Prolongation of hippocampal miniature inhibitory postsynaptic currents in mice lacking the GABAA receptor α1 subunit

Journal of Neurophysiology

Volumn 88, Issue 6, 2002, Pages 3208-3217

  Goldstein, Peter A ^a   Elsen, Frank P ^a   Ying, Shui Wang ^a   Ferguson, Carolyn ^b   Homanics, Gregg E ^b   Harrison, Neil L ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR ALPHA1; BENZODIAZEPINE; UNCLASSIFIED DRUG; ZOLPIDEM;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG RECEPTOR BINDING; HIPPOCAMPUS; INTERNEURON; KNOCKOUT MOUSE; MOUSE; NONHUMAN; POSTSYNAPTIC INHIBITION; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; SYNAPSE;

EID: 0036898569     PISSN: 00223077     EISSN: None     Source Type: Journal    
DOI: 10.1152/jn.00885.2001     Document Type: Article

References (55)

1. Banks MI and Pearce RA. Kinetic differences between synaptic and extrasynaptic receptors in CA1 pyramidal cells. J Neurosci 20: 937-948, 2000.
2. A.slow. J Neurosci 18: 1305-1317, 1998.
3. A receptors: Classification on the basis of subunit structure and receptor function. Pharmacol Rev 50: 291-313, 1998.
4. A receptors suggest differential targeting of receptor subtypes. J Neurosci 19: 2960-2973, 1999.
5. Brünig I, Scotti E, Sidler C, and Fritschy JM. Intact sorting, targeting, and clustering of γ-aminobutyric acid A receptor subtypes in hippocampal neurons in vitro. J Comp Neurol 443: 43-55, 2002.
6. A receptor. J Neurosci 16: 5415-5424, 1996.
7. A receptor. J Neurosci 22: 5572-5580, 2002.
8. A receptor channels. J Neurophysiol 71: 1318-1335, 1994.
9. Ebert B, Wafford KA, Whiting PJ, Krogsgaard-Larsen P, and Kemp JA. Molecular pharmacology of γ-aminobutyric acid type A receptor agonists and partial agonists in oocytes injected with different α, β, and γ receptor subunit combinations. Mol Pharmacol 46: 957-963, 1994.
10. Franks NP and Lieb WR. Inhibitory synapses: Anaesthetics set their sites on ion channels. Nature 389: 334-335, 1997.
11. A-receptor heterogeneity in the adult rat brain: Differential regional and cellular distribution of seven major subunits. J Comp Neurol 359: 154-194, 1995.
12. A receptors containing the α1 subunit to neurochemically distinct subpopulations of rat hippocampal interneurons. Eur J Neurosci 6: 837-853, 1994.
13. A receptor gating kinetics on the α-subunit isoform: Implications for structure-function relations and synaptic transmission. J Physiol (Lond) 489: 529-543, 1995.
14. A receptors. Mol Pharmacol 43: 970-975, 1993.
15. A receptor occupancy. Eur J Neurosci 12: 810-818, 2000.
16. rd Ed.) Sunderland, MA: Sinauer Associates, 2001, p. 445-449.
17. Huntsman MM, Porcello DM, Homanics GE, Delorey TM, and Huguenard JR. Reciprocal inhibitory connections and network synchrony in the mammalian thalamus. Science 283: 541-543, 1999.
18. Jones MV and Harrison NL. Effects of volatile anesthetics on the kinetics of inhibitory postsynaptic currents in cultured rat hippocampal neurons. J Neurophysiol 70: 1339-1349, 1993.
19. A receptors in the hippocampus. J Neurosci 22: 2513-2521, 2002.
20. A receptor modulation by propofol. Neuropharmacology 36: 941-949, 1997.
21. A receptor subunit mRNAs in the rat brain. III. Embryonic and postnatal development. J Neurosci 12: 4151-4172, 1992.
22. A receptor channels are dependent on α-subunit isoform. Biophys J 73: 2518-2526, 1997.
23. A receptor heterogeneity. Nature 335: 76-79, 1988.
24. Madison DV and Nicoll RA. Control of the repetitive discharge of rat CA 1 pyramidal neurones in vitro. J Physiol (Lond) 354: 319-331, 1984.
25. McCormick DA. Neurotransmitter actions in the thalamus and cerebral cortex. J Clin Neurophysiol 9: 212-223, 1992.
26. A receptor α1 subtype. Nat Neurosci 36: 587-592, 2000.
27. A-receptor subtypes really occur in the brain? Trends Neurosci 19: 139-143, 1996.
28. A and glycine receptors. Nature 389: 385-389, 1997.
29. Nagy A, Cocza E, Merenties Diaz E, Prideaux VR, Ivanyi E, Markkula M, and Rossant J. Embryonic stem cells alone are able to support fetal development in the mouse. Development 110: 815-821, 1990.
30. A receptor number underlie variation in GABA mini amplitude. Neuron 19: 697-709, 1997.
31. Nusser Z, Sieghart W, Benke D, Fritschy JM, and Somogyi P. Differential synaptic localization of two major γ-aminobutyric acid type A receptor a subunits on hippocampal pyramidal cells. Proc Natl Acad Sci USA 93: 11939-11944, 1996.
32. A receptor α subunits expression with the properties of IPSCs in the developing thalamus. J Neurosci 20: 2202-2208, 2000.
33. A receptors. Toxicol Lett 100-101: 193-201, 1998.
34. 2+: Dual recordings in slices of adult rat hippocampus. Eur J Neurosci 11: 3552-3564, 1999.
35. A receptors in central synapses. J Neurosci 19: 578-588, 1999.
36. A receptors: Immunocytochemical distribution of 13 subunits in the adult rat brain. Neuroscience 101: 815-850, 2000.
37. A-benzodiazepine receptors produced in transfected cells. Science 245: 1389-1392, 1989.
38. A receptor α5-subunit creates novel type II benzodiazepine receptor pharmacology. J Neurochem 54: 1802-1804, 1990.
39. A receptor subtypes. Nature 401: 796-800, 1999.
40. A receptor subtypes. Pharmacol Rev 47: 181-234, 1995.
41. A receptors. Neurochem Int 34: 379-385, 1999.
42. Silver RA, Cull-Candy SG, and Takahashi T. Non-NMDA glutamate receptor occupancy and open probability at a rat cerebellar synapse with single and multiple release sites. J Physiol (Lond) 494: 231-250, 1996.
43. A receptor subunits in the rat hippocampus. 1. Immunocytochemical distribution of 13 subunits. Neuroscience 80: 987-1000, 1997.
44. A receptor subtype in the brain is not lethal in mice. J Neurosci 21: 3409-3418, 2001.
45. Thomson AM, Bannister AP, Hughes DI, and Pawelzik H. Differential sensitivity to Zolpidem of IPSPs activated by morphologically identified CA1 interneurons in slices of rat hippocampus. Eur J Neurosci 12: 425-436, 2000.
46. Thompson SM, Masukawa LM, and Prince DA. Temperature dependence of intrinsic membrane properties and synaptic potentials in hippocampal CA1 neurons in vitro. J Neurosci 5: 817-824, 1985.
47. A receptors. Neuropharmacology 35: 1375-1382, 1996.
48. Traynelis SE, Silver RA, and Cull-Candy SG. Estimated conductance of glutamate receptor channels activated during EPSCs at the cerebellar mossy fiber-granule cell synapse. Neuron 11: 279-289, 1993.
49. A receptor subtype. J Neurosci 17: 2728-2737, 1997.
50. Verdoorn TA. Formation of heteromeric γ-aminobutyric acid type A receptors containing two different α subunits. Mol Pharmacol 45: 475-480, 1994.
51. A receptor α1 subunit deletion prevents developmental changes of inhibitory synaptic currents in cerebellar neurons. J Neurosci 21: 3009-3016, 2001.
52. A receptor subtypes. Mol Pharmacol 43: 240-244, 1993.
53. A receptor α4-subunit. FEBS Lett 289: 227-230, 1991.
54. A receptor subunit mRNAs in the rat brain. I. Telencephalon, diencephalon, mesencephalon. J Neurosci 12: 1040-1062, 1992.
55. Yoshimura Y, Kimura F, and Tsumoto T. Estimation of single channel conductance underlying synaptic transmission between pyramidal cells in the visual cortex. Neuroscience 88: 347-352, 1999.