Effects of supratherapeutic doses of ebastine and terfenadine on the QT interval [5]

British Journal of Clinical Pharmacology

Volumn 54, Issue 6, 2002, Pages 682-683

  Malik, Marek ^a  

^a ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EBASTINE; PLACEBO; TERFENADINE;

ACCURACY; ANALYTICAL ERROR; CALCULATION; CLINICAL PRACTICE; CORRELATION COEFFICIENT; DRUG EFFECT; DRUG MEGADOSE; ELECTROCARDIOGRAM; HEART RATE; HEART RATE VARIABILITY; HUMAN; LETTER; MEDICAL DECISION MAKING; METHODOLOGY; PARAMETER; PRIORITY JOURNAL; QT INTERVAL; RR INTERVAL; STATISTICAL SIGNIFICANCE;

BUTYROPHENONES; ELECTROCARDIOGRAPHY; HEART RATE; HISTAMINE H1 ANTAGONISTS; HUMANS; PIPERIDINES; TERFENADINE;

EID: 0036904543     PISSN: 03065251     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.0306-5251.2002.01661.x     Document Type: Letter

References (5)

1. Gillen MS, Miller B, Chaikin P, Morganroth J. Effects of supratherapeutic doses of ebastine and terfenadine on the QT interval. Br J Clin Pharmacol 2001; 52: 201-204.
2. Batchvarov VN, Ghuran A, Smetana P, Hnatkova K, Harries M, Dilaveris P, Camm AJ, Malik M. QT-RR relationship in healthy subjects exhibits substantial intersubject variability and high intrasubject stability. Am J Physiol 2002; 282: H2356-H2363.
3. Malik M, Camm AJ. Evaluation of drug-induced QT interval prolongation: Implications for drug approval and labelling. Drug Safety 2001; 24: 323-351.
4. Malik M, Färbom P, Batchvarov V, Hnatkova K, Camm AJ. The relationship between QT and RR intervals is highly individual among healthy subjects - Implications for heart rate correction of the QT Interval. Heart, 2002; 87: 220-228.
5. Malik M. Problems of heart rate correction in assessment of drug-induced QT interval prolongation. J Cardiovasc Electrophysiol 2001; 12: 411-420.