Effects of feeding aspirin and supplemental vitamin E on plasma concentrations of 3-methylindole, 3-methyleneindolenine-adduct concentration in blood and pulmonary tissues, lung lesions, and growth performance in feedlot cattle

American Journal of Veterinary Research

Volumn 63, Issue 12, 2002, Pages 1641-1647

  Loneragan, Guy H ^a   Morley, Paul S ^a   Wagner, John J ^b   Mason, Gary L ^a   Yost, Garold S ^c   Thoren, Mike A ^d   Wittum, Thomas E ^e   Bray, Tammy M ^e  

^a Department of Environmental and Radiological Health Sciences   (United States)

^b Continental Beef Research ^*  (United States)

^c UNIVERSITY OF UTAH   (United States)

^d ContiBeef LCC ^*  (United States)

^e OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 METHYLENEINDOLENINE; ACETYLSALICYLIC ACID; ALPHA TOCOPHEROL; BOVISHIELD4; DECTOMEX; DORAMECTIN; ESTRADIOL; FORTRESS CD; GROWTH PROMOTOR; INDOLE DERIVATIVE; PROTEIN; REVALOR S; SKATOLE; TOXOID; TRENBOLONE ACETATE; UNCLASSIFIED DRUG; VIRUS VACCINE;

ANIMAL HOUSING; ARTICLE; BEEF CATTLE; BLOOD LEVEL; CONTROLLED STUDY; DRUG EFFECT; FACTORIAL ANALYSIS; FEEDING; FOOD INTAKE; GROWTH CURVE; LUNG INJURY; LUNG PARENCHYMA; MALE; NONHUMAN; TISSUE LEVEL; WEIGHT GAIN;

ANIMALIA; BOS TAURUS;

EID: 0036902229     PISSN: 00029645     EISSN: None     Source Type: Journal    
DOI: 10.2460/ajvr.2002.63.1641     Document Type: Article

References (33)

1. Yokoyama MT, Carlson JR, Dickinson EO. Ruminal and plasma concentrations of 3-methylindole associated with tryptophan-induced pulmonary edema and emphysema in cattle. Am J Vet Res 1975;36:1349-1352.
2. Carlson JR, Dickinson EO, Yokoyama MT, et al. Pulmonary edema and emphysema in cattle after intraruminal and intravenous administration of 3-methylindole. Am J Vet Res 1975;36:1341-1347.
3. Hammond AC, Glenn BP, Huntington GB, et al. Site of 3-methylindole and indole absorption in steers after ruminal administration of L-tryptophan. Am J Vet Res 1984;45:171-174.
4. Bray TM, Emmerson KS. Putative mechanisms of toxicity of 3-methylindole: from free radical to pneumotoxicosis. Annu Rev Pharmacol Toxicol 1994;34:91-115.
5. Yost GS. Mechanisms of 3-methylindole pneumotoxicity. Chem Res Toxicol 1989;2:273-279.
6. Wang H, Lanza DL, Yost GS. Cloning and expression of CYP2F3, a cytochrome P450 that bicactivates the selective pneumotoxins 3-methylindole and naphthalene. Arch Biochem Biophys 1998;349:329-340.
7. Thornton-Manning J, Appleton ML, Gonzalez FJ, et al. Metabolism of 3-methylindole by vaccinia-expressed P450 enzymes: correlation of 3-methyleneindolenine formation and protein-binding. J Pharmacol Exp Ther 1996;276:21-29.
8. Skiles GL, Yost GS. Mechanistic studies on the cytochrome P450-catalyzed dehydrogenation of 3-methylindole. Chem Res Toxicol 1996;9:291-297.
9. Lanza DL, Yost GS. Selective dehydrogenation/oxygenation of 3-methylindole by cytochrome p450 enzymes. Drug Metab Dispos 2001;29:950-953.
10. Yost GS. Selected nontherapeutic agents. In: Roth RA, ed. Toxicology of the respiratory system. New York: Elsevier Science, 1997;591-610.
11. Kaster JK, Yost GS. Production and characterization of specific antibodies: utilization to predict organ- and species-selective pneumotoxicity of 3-methylindole. Toxicol Appl Pharmacol 1997;143:324-337.
12. Formosa PJ, Bray TM, Kubow S. Metabolism of 3-methylindole by prostaglandin H synthase in ram seminal vesicles. Can J Physiol Pharmacol 1988;66:1524-1530.
13. Kubow S, Janzen EG, Bray TM. Spin-trapping of free radicals formed during in vitro and in vivo metabolism of 3-methylindole. J Biol Chem 1984;259:4447-4451.
14. Kubow S, Dubose CM Jr, Janzen EG, et al. The spin-trapping of enzymatically and chemically catalyzed free radicals from indolic compounds. Biochem Biophys Res Commun 1983;114:168-174.
15. Formosa PJ, Bray TM. Evidence for metabolism of 3-methylindole by prostaglandin H synthase and mixed-function oxidases in goat lung and liver microsomes. Biochem Pharmacol 1988;37:4359-4366.
16. Yokoyama MT, Carlson JR, Holdeman LV. Isolation and characteristics of a skatole-producing Lactobacillus sp. from the bovine rumen. Appl Environ Microbiol 1977;34:837-842.
17. Loneragan GH, Morley PS, Wagner JJ, et al. Time-dependent changes in plasma concentrations of 3-methylindole and blood concentrations of 3-methyleneindolenine-adduct in feedlot cattle. Am J Vet Res 2002;63:591-597.
18. Bingham HR, Wittum TE, Morley PS, et al. Evaluation of the ability of orally administered aspirin to mitigate effects of 3-methylindole in feedlot cattle. Am J Vet Res 2000;61:1209-1213.
19. Bingham HR, Morley PS, Wittum TE, et al. Effects of 3-methylindole production and immunity against bovine respiratory syncytial virus on development of respiratory tract disease and rate of gain of feedlot cattle. Am J Vet Res 2000;61:1309-1314.
20. Acton KS, Boermans HJ, Bray TM. The role of prostaglandin H synthase in 3-methylindole-induced pneumotoxicity in goat. Comp Biochem Physiol C 1992;101:101-108.
21. Mortensen AB, Sorensen SE. Relationship between boar taint skatole determined with a new analysis method, in Proceedings. 30th Eur Meet Meat Res Workers 1984;394-395.
22. Littell RC, Henry PR, Ammerman CB. Statistical analysis of repeated measures data using SAS procedures. J Anim Sci 1998;76:1216-1231.
23. Chew BP. Antioxidant vitamins affect food animal immunity and health. J Nutr 1995;125:1804S-1808S.
24. National Research Council. Subcommittee on Beef Cattle Nutrition. Nutrient requirements of beef cattle. 7th ed. Washington, DC: National Academy Press, 1996.
25. Bingham HR, Morley PS, Wittum TE, et al. Synergistic effects of concurrent challenge with bovine respiratory syncytial virus and 3-methylindole in calves. Am J Vet Res 1999;60:563-570.
26. Wittum TE, Woollen NE, Perino LJ, et al. Relationships among treatment for respiratory tract disease, pulmonary lesions evident at slaughter, and rate of weight gain in feedlot cattle. J Am Vet Med Assoc 1996;209:814-818.
27. Gardner BA, Dolezal HG, Bryant LK, et al. Health of finishing steers: effects on performance, carcass traits, and meat tenderness. J Anim Sci 1999;77:3168-3175.
28. Lanza DL, Code E, Crespi CL, et al. Specific dehydrogenation of 3-methylindole and epoxidation of naphthalene by recombinant human CYP2F1 expressed in lymphoblastoid cells. Drug Metab Dispos 1999;27:798-803.
29. Loneragan GH, Gould DH, Mason GL, et al. Association of 3-methyleneindolenine, a toxic metabolite of 3-methylindole, with acute interstitial pneumonia in feedlot cattle. Am J Vet Res 2001;62: 1525-1530.
30. Acton KS, Bray TM, Boermans HJ. Effect of 3-methylindole on the plasma and lung concentrations of prostaglandins and thromboxane B2 in goats. Comp Biochem Physiol A 1989;94:677-681.
31. Njeru CA, McDowell LR, Shireman RM, et al. Assessment of vitamin E nutritional status in yearling beef heifers. J Anim Sci 1995; 73:1440-1448.
32. Hidiroglou M, Batra TR, Zhao X. Bioavailability of vitamin E compounds and the effect of supplementation on release of superoxide and hydrogen peroxide by bovine neutrophils. J Dairy Sci 1997;80:187-193.
33. Sanders SK, Morgan JB, Wulf DM, et al. Vitamin E supplementation of cattle and shelf-life of beef for the Japanese market. J Anim Sci 1997;75:2634-2640.