. Bull. 28, 708 (1980)
4. Yoko, M.; Yukinori, M.; Tomimori Tsuyoshi, T.: Yakugaku Zasshi 114, 775 (1994)
5. Vogel, H. G.; Vogel, W. H.: In: Drug Discovery and Evaluation: Pharmacology Assay, p. 218. Springer, New York 1997