FISH, flexible joints and panic: Are anxiety disorders really expressions of instability in the human genome?

British Journal of Psychiatry

Volumn 181, Issue DEC., 2002, Pages 457-459

  Collier, David A ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AGORAPHOBIA; ANXIETY DISORDER; EDITORIAL; FLUORESCENCE IN SITU HYBRIDIZATION; GENE DUPLICATION; GENETICS; GENOME; HUMAN; JOINT LAXITY; PANIC; SOCIAL PHOBIA;

AGORAPHOBIA; ANXIETY DISORDERS; CHROMOSOMES, HUMAN, PAIR 15; GENE DUPLICATION; GENOME, HUMAN; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; JOINT INSTABILITY; LINKAGE (GENETICS); PANIC DISORDER;

EID: 0036900421     PISSN: 00071250     EISSN: None     Source Type: Journal    
DOI: 10.1192/bjp.181.6.457     Document Type: Editorial

References (18)

1. Bailey, J. A., Yavor, A. M., Viggiano, L., et al (2002) Human-specific duplication and mosaic transcripts: The recent paralogous structure of chromosome 22. American Journal of Human Genetics, 70, 83-100.
2. Bowater, R. P. & Wells, R. D. (2001) The intrinsically unstable life of DNA triplet repeats associated with human hereditary disorders. Progress in Nucleic Acid Research and Molecular Biology, 66, 159-202.
3. Csiszar, K. (2001) Lysyl oxidases: A novel multi-functional amine oxidase family. Progress in Nucleic Acid Research and Molecular Biology, 70, 1-32.
4. Emanuel, B. S. & Shaikh, T. H. (2001) Segmental duplications; an 'expanding' role in genomic instability and disease. Nature Reviews Genetics, 2, 791-800.
5. Funke, B., Epstein, J. A., Kochilas, L. K., et al (2001) Mice overexpressing genes from the 22q11 region deleted in velo-cardio-facial syndrome/DiGeorge syndrome have middle and inner ear defects. Human Molecular Genetics, 10, 2549-2556.
6. Gełernter, J., Bonvicini, K., Page, G., et al (2001) Linkage genome scan for loci predisposing to panic disorder or agoraphobia. American Journal of Medical Genetics, 105, 548-557.
7. Gratacos, M., Nadal, M., Martin-Santos, R., et al (2001) A polymorphic genomic duplication on human chromosome 15 is a susceptibility factor for panic and phobic disorders. Cell, 106, 367-379.
8. Ji, Y., Eichler, E. E., Schwartz, S., et al (2000a) Structure of chromosomal duplicons and their role in mediating human genomic disorders. Genome Research, 10, 597-610.
9. _, Rebert, N. A., Joslin, J. M., et al (2000b) Structure of the highly conserved HERC2 gene and of multiple partially duplicated paralogs in human. Genome Research, 10, 319-329.
10. Lelliott, P., Marks, I., McNamee, G., et al (1989) Onset of panic disorder with agoraphobia. Toward an integrated model. Archives of General Psychiatry, 46, 1000-1004.
11. Lupski, J. R. (1998) Genomic disorders: Structural features of the genome can lead to DNA rearrangements and human disease traits. Trends in Genetics, 14, 417-422.
12. Marks, I. M. (1986) Genetics of fear and anxiety disorders. British Journal of Psychiatry, 149, 406-418.
13. Martin-Santos, R., Bulbena, A., Porta, M., et al (1998) Association between joint hypermobility syndrome and panic disorder. American Journal of Psychiatry, 155, 1578-1583.
14. Riley, B. P. & McGuffin, P. (2000) Linkage and associated studies of schizophrenia. American Journal of Medical Genetics (Neuropsychiatric Genetics), 97, 23-44.
15. Shaikh, T. H., Kurahashi, H., Saitta, S.C., et al (2000) Chromosome 22-specific low copy repeats and the 22q11.2 deletion syndrome: Genomic organization and deletion endpoint analysis. Human Molecular Genetics, 9, 489-501.
16. Shprintzen, R. J. (2000) Velo-cardio-facial syndrome: a distinctive behavioral phenotype. Mental Retardation and Developmental Disabilities Research Reviews, 6, 142-147.
17. Stankiewicz, P. & Lupski, J. R. (2002) Genome architecture, rearrangements and genomic disorders. Trends in Genetics, 18, 74-82.
18. Thornton, J. W. & DeSalle, R. (2000) Gene family evolution and homology: Genomics meets phylogenetics. Annual Review of Genomics and Human Genetics, 1, 41-73.