Dynamics of abducens nucleus neuron discharges during disjunctive saccades

Journal of Neurophysiology

Volumn 88, Issue 6, 2002, Pages 3452-3468

  Sylvestre, Pierre A ^a   Cullen, Kathleen E ^a,b  

^a MCGILL UNIVERSITY   (Canada)

^b NONE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ABDUCENS NUCLEUS; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; EYE FIXATION; MACACA; NERVE CELL; NERVE PROJECTION; NONHUMAN; PRIORITY JOURNAL; SACCADIC EYE MOVEMENT; VISION; VISUAL FIELD; VISUAL SYSTEM;

EID: 0036898612     PISSN: 00223077     EISSN: None     Source Type: Journal    
DOI: 10.1152/jn.00331.2002     Document Type: Article

References (63)

1. Broussard DA, DeCharms RC, and Lisberger SG. Inputs from the ipsilateral and contralateral vestibular apparatus to behaviorally characterized abducens neurons in rhesus monkey. J Neurophysiol 74: 2445-2459, 1995.
2. Büttner-Ennever JA, Horn AKE, Scherberger H, and D'Ascanio P. Motoneurons of twitch and nontwitch extraocular muscle fibers in the abducens, trochlear, and oculomotor nuclei of monkeys. J Comp Neurol 438: 318-335, 2001.
3. Büttner-Ennever JA, Horn AKE, Graf W, and Ugolini G. Modern concepts of brainstem anatomy. From extraocular motoneurons to proprioceptive pathways. Ann NY Acad Sci 956: 75-84, 2002.
4. Carpenter J and Bithell J. Bootstrap confidence intervals: when, which, what? A practical guide for medical statisticians. Stat Med 19: 1141-1164, 2000.
5. Chaturvedi V and Van Gisbergen JAM. Perturbation of combined saccadevergence movements by microstimulation in monkey superior colliculus. J Neurophysiol 81: 2279-2296, 1999.
6. Chaturvedi V and Van Gisbergen JAM. Stimulation in the rostral pole of monkey superior colliculus: Effects on vergence eye movements. Exp Brain Res 132: 72-78, 2000.
7. Collewijn H, Erkelens CJ, and Steinman RM. Voluntary binocular gaze-shifts in the plane of regard: Dynamics of version and vergence. Vision Res 35: 3335-3358, 1995.
8. Collewijn H, Erkelens CJ, and Steinman RM. Trajectories of the human binocular fixation point during conjugate and non-conjugate gaze-shifts. Vision Res 37: 1049-1069, 1997.
9. Cullen KE, Galiana HL, and Sylvestre PA. Comparing extraocular motoneuron discharges during head-restrained saccades and head-unrestrained gaze shifts. J Neurophysiol 83: 630-637, 2001.
10. Cullen KE and Guitton D. Analysis of primate IBN spike trains using system identification techniques. I. Relationship to eye movement dynamics during head-fixed saccades. J Neurophysiol 78: 3259-3282, 1997a.
11. Cullen KE and Guitton D. Analysis of primate IBN spike trains using system identification techniques. II. Relationship to gaze, eye, and head movement dynamics during head-free gaze shifts. J Neurophysiol 78: 3283-3306, 1997b.
12. Cullen KE, Rey CD, Guitton D, and Galiana HL. The use of system identification techniques in the analysis of oculomotor burst neuron spike train dynamics. J Comput Neurosci 3: 347-368, 1996.
13. Delgado-Garcia JM, Del Pozo F, and Baker R. Behavior of neurons in the abducens nucleus of the alert cat. I. Motoneurons. Neuroscience 17: 929-952, 1986a.
14. Delgado-Garcia JM, Del Pozo F, and Baker R. Behavior of neurons in the abducens nucleus of the alert cat. II. Internuclear neurons. Neuroscience 17: 953-973, 1986b.
15. Destombes J, Gogan P, and Rouvière A. The fine structure of neurons and cellular relationships in the abducens nucleus in the cat. Exp Brain Res 35: 249-267, 1979.
16. Enright JT. Changes in vergence mediated by saccades. J Physiol (Lond) 350: 9-31, 1984.
17. Erkelens CJ, Steinman RM, and Collewijn H. Ocular vergence under natural conditions. II. Gaze shifts between real targets differing in distance and direction. Proc R Soc Lond 236: 441-465, 1989.
18. Fuchs AF and Luschei ES. Firing patterns of abducens neurons of alert monkeys in relationship to horizontal eye movement. J Neurophysiol 33: 382-392, 1970.
19. Fuchs AF and Robinson DA. A method for measuring horizontal and vertical eye movements in the monkey. J Physiol (Lond) 191: 609-631, 1966.
20. Fuchs AF, Scudder CA, and Kaneko CRS. Discharge patterns and recruitment order of identified motoneurons and internuclear neurons in the monkey abducens nucleus. J Neurophysiol 60: 1874-1895, 1988.
21. Gamlin PDR. Subcortical neural circuits for ocular accommodation and vergence in primates. Ophthal Physiol Opt 19: 81-89, 1999.
22. Gamlin PDR, Gnadt JW, and Mays LE. Abducens internuclear neurons carry an inappropriate signal for ocular convergence. J Neurophysiol 62: 70-81, 1989.
23. Gamlin PDR and Mays LE. Dynamic properties of medial rectus motoneurons during vergence eye movements. J Neurophysiol 67: 64-74, 1992.
24. Hayes AV, Richmond BJ, and Optican LM. A UNIX-based multiple process system for real-time data acquisition and control. WESCON Conf Proc 2: 1-10, 1982.
25. Helmholtz JA. Treatise on Physiological Optics. New York: Dover, 1910.
26. Hering E. Lehre Vom Binokularen Sehen, edited by Bridgeman B and Stark L. New York: Plenum Press, 1977.
27. Judge SJ and Cumming BG. Neurons in monkey midbrain with activity related to vergence eye movement and accommodation. J Neurophysiol 55: 915-930, 1986.
28. Judge SJ, Richmond BJ, and Chu FC. Implantation of magnetic search coils for measurement of eye position: An improved method. Vision Res 20: 535-538, 1980.
29. Keller EL. Accommodative vergence in the alert monkey. Motor unit analysis. Vision Res 13: 1565-1575, 1973.
30. Keller EL and Robinson DA. Abducens unit behavior in the monkey during vergence movements. Vision Res 12: 369-382, 1972.
31. Kenyon RV, Ciuffreda KJ, and Stark L. Unequal saccades during vergence. Am J Opt Physiol Opt 57: 586-594, 1980.
32. King WM and Zhou W. New ideas about binocular coordination of eye movements: Is there a chameleon in the primate family tree? New Anat 261: 153-161, 2000.
33. King WM, Zhou W, Tomlinson RD, McConville KM, Page WK, Paige GD, and Maxwell JS. Eye position signals in the abducens and oculomotor nuclei of monkeys during ocular convergence. J Vestib Res 4: 401-408, 1994.
34. Maxwell JS and King WM. Dynamics and efficacy of saccade-facilitated vergence eye movements in monkeys. J Neurophysiol 68: 1248-1260, 1992.
35. Mays LE. Neural control of vergence eye movements: Convergence and divergence neurons in midbrain. J Neurophysiol 51: 1091-1108, 1984.
36. Mays LE. Has Hering been hooked? Nature Med 4: 889-890, 1998.
37. Mays LE and Gamlin PDR. Neuronal circuitry controlling the near response. Curr Opin Neurobiol 5: 763-768, 1995a.
38. Mays LE and Gamlin PDR. A neural mechanism subserving saccade-vergence interactions. In: Eye Movement Research: Mechanisms, Processes and Applications, edited by Findlay J, Walker R, and Kentridge RW. Amsterdam: Elsevier, 1995b: p.215-223.
39. Mays LE and Porter JD. Neural control of vergence eye movements: Activity of abducens and oculomotor neurons. J Neurophysiol 52: 743-761, 1984.
40. Mays LE, Porter JD, Gamlin PDR, and Tello CA. Neural control of vergence eye movements: Neurons encoding vergence velocity. J Neurophysiol 56: 1007-1021, 1986.
41. McConville K, Tomlinson RD, King WM, Paige G, and Na E-Q. Eye position signals in the vestibular nuclei: Consequences for models of integrator function. J Vest Res 4: 391-400, 1994.
42. McCrea RA, Strassman A, and Highstein SM. Morphology and physiology of abducens motoneurons and internuclear neurons intracellularly injected with horseradish peroxidase in alert squirrel monkeys. J Comp Neurol 243: 291-308, 1986.
43. Moschovakis AK, Scudder CA, and Highstein SM. The microscopic anatomy and physiology of the mammalian saccadic system. Prog Neurobiol 50: 133-254, 1996.
44. Ono H, Nakamizo S, and Steinbach MJ. Nonadditivity of vergence and saccadic eye movement. Vision Res 18: 735-739, 1978.
45. Oohira A. Vergence eye movements facilitated by saccades. Jpn J Ophtalmol 37: 400-413, 1993.
46. Press WH, Teukolsky SA, Vetterling WT, and Flannery BP. Numerical Recipes in C. The Art of Scientific Computing (2nd Ed.). New York: Cambridge, 1997, p. 689-693.
47. Ramat S, Das VE, Somers T, and Leigh RJ. Tests of two hypotheses to account for different-sized saccades during disjunctive gaze shifts. Exp Brain Res 129: 500-510, 1999.
48. Richmond BJ, Optican LM, Podell M, and Spitzer H. Temporal encoding of two-dimensional patterns by single units in primate inferior temporal cortex. I. Response characteristics. J Neurophysiol 57: 132-146, 1987.
49. Robinson DA. The mechanics of human saccadic eye movement. J Physiol (Lond) 174: 245-264, 1964.
50. Robinson DA. Oculomotor unit behavior in the monkey. J Neurophysiol 33: 393-404, 1970.
51. Schiller PH. The discharge characteristics of single units in the oculomotor and abducens nuclei of the unanesthetized monkey. Exp Brain Res 10: 347-362, 1970.
52. Scudder CA, Kaneko CRS, and Fuchs AF. The brainstem burst generator for saccadic eye movements. A modern synthesis. Exp Brain Res 142: 439-462, 2002.
53. Sokal RR and Rohlf FJ. Biometry. The Principles and Practice of Statistics in Biological Research (3rd Ed.). New York: W.H. Freeman and Co., 1995, p. 820-825.
54. Spencer RF and Sterling P. An electron microscopy study of motoneurones and interneurones in the cat abducens nucleus identified by retrograde intraaxonal transport of horseradish peroxidase. J Comp Neurol 176: 65-86, 1977.
55. Steiger H-J and Büttner-Ennever JA. Relationship between motoneurons and internuclear neurons in the abducens nucleus: A double retrograde tracer study in the cat. Brain Res 148: 181-188, 1978.
56. Sylvestre PA and Cullen KE. Quantitative analysis of abducens neuron discharge dynamics during saccadic and slow eye movements. J Neurophysiol 82: 2612-2632, 1999a.
57. Sylvestre PA and Cullen KE. Monocularly tuned discharge dynamics of abducens and brainstem inhibitor burst neurons during disjunctive saccades. Soc Neurosci Abstr 25: 1652, 1999b.
58. Sylvestre PA, Galiana HL, and Cullen KE. Conjugate and vergence oscillations during saccades and gaze shifts: Implications for integrated control of binocular motion. J Neurophysiol 87: 257-272, 2002.
59. Zee DS, Fitzgibbon EJ, and Optican LM. Saccade-vergence interactions in humans. J Neurophysiol 68: 1624-1641, 1992.
60. Zhang Y, Gamlin PDR, and Mays LE. Antidromic identification of midbrain near response cells projecting to the oculomotor nucleus. Exp Brain Res 84: 525-528, 1991.
61. Zhang Y, Mays LE, and Gamlin PDR. Characteristics of near response cells projecting to the oculomotor nucleus. J Neurophysiol 67: 944-960, 1992.
62. Zhou W and King WM. Ocular selectivity of units in oculomotor pathways. Ann NY Acad Sci 781: 724-728, 1996.
63. Zhou W and King WM. Premotor commands encode monocular eye movements. Nature 393: 692-695, 1998.