Hemoglobin Wayne in a British family: Identification by electrospray ionization/mass spectrometry

Clinical Chemistry

Volumn 48, Issue 12, 2002, Pages 2261-2263

  Reynolds, Tim M ^a,b   Harvey, Tim C ^c   Green, Brian N ^d   Smith, Adrian ^a   Hartland, Andrew J ^e  

^a QUEEN S HOSPITAL   (United Kingdom)

^b UNIVERSITY OF WOLVERHAMPTON   (United Kingdom)

^c MANOR HOSPITAL   (United Kingdom)

^d MICROMASS UK LTD   (United Kingdom)

^e NORTHWICK PARK HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON MONOXIDE; HEMOGLOBIN; HEMOGLOBIN WAYNE; UNCLASSIFIED DRUG;

ADULT; ANALYTIC METHOD; ARTICLE; BOHR EFFECT; CASE REPORT; DIAGNOSTIC VALUE; FEMALE; FRAMESHIFT MUTATION; HEMOGLOBIN DETERMINATION; HUMAN; MASS SPECTROMETRY; NEWBORN; OXYGEN AFFINITY; TANDEM MASS SPECTROMETRY; TECHNIQUE; UNITED KINGDOM;

EID: 0036892823     PISSN: 00099147     EISSN: None     Source Type: Journal    
DOI: 10.1093/clinchem/48.12.2261     Document Type: Article

References (8)

1. Seid-Akhavan M; Winter WP, Abramson RK, Rucknagel DL. Hemoglobin Wayne: A frameshift mutation detected in human hemoglobin α chains. Proc Natl Acad Sci U S A 1976;73:882-6.
2. Huisman TH, Headlee MG, Wilson JB, Lam H, Johnson SE, Webber BB. Hb Wayne, the frameshift variant with extended α chains observed in a Caucasian family from Michigan. Hemoglobin 1984;8:1-15.
3. Salkie ML, Higgins T, Morrison DM, Wilson JB, Gu LH, Curuk MA, et al. A Canadian family with Hb Wayne; characterization by HPLC and DNA sequencing. Hemoglobin 1992;16:515-9.
4. Moo-Penn WF, Jue DL, Johnson MH. Structural and functional studies of haemoglobin Wayne: an elongated α-chain variant. J Mol Biol 1984;180: 1119-40.
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7. 1c in diabetes mellitus: Structure, function, DNA sequence. Mayo Clinic Proc 1998;73:321-8.
8. Reynolds TM, McMillan F, Smith A, Hutchinson A, Green B. Haemoglobin Le Lamentin (α20 (B1) His→Gln) in a British family: Identification by electrospray mass spectrometry. J Clin Pathol 1998;51:467-70.