Autonomic control after blockade of the norepinephrine transporter: A model of orthostatic intolerance

Journal of Applied Physiology

Volumn 93, Issue 6, 2002, Pages 2192-2198

  Carson, Robert P ^a   Diedrich, André ^a   Robertson, David ^a,b  

^a VANDERBILT UNIVERSITY   (United States)

^b Autonomic Dysfunction Center   (United States)

Author keywords

Baroreflex; Dysautonomia; Net; Postural orthostatic tachycardia syndrome

Indexed keywords

3,4 DIHYDROXYPHENYLETHYLENE GLYCOL; CATECHOLAMINE; DESIPRAMINE; META TYRAMINE; NITROPRUSSIDE SODIUM; NORADRENALIN; NORADRENALIN TRANSPORTER; 4 HYDROXY 3 METHOXYPHENYLETHYLENE GLYCOL; ADRENERGIC RECEPTOR AFFECTING AGENT; COTRANSPORTER; DRUG DERIVATIVE; SLC6A2 PROTEIN, RAT;

ADOLESCENT; ARTICLE; AUTONOMIC NERVOUS SYSTEM; BRAIN STEM; CARDIOVASCULAR AUTOREGULATION; CATECHOLAMINE BLOOD LEVEL; CONTROLLED STUDY; FEMALE; NONHUMAN; ORTHOSTATIC HYPOTENSION; PHARMACOLOGICAL BLOCKING; PRESSORECEPTOR REFLEX; PRIORITY JOURNAL; RAT; SPECTROSCOPY; SYMPATHETIC BLOCKING; TACHYCARDIA; ADRENERGIC SYSTEM; ANIMAL; BLOOD; BLOOD PRESSURE; BODY WEIGHT; DRUG ANTAGONISM; DRUG EFFECT; HEART RATE; NON-PROGRAMMATIC; PATHOPHYSIOLOGY; PHYSIOLOGY; SHY DRAGER SYNDROME; SPRAGUE DAWLEY RAT;

NON-PROGRAMMATIC;

ADRENERGIC UPTAKE INHIBITORS; ANIMALS; BAROREFLEX; BLOOD PRESSURE; BODY WEIGHT; DESIPRAMINE; FEMALE; HEART RATE; METHOXYHYDROXYPHENYLGLYCOL; NOREPINEPHRINE; NOREPINEPHRINE PLASMA MEMBRANE TRANSPORT PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; SHY-DRAGER SYNDROME; SYMPATHETIC NERVOUS SYSTEM; SYMPORTERS; TACHYCARDIA;

EID: 0036892640     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/japplphysiol.00033.2002     Document Type: Article

References (33)

1. Bertram D, Barres C, and Julien C. Effect of desipramine on spontaneous arterial pressure oscillations in the rat. Eur J Pharmacol 378: 265-271, 1999.
2. Blanc J, Grichois M, and Elghozi J. Effects of clonidine on blood pressure and heart rate responses to an emotional stress in the rat: a spectral study. Clin Exp Pharmacol Physiol 18: 711- 717, 1991.
3. Bohn LM, Xu F, Gainetdinov RR, and Caron MG. Potentiated opioid analgesia in norepinephrine transporter knock-out mice. J Neurosci 20: 9040-9045, 2000.
4. Brown DR, Brown LV, Patwardhan A, and Randall DC. Sympathetic activity and blood pressure are tightly coupled at 0.4 Hz in conscious rats. Am J Physiol Regul Integr Comp Physiol 267: R1378-R1384, 1994.
5. Carson RP, Appalsamy M, Diedrich A, Davis TL, and Robertson D. Animal model of neuropathic tachycardia syndrome. Hypertension 37: 1357-1361, 2001.
6. Cerutti C, Gustin MP, Paultre CZ, Lo M, Julien C, Vincent M, and Sassard J. Autonomic nervous system and cardiovascular variability in rats: A spectral analysis approach. Am J Physiol Heart Circ Physiol 261: H1292-H1299, 1991.
7. Cohen MD, Finberg J, Dibner-Dunlap M, Yuih SN, and Thames MD. Effects of desipramine hydrochloride on peripheral sympathetic nerve activity. Am J Physiol Regul Integr Comp Physiol 258: R876-R882, 1990.
8. Daffonchio A, Franzelli C, Di Rienzo M, Castiglioni P, Mancia G, and Ferrari AU. Sympathetic, parasympathetic and non-autonomic contributions to cardiovascular spectral powers in unanesthetized spontaneously hypertensive rats. J Hypertens 13: 1636-1642, 1995.
9. Denolle T, Pellizzoni C, Jannuzzo G, and Poggesi I. Hemodynamic effects of reboxetine in healthy male volunteers. Clin Pharmacol Ther 66: 282-287, 1999.
10. Eisenhofer G, Esler MD, Meredith IT, Ferrier C, Lambert G, and Wennings G. Neuronal re-uptake of noradrenaline by sympathetic nerves in humans. Clin Sci (Lond) 80: 257-263, 1991.
11. Eisenhofer G, Friberg P, Goldstein DS, and Esler M. Differential actions of desipramine on sympathoadrenal release of noradrenaline and adrenaline. Eur J Clin Pharmacol 40: 263-265, 1995.
12. Esler MD, Wallin G, Dorward PK, Eisenhofer G, Westerman R, Meredith I, Lambert G, Cox HS, and Jennings G. Effects of desipramine on sympathetic nerve firing and norepinephrine spillover to plasma in humans. Am J Physiol Regul Integr Comp Physiol 29: R817-R823, 1991.
13. 2-adrenoceptor. Pharmacol Rev 35: 143-180, 1983.
14. Grichois M, Blanc J, Deckert V, and Elghozi J. Differential effects of enalapril and hyralazine on short-term variability of blood pressure and heart rate in rats. J Cardiovasc Pharmacol 19:863-869, 1992.
15. 2-Adrenoceptor-mediated presynaptic inhibition in bulbospinal neurons of rostral ventrolateral medulla. Am J Physiol Heart Circ Physiol 277: H1069-H1080, 1999.
16. Hayes JR, Born GF, and Rosenbaum AH. Incidence of orthostatic hypotension in patients with primary effective disorders treated with tricyclic antidepressants. Mayo Clin Proc 52: 509-512, 1977.
17. Jacob G and Biaggioni I. Idiopathic orthostatic intolerance and postural tachycardia syndromes. Am J Med Sci 317: 88-101, 1999.
18. Low PA and Schondorf R. Postural tachycardia syndrome. In: Primer on the Autonomic Nervous System, edited by Robertson D, Low PA, and Polinsky RJ. San Diego, CA: Academic, 1996, p. 279-282.
19. Openheim A and Schafer R. Digital Signal Processing. Englewood Cliffs, NJ: Prentice-Hall, 1975.
20. Persson PB, Stauss HM, Chung O, Wittman U, and Unger T. Spectrum analysis of sympathetic nerve activity and blood pressure in conscious rats. Am J Physiol Heart Circ Physiol 263: H1348-H1355, 1992.
21. Robertson D. The epidemic of orthostatic tachycardia and orthostatic intolerance. Am J Med Sci 317: 75-77, 1999.
22. Robertson D, Hollister AS, Biaggioni I, Netterville JL, Mosqueda-Garcia R, and Robertson RM. The diagnosis and treatment of baroreflex failure. N Engl J Med 329: 1449-1455, 1993.
23. 2-adrenergic receptor subtypes in cells and tissues. Pharmacol Ther 84: 193-205, 1999.
24. Schroeder C, Tank J, Boschmann M, Diedrich A, Sharma AM, Biaggioni I, Luft RC, and Jordan J. Selective norepinephrine reuptake inhibition as a human model of orthostatic intolerance. Circulation 105: 347-353, 2002.
25. Shannon JR, Flattem NL, Jordan J, Jacob G, Black BK, Biaggioni I, Blakely RD, and Robertson D. Orthostatic intolerance and tachycardia associated with norepinephrine-transporter deficiency. N Engl J Med 342: 541-549, 2000.
26. Shannon JR, Jordan J, Black BK, Costa F, and Robertson D. Uncoupling of the baroreflex by NN-cholinergic blockade in dissecting the components of cardiovascular regulation. Hypertension 32: 101-107, 1998.
27. Stauss HM, Mrowka R, Nafz B, Patzak A, Unger T, and Persson PB. Does low frequency power of arterial blood pressure reflect sympathetic tone? J Auton Nerv Syst 54: 145-154, 1995.
28. Tatsumi M, Groshan K, Blakely RD, and Richelson E. Pharmacological profile of anitdepressants and related compounds at human monoamine transporters. Eur J Pharmacol 340:249-258, 1997.
29. Tsai ML, Shaw FZ, and Yen CT. Quantitative relationship between fluctuations of blood pressure and sympathetic nerve activity in pentobarbital anesthetized rats. Neurosci Lett 263: 85-88, 1999.
30. Tung CS, Goldberg MR, Hollister AS, and Robertson D. Central and peripheral cardiovascular effects of α-methylepinephrine. J Pharmacol Exp Ther 227: 484-489, 1983.
31. Tung CS, Goldberg MR, Hollister AS, and Robertson D. Both α- and β-adrenoceptors contribute to the central depressor effect of catecholamines. Brain Res 456: 64-70, 1988.
32. Walsh BT, Hadigan CM, and Wong LM. Increased pulse and blood pressure associated with desipramine treatment of bulimia nervosa. J Clin Psychopharmacol 12: 163-168, 1992.
33. Xu F, Gainetdinov RR, Wetsel WC, Jones SR, Bohn LM, Miller GW, Wang Y, and Caron MG. Mice lacking the norepinephrine transporter are supersensitive to psychostimulants. Nat Neurosci 3: 465-471, 2000.