Progressive hepatic fibrosis in healthy carriers of hepatitis C virus with a transaminase breakthrough

Journal of Viral Hepatitis

Volumn 9, Issue 1, 2002, Pages 71-74

  Rumi, Maria Grazia ^a,b   De Filippi, F ^a   Donato, M F ^a   Del Ninno, E ^a   Colombo, M ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b NONE   (Italy)

Author keywords

Alanine aminotransferase flares; Asymptomatic carriers; Fibrosis; Genotype 2c; Hepatitis C virus

Indexed keywords

ALPHA2B INTERFERON; AMINOTRANSFERASE; RIBAVIRIN; VIRUS RNA;

ADULT; ARTICLE; CASE REPORT; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE COURSE; ENZYME BLOOD LEVEL; FEMALE; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; HUMAN TISSUE; INFECTION RISK; LABORATORY TEST; LIVER BIOPSY; LIVER FIBROSIS; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; VIRUS CARRIER;

ADULT; ALANINE TRANSAMINASE; CARRIER STATE; DISEASE PROGRESSION; FEMALE; HEPACIVIRUS; HEPATITIS C, CHRONIC; HUMANS; LIVER CIRRHOSIS; MALE;

EID: 0036905695     PISSN: 13520504     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2893.2002.00328.x     Document Type: Article

References (25)

1. Alberti A, Chemello L, Benvegnù L. Natural history of hepatitis C. J Hepatol 1999; 31 (suppl): 17-24.
2. Poynard T, Bedossa P, Opolon P. Natural history of fibrosis progression in patients with chronic hepatitis C. Lancet 1997; 349: 825-832.
3. Dienes HP, Drebber U, von Both I. Liver biopsy in hepatitis C. J Hepatol 1999; 31 (suppl. 1): 43-46.
4. Pagliaro L, Peri V, Linea C, Cammaa C, Giunta M, Magrin S. Natural history of chronic hepatitis C. Ital J Gastroenterol Hepatol 1999; 31: 28-44.
5. Gordon SC, Fang JWS, Silverman AL, McHutchison JG, Albrecht JK. The significance of baseline serum alanine aminotransferase on pre-treatment disease characteristics and response to anti-viral therapy in chronic hepatitis C. Hepatology 2000; 32: 400-404.
6. Persico M, Persico E, Suozzo R et al. Natural history of hepatitis C virus carriers with persistently normal aminotransferase levels. Gastroenterology 2000; 118: 760-764.
7. Hayashi J, Furusyo N, Ariyama I, Sawayama Y, Etoh Y, Kashiwagi S. A relationship between the evolution of hepatitis C variants, liver damage, and hepatocellular carcinoma in patients with hepatitis C viremia. J Infect Dis 2000; 181: 1523-1527.
8. Silini E, Bono F, Cividini A et al. Differential distribution of hepatitis C virus genotypes in patients with and without liver function abnormalities. Hepatology 1995; 21: 285-290.
9. Alberti A, Morsica G, Chemello L et al. Hepatitis C viremia and liver disease in symptom-free individuals with anti-HCV. Lancet 1992; 340: 697-698.
10. Brillanti S, Foli M, Gaiani S, Masci C, Miglioli M, Barbara L. Persistent hepatitis C viremia without liver disease. Lancet 1993; 341: 464-465.
11. Naito M, Hayashi N, Hagiwara H et al. Serum hepatitis C virus RNA quantity and histological features of hepatitis C virus carriers with persistently normal ALT levels. Hepatology 1994; 19: 871-875.
12. Shindo M, Arai K, Sokawa Y, Okuno T. The virological and histological states of anti-hepatitis C virus-positive subjects with normal liver biochemical values. Hepatology 1995; 22: 418-425.
13. Mathurin P, Moussalli J, Cadranel JF et al. Slow progression rate of fibrosis in hepatitis C virus patients with persistently normal alanine transaminase activity. Hepatology 1998; 27: 868-872.
14. Nousbaum JB, Pol S, Nalpas B et al. Hepatitis C virus type 1b (II) infection in France and Italy. Ann Intern Med 1995; 122: 161-168.
15. Pol S, Fontaine H, Carnot F et al. Predictive factors for development of cirrhosis in parenterally acquired chronic hepatitis C: A comparison between immunocompetent and immunocompromised patients. J Hepatol 1998; 29: 12-19.
16. Hoofnagle JH. Hepatitis C: The clinical spectrum of disease. J Hepatol 1997; 26: 15S-20S.
17. Healey CJ, Chapman RWG, Fleming KA. Liver histology in hepatitis C infection. A comparison between patients with persistently normal or abnormal transaminases. Gut 1995; 37: 274-278.
18. Haber MM, West AB, Haber AD, Reuben A. Relationship of aminotransferases to liver histological status in chronic hepatitis C. Am J Gastroenterol 1995; 90: 1250-1257.
19. Pontisso P, Bellati G, Brunetto M et al. Hepatitis C virus RNA profiles in chronically infected individuals: Do they relate to disease activity? Hepatology 1999; 29: 585-589.
20. Rehermann B. Interaction between the hepatitis C virus and the immune system. Semin Liv Dis 2000; 20: 127-141.
21. Tassopoulos NC. Treatment of patients with chronic hepatitis C and normal ALT levels. J Hepatol 1999; 31 (suppl. 1): 193-196.
22. Marcellin P. Hepatitis C: The clinical spectrum of the disease. J Hepatol 1999; 31 (suppl. 1): 9-16.
23. Silini E, Battelli R, Asti M et al. Hepatitis C virus genotypes and risk of hepatocellular carcinoma in cirrhosis: A case-control study. Gastroenterology 1996; 111: 199-205.
24. Romeo R, Colombo M, Rumi MG et al. Lack of association between type of hepatitis C virus, serum load and severity of liver disease. J Vir Hep 1996; 3: 183-190.
25. Prati D, Capelli C, Zanella A et al. Influence of different hepatitis C virus genotype on the course of asymptomatic hepatitis C virus infection. Gastroenterology 1996; 110: 178-183.