The chemokine receptor CCR6 identifies interferon-γ expressing T cells and is decreased in atopic dermatitis as compared with psoriasis

Journal of Investigative Dermatology

Volumn 119, Issue 6, 2002, Pages 1463-1464

  Leung, Donald Y M ^a,b   Ong, Peck Y ^a  

^a NATIONAL JEWISH MEDICAL AND RESEARCH CENTER   (United States)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD3 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; CHEMOKINE RECEPTOR CCR6; GAMMA INTERFERON; IMMUNOGLOBULIN E; INTERLEUKIN 13; INTERLEUKIN 4; MACROPHAGE INFLAMMATORY PROTEIN 3ALPHA;

ALLERGIC RHINITIS; ASTHMA; ATOPIC DERMATITIS; CLINICAL ARTICLE; CONTROLLED STUDY; DOWN REGULATION; EOSINOPHIL; FLOW CYTOMETRY; HUMAN; IMMUNOGLOBULIN PRODUCTION; INFLAMMATORY CELL; LETTER; LEUKOCYTE; MEMORY CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PSORIASIS; REGULATORY MECHANISM; T LYMPHOCYTE; TH2 CELL;

EID: 0036907174     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1747.2002.19624.x     Document Type: Letter

References (15)

1. Akdis CA, Akdis M, Simon D, et al: T cells and T cell-derived cytokines as pathogenic factors in the nonallergic form of atopic dermatitis. J Invest Dermatol 113:628-634, 1999
2. Bochner BS: Road signs guiding leukocytes along the inflammation superhighway. J Allergy Clin Immunol 106:817-828, 2000
3. Greaves DR, Wang W, Dairaghi DJ, et al: CCR6, a CC chemokine receptor that interacts with macrophage inflammatory protein 3alpha and is highly expressed in human dendritic cells. J Exp Med 186:837-844, 1997
4. Grewe M, Gyufko K, Schopf E, Krutmann J: Lesional expression of interferon-gamma in atopic eczema. Lancet 343:25-26, 1994
5. Habu Y, Seki S, Takayama E, et al: The mechanism of a defective IFN-gamma response to bacterial toxins in an atopic dermatitis model, NC/Nga mice, and the therapeutic effect of IFN-gamma, IL-12, or IL-18 on dermatitis. J Immunol 166:5439-5447, 2001
6. Hamid Q, Boguniewicz M, Leung DY: Differential in situ cytokine gene expression in acute versus chronic atopic dermatitis. J Clin Invest 94:870-876, 1994
7. Hamid Q, Naseer T, Minshall EM, Song YL, Boguniewicz M, Leung DY: In vivo expression of IL-12 and IL-13 in atopic dermatitis. J Allergy Clin Immunol 98:225-231, 1996
8. Homey B, Dieu-Nosjean MC, Wiesenborn A, et al: Up-regulation of macrophage inflammatory protein-3 alpha/CCL20 and CC chemokine receptor 6 in psoriasis. J Immunol 164:6621-6632, 2000
9. Jujo K, Renz H, Abe J, Gelfand EW, Leung DY: Decreased interferon gamma and increased interleukin-4 production in atopic dermatitis promotes IgE synthesis. J Allergy Clin Immunol 90:323-331, 1992
10. Leung DY: Atopic dermatitis new insights and opportunities for therapeutic intervention. J Allergy Clin Immunol 105:860-876, 2000
11. Lukacs NW, Prosser DM, Wiekowski M, Lira SA, Cook DN: Requirement for the chemokine receptor CCR6 in allergic pulmonary inflammation. J Exp Med 194:551-555, 2001
12. + T lymphocytes are increased in peripheral blood and lesional skin from patients with atopic dermatitis. J Allergy Clin Immunol 107:353-358, 2001
13. Nakayama T, Fujisawa R, Yamada H, et al: Inducible expression of a CC chemokine liver- and activation-regulated chemokine (LARC)/macrophage inflammatory protein (MIP)-3 alpha/CCL20 by epidermal keratinocytes and its role in atopic dermatitis. Int Immunol 13:95-103, 2001
14. Rossi DL, Vicari AP, Franz-Bacon K, McClanahan TK, Zlotnik A: Identification through bioinformatics of two new macrophage proinflammatory human chemokines: MIP-3alpha and MIP-3beta. J Immunol 158:1033-1036, 1997
15. Schlaak JF, Buslau M, Jochum W, et al: T cells involved in psoriasis vulgaris belong to the Th1 subset. J Invest Dermatol 102:145-149, 1994