Flufenamic acid blocks depolarizing afterpotentials and phasic firing in rat supraoptic neurones

Journal of Physiology

Volumn 545, Issue 2, 2002, Pages 537-542

  Ghamari Langroudi, Masoud ^a   Bourque, Charles W ^a  

^a MONTREAL GENERAL HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; CATION; CATION CHANNEL; DIMETHYL SULFOXIDE; FLUFENAMIC ACID; POTASSIUM ION; SOLVENT; CALCIUM DEPENDENT NON SELECTIVE CATION CHANNEL; UNCLASSIFIED DRUG;

ACTION POTENTIAL; AFTERDISCHARGE; AMPLITUDE MODULATION; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CALCIUM TRANSPORT; CATION TRANSPORT; CONTROLLED STUDY; EVOKED RESPONSE; EXPLANT; FREQUENCY MODULATION; GIANT CELL; HYPOTHALAMUS; IC 50; INTRACELLULAR RECORDING; MALE; MEMBRANE CHANNEL; NERVE CELL MEMBRANE CONDUCTANCE; NERVE CELL MEMBRANE POTENTIAL; NERVE CELL MEMBRANE STEADY POTENTIAL; NEUROSECRETORY CELL; NEUROTRANSMISSION; NONHUMAN; PERFUSION AND SUPERFUSION; POTASSIUM CURRENT; PRIORITY JOURNAL; RAT; SPIKE; SUPRAOPTIC NUCLEUS; SYNAPTIC POTENTIAL; DEPOLARIZING AFTERPOTENTIAL; DOSE RESPONSE; EXCITATORY POSTSYNAPTIC POTENTIAL; HIPPOCAMPUS; IC50; INHIBITORY POSTSYNAPTIC POTENTIAL; NERVE CELL; NERVE CELL EXCITABILITY; PHASIC FIRING; SPIKE THRESHOLD; SUPRAOPTIC NEURON; SYNAPTIC POTENTIAL AMPLITUDE; SYNAPTIC POTENTIAL FREQUENCY;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CALCIUM; ELECTRIC STIMULATION; ELECTROPHYSIOLOGY; FLUFENAMIC ACID; ION CHANNELS; MALE; MEMBRANE POTENTIALS; MICROELECTRODES; NEURONS; PATCH-CLAMP TECHNIQUES; PITUITARY GLAND, POSTERIOR; RATS; RATS, LONG-EVANS; SUPRAOPTIC NUCLEUS; SYNAPTIC TRANSMISSION;

EID: 0036902089     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1113/jphysiol.2002.033589     Document Type: Article

References (30)

1. ANDREW, R. D. (1987). Endogenous bursting by rat supraoptic neuroendocrine cells is calcium dependent. Journal of Physiology 384, 451-465.
2. ANDREW, R. D. & DUDEK, F. E. (1984). Analysis of intracellularly recorded phasic bursting by mammalian neuroendocrine cells. Journal of Neurophysiology 51, 552-566.
3. ARMSTRONG, W. E., SMITH, B. N. & TIAN, M. (1994). Electrophysiological characteristics of immunochemically identified rat oxytocin and vasopressin neurones in vitro. Journal of Physiology 475, 115-128.
4. BOURQUE, C. W. (1986). Calcium-dependent spike after-current induces burst firing in magnocellular neurosecretory cells. Neuroscience Letters 70, 204-209.
5. BOURQUE, C. W. & BROWN, D. A. (1987). Apamin and d-tubocurarine block the after-hyperpolarization of rat supraopic neurosecretory neurons. Neuroscience Letters 82, 185-190.
6. BRIMBLE, M. J. & DYBALL, R. E. J. (1977). Characterization of the responses of oxytocin- and vasopressin-secreting neurones in the supraoptic nucleus to osmotic stimulation. Journal of Physiology 271, 253-271.
7. BROWN, C. H., GHAMARI-LANGROUDI, M., LENG, M. & BOURQUE, C. W. (1999). κ-Opioid receptor activation inhibits post-spike depolarizing after-potentials in rat supraoptic nucleus neurones in vitro. Journal of Neuroendocrinology 11, 825-828.
8. DUTTON, D. A. & DYBALL, R. E. J. (1979). Phasic firing enhances vasopressin release from the rat neurohypophysis. Journal of Physiology 290, 433-440.
9. - channels in ramification of murine microglia. Journal of Neuroscience 18, 7127-7137.
10. GHAMARI-LANGROUDI, M. & BOURQUE, C. W. (1998). Caesium blocks depolarizing after-potentials and phasic firing in rat supraoptic neurones. Journal of Physiology 510, 165-175.
11. GHAMARI-LANGROUDI, M. & BOURQUE, C. W. (2001). Ionic basis of the caesium-induced depolarisation in rat supraoptic nucleus neurones. Journal of Physiology 536, 797-808.
12. GREFFRATH, W., MARTIN, E., REUSS, S. & BOEHMER, G. (1998). Components of after-hyperpolarization in magnocellular neurones of the rat supraoptic nucleus in vitro. Journal of Physiology 513, 493-506.
13. 2+ -activated nonselective cation channel during dedifferentiation of cultured rat ventricular cardiomyocytes. Journal of Membrane Biology 188, 127-135.
14. HARKS, E. G. A., DE ROOS, A. D. G., PETERS, P. H. J., DE HAAN, L. H., BROUWER, A., YPEY, D. L., VAN ZOELEN, E. J. J. & THEUVENET, A. P. R. (2001). Fenamates: A novel class of reversible gap junction blockers. Journal of Pharmacology and Experimental Therapeutics 298, 1033-1041.
15. HARRIS, M. C., DREIFUSS, J. J. & LEGROS, J. J. (1975). Excitation of phasically-firing supraoptic neurones during vasopressin release. Nature 258, 80-82.
16. HATTON, G. I. & LI, Z. (1998). Mechanisms of neuroendocrine cell excitability. Advances in Experimental Medicine and Biology 449, 79-95.
17. JUNG, H. -Y., STAFF, N. P. & SPRUSTON, N. (2001). Action potential bursting in subicular pyramidal neurons is driven by a calcium tail current. Journal of Neuroscience, 21, 3312-3321.
18. + current in rat supraoptic neurones in vitro. Journal of Physiology 494, 389-398.
19. 28k: role in determining intrinsically generated firing patterns in rat supraoptic neurones. Journal of Physiology 488, 601-608.
20. 2+ release from internal stores: role in generating depolarizing after-potentials in rat supraoptic neurones. Journal of Physiology 498, 239-250.
21. + conductances generate depolarizing after-potentials in rat supraoptic nucleus neurones. Journal of Physiology 505, 95-106.
22. 2+ from different sources in mouse sympathetic neurones. Journal of Physiology 527, 249-264.
23. MORISSET, V. & NAGY, F. (1999). Ionic basis for plateau potentials in deep dorsal horn neurons of the rat spinal cord. Journal of Neuroscience 19, 7309-7316.
24. OUELLET, M. & PERCIVAL, M. D. (1995). Effect of inhibitor time-dependency on selectivity towards cyclooxygenase isoforms. Biochemical Journal 306, 247-251.
25. PARTRIDGE L. D. & SWANDULLA, D. (1988). Calcium-activated non-specific cation channels. Trends in Neurosciences 11, 69-72.
26. PARTRIDGE, L. D. & VALENZUELA, C. F. (2000). Block of hippocampal CAN channels by flufenamate. Brain Research 867, 143-148.
27. 2+-activated non-selective cation channels in rat hippocampal neurones in vitro. Journal of Physiology 521, 617-627.
28. RENAUD, L. P. & BOURQUE, C. W. (1991). Neurophysiology and neuropharmacology of hypothalamic magnocellular neurons secreting vasopressin and oxytocin. Progress in Neurobiology 36, 131-169.
29. WASHBURN, D. L., ANDERSON, J. W. & FERGUSON, A. V. (2000). A subthreshold persistent sodium current mediates bursting in rat subfornical organ neurones. Journal of Physiology 529, 359-371.
30. YANG, Q. Z. & HATTON, G. I. (1999). Nitric oxide via cGMP-dependent mechanism increases dye coupling and excitability of rat supraoptic nucleus neurons. Journal of Neuroscience 19, 4270-4279.